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Nutritional vitamin D supplementation and health-related outcomes in hemodialysis patients: a protocol for a systematic review and meta-analysis.
Syst Rev 2015; 4:13SR

Abstract

BACKGROUND

The prevalence of vitamin D deficiency in hemodialysis patients is high. While most hemodialysis patients are treated with activated vitamin D (1,25[OH]2D) to prevent renal osteodystrophy, clinical practices of the screening and treatment of 25(OH)2D deficiency are highly variable. It is unclear if nutritional vitamin D supplementation with D2 or D3 provides an additional clinical benefit beyond that provided by activated vitamin D treatment in this population.

METHODS/DESIGN

We will conduct a systematic review of nutritional vitamin D (D2/D3) supplementation and health-related outcomes in hemodialysis patients according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The primary objective is to assess the impact of nutritional vitamin D supplementation on clinical outcomes relevant in hemodialysis patients, such as mortality, cardiovascular events, infections, and fractures. Secondary outcomes will include anemia, hyperparathyroidism, medication use (erythrocyte-stimulating agents, activated vitamin D), and quality of life. We will search MEDLINE, Scopus, Web of Science, and ClinicalTrials.gov for randomized, controlled trials of nutritional vitamin D supplementation (ergocalciferol/D2 or cholecalciferol/D3) in chronic hemodialysis patients. The Cochrane Risk Assessment Tool will be used to assess the quality of eligible studies. We will perform meta-analyses using standard techniques for the outcomes listed above if pooling is deemed appropriate/sufficient. The results of this systematic review may highlight gaps in our knowledge of the relevance of nutritional vitamin D in end-stage renal disease, allowing for the informed design of clinical trials assessing the impact of nutritional vitamin D therapy in the hemodialysis population in the future.

SYSTEMATIC REVIEW REGISTRATION

PROSPERO CRD42014013931.

Authors+Show Affiliations

Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1243, New York, NY, 10029, USA. Anita.Mehrotra@mssm.edu.Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1243, New York, NY, 10029, USA. WaiYin.Leung@mountsinai.org.Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1243, New York, NY, 10029, USA. Tannia.Joson@mssm.edu.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

25874904

Citation

Mehrotra, Anita, et al. "Nutritional Vitamin D Supplementation and Health-related Outcomes in Hemodialysis Patients: a Protocol for a Systematic Review and Meta-analysis." Systematic Reviews, vol. 4, 2015, p. 13.
Mehrotra A, Leung WY, Joson T. Nutritional vitamin D supplementation and health-related outcomes in hemodialysis patients: a protocol for a systematic review and meta-analysis. Syst Rev. 2015;4:13.
Mehrotra, A., Leung, W. Y., & Joson, T. (2015). Nutritional vitamin D supplementation and health-related outcomes in hemodialysis patients: a protocol for a systematic review and meta-analysis. Systematic Reviews, 4, p. 13. doi:10.1186/s13643-015-0002-x.
Mehrotra A, Leung WY, Joson T. Nutritional Vitamin D Supplementation and Health-related Outcomes in Hemodialysis Patients: a Protocol for a Systematic Review and Meta-analysis. Syst Rev. 2015 Feb 21;4:13. PubMed PMID: 25874904.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nutritional vitamin D supplementation and health-related outcomes in hemodialysis patients: a protocol for a systematic review and meta-analysis. AU - Mehrotra,Anita, AU - Leung,Wai-Yin, AU - Joson,Tannia, Y1 - 2015/02/21/ PY - 2014/09/30/received PY - 2015/01/19/accepted PY - 2015/4/16/entrez PY - 2015/4/16/pubmed PY - 2016/4/5/medline SP - 13 EP - 13 JF - Systematic reviews JO - Syst Rev VL - 4 N2 - BACKGROUND: The prevalence of vitamin D deficiency in hemodialysis patients is high. While most hemodialysis patients are treated with activated vitamin D (1,25[OH]2D) to prevent renal osteodystrophy, clinical practices of the screening and treatment of 25(OH)2D deficiency are highly variable. It is unclear if nutritional vitamin D supplementation with D2 or D3 provides an additional clinical benefit beyond that provided by activated vitamin D treatment in this population. METHODS/DESIGN: We will conduct a systematic review of nutritional vitamin D (D2/D3) supplementation and health-related outcomes in hemodialysis patients according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The primary objective is to assess the impact of nutritional vitamin D supplementation on clinical outcomes relevant in hemodialysis patients, such as mortality, cardiovascular events, infections, and fractures. Secondary outcomes will include anemia, hyperparathyroidism, medication use (erythrocyte-stimulating agents, activated vitamin D), and quality of life. We will search MEDLINE, Scopus, Web of Science, and ClinicalTrials.gov for randomized, controlled trials of nutritional vitamin D supplementation (ergocalciferol/D2 or cholecalciferol/D3) in chronic hemodialysis patients. The Cochrane Risk Assessment Tool will be used to assess the quality of eligible studies. We will perform meta-analyses using standard techniques for the outcomes listed above if pooling is deemed appropriate/sufficient. The results of this systematic review may highlight gaps in our knowledge of the relevance of nutritional vitamin D in end-stage renal disease, allowing for the informed design of clinical trials assessing the impact of nutritional vitamin D therapy in the hemodialysis population in the future. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42014013931. SN - 2046-4053 UR - https://www.unboundmedicine.com/medline/citation/25874904/Nutritional_vitamin_D_supplementation_and_health_related_outcomes_in_hemodialysis_patients:_a_protocol_for_a_systematic_review_and_meta_analysis_ L2 - https://systematicreviewsjournal.biomedcentral.com/articles/10.1186/s13643-015-0002-x DB - PRIME DP - Unbound Medicine ER -