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A green algae mixture of Scenedesmus and Schroederiella attenuates obesity-linked metabolic syndrome in rats.
Nutrients 2015; 7(4):2771-87N

Abstract

This study investigated the responses to a green algae mixture of Scenedesmus dimorphus and Schroederiella apiculata (SC) containing protein (46.1% of dry algae), insoluble fibre (19.6% of dry algae), minerals (3.7% of dry algae) and omega-3 fatty acids (2.8% of dry algae) as a dietary intervention in a high carbohydrate, high fat diet-induced metabolic syndrome model in four groups of male Wistar rats. Two groups were fed with a corn starch diet containing 68% carbohydrates as polysaccharides, while the other two groups were fed a diet high in simple carbohydrates (fructose and sucrose in food, 25% fructose in drinking water, total 68%) and fats (saturated and trans fats from beef tallow, total 24%). High carbohydrate, high fat-fed rats showed visceral obesity with hypertension, insulin resistance, cardiovascular remodelling, and nonalcoholic fatty liver disease. SC supplementation (5% of food) lowered total body and abdominal fat mass, increased lean mass, and attenuated hypertension, impaired glucose and insulin tolerance, endothelial dysfunction, infiltration of inflammatory cells into heart and liver, fibrosis, increased cardiac stiffness, and nonalcoholic fatty liver disease in the high carbohydrate, high fat diet-fed rats. This study suggests that the insoluble fibre or protein in SC helps reverse diet-induced metabolic syndrome.

Authors+Show Affiliations

Centre for Systems Biology, University of Southern Queensland, Toowoomba 4350, Australia. senthil.ibt@gmail.com.MACRO-the Centre for Macroalgal Resources & Biotechnology, College of Marine and Environmental Sciences, James Cook University, Townsville 4811, Australia. marie.magnusson@jcu.edu.au.School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane 4072, Australia. l.ward@uq.edu.au.MACRO-the Centre for Macroalgal Resources & Biotechnology, College of Marine and Environmental Sciences, James Cook University, Townsville 4811, Australia. nicholas.paul@jcu.edu.au.School of Health and Wellbeing, University of Southern Queensland, Toowoomba 4350, Australia. Lindsay.Brown@usq.edu.au.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25875119

Citation

Kumar, Senthil Arun, et al. "A Green Algae Mixture of Scenedesmus and Schroederiella Attenuates Obesity-linked Metabolic Syndrome in Rats." Nutrients, vol. 7, no. 4, 2015, pp. 2771-87.
Kumar SA, Magnusson M, Ward LC, et al. A green algae mixture of Scenedesmus and Schroederiella attenuates obesity-linked metabolic syndrome in rats. Nutrients. 2015;7(4):2771-87.
Kumar, S. A., Magnusson, M., Ward, L. C., Paul, N. A., & Brown, L. (2015). A green algae mixture of Scenedesmus and Schroederiella attenuates obesity-linked metabolic syndrome in rats. Nutrients, 7(4), pp. 2771-87. doi:10.3390/nu7042771.
Kumar SA, et al. A Green Algae Mixture of Scenedesmus and Schroederiella Attenuates Obesity-linked Metabolic Syndrome in Rats. Nutrients. 2015 Apr 14;7(4):2771-87. PubMed PMID: 25875119.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A green algae mixture of Scenedesmus and Schroederiella attenuates obesity-linked metabolic syndrome in rats. AU - Kumar,Senthil Arun, AU - Magnusson,Marie, AU - Ward,Leigh C, AU - Paul,Nicholas A, AU - Brown,Lindsay, Y1 - 2015/04/14/ PY - 2014/12/17/received PY - 2015/03/18/revised PY - 2015/03/31/accepted PY - 2015/4/16/entrez PY - 2015/4/16/pubmed PY - 2016/1/31/medline SP - 2771 EP - 87 JF - Nutrients JO - Nutrients VL - 7 IS - 4 N2 - This study investigated the responses to a green algae mixture of Scenedesmus dimorphus and Schroederiella apiculata (SC) containing protein (46.1% of dry algae), insoluble fibre (19.6% of dry algae), minerals (3.7% of dry algae) and omega-3 fatty acids (2.8% of dry algae) as a dietary intervention in a high carbohydrate, high fat diet-induced metabolic syndrome model in four groups of male Wistar rats. Two groups were fed with a corn starch diet containing 68% carbohydrates as polysaccharides, while the other two groups were fed a diet high in simple carbohydrates (fructose and sucrose in food, 25% fructose in drinking water, total 68%) and fats (saturated and trans fats from beef tallow, total 24%). High carbohydrate, high fat-fed rats showed visceral obesity with hypertension, insulin resistance, cardiovascular remodelling, and nonalcoholic fatty liver disease. SC supplementation (5% of food) lowered total body and abdominal fat mass, increased lean mass, and attenuated hypertension, impaired glucose and insulin tolerance, endothelial dysfunction, infiltration of inflammatory cells into heart and liver, fibrosis, increased cardiac stiffness, and nonalcoholic fatty liver disease in the high carbohydrate, high fat diet-fed rats. This study suggests that the insoluble fibre or protein in SC helps reverse diet-induced metabolic syndrome. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/25875119/A_green_algae_mixture_of_Scenedesmus_and_Schroederiella_attenuates_obesity_linked_metabolic_syndrome_in_rats_ L2 - http://www.mdpi.com/resolver?pii=nu7042771 DB - PRIME DP - Unbound Medicine ER -