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Prenatal and postnatal exposure to phthalate esters and asthma: a 9-year follow-up study of a taiwanese birth cohort.
PLoS One. 2015; 10(4):e0123309.Plos

Abstract

Previous studies have shown that phthalate exposure in childhood is associated with the development of respiratory problems. However, few studies have assessed the relative impact of prenatal and postnatal exposure to phthalates on the development of asthma later in childhood. Therefore, we assessed the impact of prenatal and postnatal phthalate exposure on the development of asthma and wheezing using a Taiwanese birth cohort. A total of 430 pregnant women were recruited, and 171 (39.8%) of them had their children followed when they were aged 2, 5, and 8 years. The International Study of Asthma and Allergies in Childhood questionnaire was used to assess asthma and wheezing symptoms and serum total immunoglobulin E levels were measured at 8 years of age. Urine samples were obtained from 136 women during their third trimester of pregnancy, 99 children at 2 years of age, and 110 children at 5 years. Four common phthalate monoester metabolites in maternal and children's urine were measured using liquid chromatography-electrospray ionization-tandem mass spectrometry. Maternal urinary mono-benzyl phthalate [MBzP] concentrations were associated with an increased occurrence of wheezing in boys at 8 years of age (odds ratio [OR] = 4.95 (95% CI 1.08-22.63)), for upper quintile compared to the others) after controlling for parental allergies and family members' smoking status. Urinary mono-2-ethylhexyl phthalate [MEHP] levels over the quintile at 2-year-old were associated with increased asthma occurrence (adjusted OR = 6.14 (1.17-32.13)) in boys. Similarly, the sum of di-2-ethyl-hexyl phthalate [DEHP] metabolites at 5 years was associated with asthma in boys (adjusted OR = 4.36 (1.01-18.86)). Urinary MEHP in maternal and 5-year-old children urine were significantly associated with increased IgE in allergic children at 8 years. Prenatal and postnatal exposure to phthalate was associated with the occurrence of asthma in children, particularly for boys.

Authors+Show Affiliations

Graduate Institute of Life Science, National Defense Medical Center, Taipei, Taiwan; Division of Environmental Health & Occupational Medicine, National Health Research Institutes, Miaoli, Taiwan.Division of Genetics, Department of Pediatrics, Chung Shan Medical University Hospital, Taichung, Taiwan.Division of Environmental Health & Occupational Medicine, National Health Research Institutes, Miaoli, Taiwan.Department of Pediatrics, Chung Shan Medical University Hospital, Taichung, Taiwan.Division of Environmental Health & Occupational Medicine, National Health Research Institutes, Miaoli, Taiwan.Division of Environmental Health & Occupational Medicine, National Health Research Institutes, Miaoli, Taiwan.Center for Environmental and Respiratory Health Research, University of Oulu, Oulu, Finland; Medical Research Center, Oulu, Finland.Graduate Institute of Life Science, National Defense Medical Center, Taipei, Taiwan; Division of Environmental Health & Occupational Medicine, National Health Research Institutes, Miaoli, Taiwan; Department of Public Health, College of Public Health, China Medical University, Taichung, Taiwan; School of Public Health, National Defense Medical Center, Taipei, Taiwan.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25875379

Citation

Ku, Hsiu Ying, et al. "Prenatal and Postnatal Exposure to Phthalate Esters and Asthma: a 9-year Follow-up Study of a Taiwanese Birth Cohort." PloS One, vol. 10, no. 4, 2015, pp. e0123309.
Ku HY, Su PH, Wen HJ, et al. Prenatal and postnatal exposure to phthalate esters and asthma: a 9-year follow-up study of a taiwanese birth cohort. PLoS One. 2015;10(4):e0123309.
Ku, H. Y., Su, P. H., Wen, H. J., Sun, H. L., Wang, C. J., Chen, H. Y., Jaakkola, J. J., & Wang, S. L. (2015). Prenatal and postnatal exposure to phthalate esters and asthma: a 9-year follow-up study of a taiwanese birth cohort. PloS One, 10(4), e0123309. https://doi.org/10.1371/journal.pone.0123309
Ku HY, et al. Prenatal and Postnatal Exposure to Phthalate Esters and Asthma: a 9-year Follow-up Study of a Taiwanese Birth Cohort. PLoS One. 2015;10(4):e0123309. PubMed PMID: 25875379.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prenatal and postnatal exposure to phthalate esters and asthma: a 9-year follow-up study of a taiwanese birth cohort. AU - Ku,Hsiu Ying, AU - Su,Pen Hua, AU - Wen,Hui Ju, AU - Sun,Hai Lun, AU - Wang,Chien Jen, AU - Chen,Hsiao Yen, AU - Jaakkola,Jouni J K, AU - Wang,Shu-Li, AU - ,, Y1 - 2015/04/13/ PY - 2014/04/25/received PY - 2015/03/02/accepted PY - 2015/4/16/entrez PY - 2015/4/16/pubmed PY - 2016/1/19/medline SP - e0123309 EP - e0123309 JF - PloS one JO - PLoS One VL - 10 IS - 4 N2 - Previous studies have shown that phthalate exposure in childhood is associated with the development of respiratory problems. However, few studies have assessed the relative impact of prenatal and postnatal exposure to phthalates on the development of asthma later in childhood. Therefore, we assessed the impact of prenatal and postnatal phthalate exposure on the development of asthma and wheezing using a Taiwanese birth cohort. A total of 430 pregnant women were recruited, and 171 (39.8%) of them had their children followed when they were aged 2, 5, and 8 years. The International Study of Asthma and Allergies in Childhood questionnaire was used to assess asthma and wheezing symptoms and serum total immunoglobulin E levels were measured at 8 years of age. Urine samples were obtained from 136 women during their third trimester of pregnancy, 99 children at 2 years of age, and 110 children at 5 years. Four common phthalate monoester metabolites in maternal and children's urine were measured using liquid chromatography-electrospray ionization-tandem mass spectrometry. Maternal urinary mono-benzyl phthalate [MBzP] concentrations were associated with an increased occurrence of wheezing in boys at 8 years of age (odds ratio [OR] = 4.95 (95% CI 1.08-22.63)), for upper quintile compared to the others) after controlling for parental allergies and family members' smoking status. Urinary mono-2-ethylhexyl phthalate [MEHP] levels over the quintile at 2-year-old were associated with increased asthma occurrence (adjusted OR = 6.14 (1.17-32.13)) in boys. Similarly, the sum of di-2-ethyl-hexyl phthalate [DEHP] metabolites at 5 years was associated with asthma in boys (adjusted OR = 4.36 (1.01-18.86)). Urinary MEHP in maternal and 5-year-old children urine were significantly associated with increased IgE in allergic children at 8 years. Prenatal and postnatal exposure to phthalate was associated with the occurrence of asthma in children, particularly for boys. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/25875379/Prenatal_and_postnatal_exposure_to_phthalate_esters_and_asthma:_a_9_year_follow_up_study_of_a_taiwanese_birth_cohort_ L2 - https://dx.plos.org/10.1371/journal.pone.0123309 DB - PRIME DP - Unbound Medicine ER -