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Preoperative carcinoembryonic antigen and prognosis of colorectal cancer. An independent prognostic factor still reliable.
Int Surg. 2015 Apr; 100(4):617-25.IS

Abstract

To evaluate whether, in a sample of patients radically treated for colorectal carcinoma, the preoperative determination of the carcinoembryonic antigen (p-CEA) may have a prognostic value and constitute an independent risk factor in relation to disease-free survival. The preoperative CEA seems to be related both to the staging of colorectal neoplasia and to the patient's prognosis, although this-to date-has not been conclusively demonstrated and is still a matter of intense debate in the scientific community. This is a retrospective analysis of prospectively collected data. A total of 395 patients were radically treated for colorectal carcinoma. The preoperative CEA was statistically compared with the 2010 American Joint Committee on Cancer (AJCC) staging, the T and N parameters, and grading. All parameters recorded in our database were tested for an association with disease-free survival (DFS). Only factors significantly associated (P < 0.05) with the DFS were used to build multivariate stepwise forward logistic regression models to establish their independent predictors. A statistically significant relationship was found between p-CEA and tumor staging (P < 0.001), T (P < 0.001) and N parameters (P = 0.006). In a multivariate analysis, the independent prognostic factors found were: p-CEA, stages N1 and N2 according to AJCC, and G3 grading (grade). A statistically significant difference (P < 0.001) was evident between the DFS of patients with normal and high p-CEA levels. Preoperative CEA makes a pre-operative selection possible of those patients for whom it is likely to be able to predict a more advanced staging.

Authors+Show Affiliations

1 Department of Surgical Sciences, Organ Transplantation and Advanced Technologies, University of Catania, Catania, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25875542

Citation

Li Destri, Giovanni, et al. "Preoperative Carcinoembryonic Antigen and Prognosis of Colorectal Cancer. an Independent Prognostic Factor Still Reliable." International Surgery, vol. 100, no. 4, 2015, pp. 617-25.
Li Destri G, Rubino AS, Latino R, et al. Preoperative carcinoembryonic antigen and prognosis of colorectal cancer. An independent prognostic factor still reliable. Int Surg. 2015;100(4):617-25.
Li Destri, G., Rubino, A. S., Latino, R., Giannone, F., Lanteri, R., Scilletta, B., & Di Cataldo, A. (2015). Preoperative carcinoembryonic antigen and prognosis of colorectal cancer. An independent prognostic factor still reliable. International Surgery, 100(4), 617-25. https://doi.org/10.9738/INTSURG-D-14-00100.1
Li Destri G, et al. Preoperative Carcinoembryonic Antigen and Prognosis of Colorectal Cancer. an Independent Prognostic Factor Still Reliable. Int Surg. 2015;100(4):617-25. PubMed PMID: 25875542.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preoperative carcinoembryonic antigen and prognosis of colorectal cancer. An independent prognostic factor still reliable. AU - Li Destri,Giovanni, AU - Rubino,Antonio Salvatore, AU - Latino,Rosalia, AU - Giannone,Fabio, AU - Lanteri,Raffaele, AU - Scilletta,Beniamino, AU - Di Cataldo,Antonio, PY - 2015/4/16/entrez PY - 2015/4/16/pubmed PY - 2016/11/3/medline KW - Colorectal carcinoma KW - Disease-free survival KW - Independent prognostic factor KW - Preoperative carcinoembryonic antigen SP - 617 EP - 25 JF - International surgery JO - Int Surg VL - 100 IS - 4 N2 - To evaluate whether, in a sample of patients radically treated for colorectal carcinoma, the preoperative determination of the carcinoembryonic antigen (p-CEA) may have a prognostic value and constitute an independent risk factor in relation to disease-free survival. The preoperative CEA seems to be related both to the staging of colorectal neoplasia and to the patient's prognosis, although this-to date-has not been conclusively demonstrated and is still a matter of intense debate in the scientific community. This is a retrospective analysis of prospectively collected data. A total of 395 patients were radically treated for colorectal carcinoma. The preoperative CEA was statistically compared with the 2010 American Joint Committee on Cancer (AJCC) staging, the T and N parameters, and grading. All parameters recorded in our database were tested for an association with disease-free survival (DFS). Only factors significantly associated (P < 0.05) with the DFS were used to build multivariate stepwise forward logistic regression models to establish their independent predictors. A statistically significant relationship was found between p-CEA and tumor staging (P < 0.001), T (P < 0.001) and N parameters (P = 0.006). In a multivariate analysis, the independent prognostic factors found were: p-CEA, stages N1 and N2 according to AJCC, and G3 grading (grade). A statistically significant difference (P < 0.001) was evident between the DFS of patients with normal and high p-CEA levels. Preoperative CEA makes a pre-operative selection possible of those patients for whom it is likely to be able to predict a more advanced staging. SN - 2520-2456 UR - https://www.unboundmedicine.com/medline/citation/25875542/Preoperative_carcinoembryonic_antigen_and_prognosis_of_colorectal_cancer__An_independent_prognostic_factor_still_reliable_ L2 - http://www.internationalsurgery.org/doi/10.9738/INTSURG-D-14-00100.1?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -