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Gender-specific association between urinary sodium excretion and body composition: Analysis of the 2008-2010 Korean National Health and Nutrition Examination Surveys.
Metabolism. 2015 Jul; 64(7):837-44.M

Abstract

OBJECTIVE

Few studies have reported the relationship between sarcopenia and the estimated amount of sodium excreted in 24 h, as measured by the spot urine test (E24UNA), in a community-dwelling cohort. We investigated the gender specific association between E24UNA values and body composition indices.

MATERIALS AND METHODS

Data from a total of 7162 participants (3545 men and 3617 postmenopausal women) aged 45 years or older were obtained from multiple Korea National Health and Nutrition Examination Surveys (2008-2010) and analyzed. The total amount of sodium excreted in the urine in a 24-h period was estimated with spot urine specimens. Sarcopenia was defined as an appendicular skeletal muscle mass divided by body weight (ASM/Wt) that was less than 1 standard deviation below the sex-specific mean for young adults.

RESULTS

E24UNA values were positively correlated with body mass index, waist circumference, total fat mass, and blood pressure; in contrast, E24UNA values were negatively correlated with ASM/Wt in both sexes. Compared with those in the lowest E24UNA tertile, participants in the highest E24UNA tertile were at higher risk for sarcopenia (men: odds ratio (OR)=1.3 [95% confidence interval (CI)=1.07-1.59]; women: OR=1.41 [95% CI=1.16-1.73]). Further classification of subjects with sarcopenia into sarcopenic obese and sarcopenic nonobese groups revealed that the highest E24UNA values were found in the sarcopenic obese group; this difference was statistically significant. The next highest levels were found in the sarcopenic nonobese group, followed by the nonsarcopenic group. This trend was observed in both sexes.

CONCLUSION

High E24UNA values were independently associated with both sarcopenia and obesity in Korean individuals older than 45 years. These results suggest that high salt intake may have a deleterious effect on body composition.

Authors+Show Affiliations

Department of Internal Medicine, Yonsei University, Wonju College of Medicine, Republic of Korea.Department of Internal Medicine, Yonsei University, Wonju College of Medicine, Republic of Korea.Department of Internal Medicine, Yonsei University, Wonju College of Medicine, Republic of Korea. Electronic address: domoe46@yonsei.ac.kr.Department of Internal Medicine, Yonsei University, Wonju College of Medicine, Republic of Korea.Department of Internal Medicine, Yonsei University, Wonju College of Medicine, Republic of Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25873364

Citation

Huh, Ji Hye, et al. "Gender-specific Association Between Urinary Sodium Excretion and Body Composition: Analysis of the 2008-2010 Korean National Health and Nutrition Examination Surveys." Metabolism: Clinical and Experimental, vol. 64, no. 7, 2015, pp. 837-44.
Huh JH, Lim JS, Lee MY, et al. Gender-specific association between urinary sodium excretion and body composition: Analysis of the 2008-2010 Korean National Health and Nutrition Examination Surveys. Metab Clin Exp. 2015;64(7):837-44.
Huh, J. H., Lim, J. S., Lee, M. Y., Chung, C. H., & Shin, J. Y. (2015). Gender-specific association between urinary sodium excretion and body composition: Analysis of the 2008-2010 Korean National Health and Nutrition Examination Surveys. Metabolism: Clinical and Experimental, 64(7), 837-44. https://doi.org/10.1016/j.metabol.2015.03.010
Huh JH, et al. Gender-specific Association Between Urinary Sodium Excretion and Body Composition: Analysis of the 2008-2010 Korean National Health and Nutrition Examination Surveys. Metab Clin Exp. 2015;64(7):837-44. PubMed PMID: 25873364.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gender-specific association between urinary sodium excretion and body composition: Analysis of the 2008-2010 Korean National Health and Nutrition Examination Surveys. AU - Huh,Ji Hye, AU - Lim,Jung Soo, AU - Lee,Mi Young, AU - Chung,Choon Hee, AU - Shin,Jang Yel, Y1 - 2015/04/01/ PY - 2015/01/12/received PY - 2015/03/02/revised PY - 2015/03/25/accepted PY - 2015/4/16/entrez PY - 2015/4/16/pubmed PY - 2015/8/8/medline KW - 24-hr urine sodium KW - Gender specificity KW - Metabolic syndrome KW - Obesity KW - Sarcopenia SP - 837 EP - 44 JF - Metabolism: clinical and experimental JO - Metab. Clin. Exp. VL - 64 IS - 7 N2 - OBJECTIVE: Few studies have reported the relationship between sarcopenia and the estimated amount of sodium excreted in 24 h, as measured by the spot urine test (E24UNA), in a community-dwelling cohort. We investigated the gender specific association between E24UNA values and body composition indices. MATERIALS AND METHODS: Data from a total of 7162 participants (3545 men and 3617 postmenopausal women) aged 45 years or older were obtained from multiple Korea National Health and Nutrition Examination Surveys (2008-2010) and analyzed. The total amount of sodium excreted in the urine in a 24-h period was estimated with spot urine specimens. Sarcopenia was defined as an appendicular skeletal muscle mass divided by body weight (ASM/Wt) that was less than 1 standard deviation below the sex-specific mean for young adults. RESULTS: E24UNA values were positively correlated with body mass index, waist circumference, total fat mass, and blood pressure; in contrast, E24UNA values were negatively correlated with ASM/Wt in both sexes. Compared with those in the lowest E24UNA tertile, participants in the highest E24UNA tertile were at higher risk for sarcopenia (men: odds ratio (OR)=1.3 [95% confidence interval (CI)=1.07-1.59]; women: OR=1.41 [95% CI=1.16-1.73]). Further classification of subjects with sarcopenia into sarcopenic obese and sarcopenic nonobese groups revealed that the highest E24UNA values were found in the sarcopenic obese group; this difference was statistically significant. The next highest levels were found in the sarcopenic nonobese group, followed by the nonsarcopenic group. This trend was observed in both sexes. CONCLUSION: High E24UNA values were independently associated with both sarcopenia and obesity in Korean individuals older than 45 years. These results suggest that high salt intake may have a deleterious effect on body composition. SN - 1532-8600 UR - https://www.unboundmedicine.com/medline/citation/25873364/Gender_specific_association_between_urinary_sodium_excretion_and_body_composition:_Analysis_of_the_2008_2010_Korean_National_Health_and_Nutrition_Examination_Surveys_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(15)00088-8 DB - PRIME DP - Unbound Medicine ER -