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Serum levels of adipocytokines in psoriasis patients receiving tumor necrosis factor-α inhibitors: results of a retrospective analysis.
Int J Dermatol. 2015 Jul; 54(7):839-45.IJ

Abstract

BACKGROUND

Adipocytokines are bioactive molecules that are deeply involved in the occurrence of atherosclerosis, obesity, and autoimmune inflammatory diseases.

OBJECTIVES

This study was conducted to evaluate the effects of tumor necrosis factor-α (TNF-α) inhibitors on serum levels of adipocytokines in patients with chronic plaque psoriasis.

METHODS

Serum levels of adiponectin, resistin, visfatin, leptin, TNF-α, and interleukin-6 (IL-6) were evaluated in sera obtained from 47 patients with psoriasis, both at baseline and after they had received TNF-α inhibitors for 24 weeks. Equivalent data were obtained for 39 control subjects matched by age, sex, body mass index, waist : hip ratio, geographical origin, Mediterranean dietary habits, and smoking habits.

RESULTS

At baseline, mean serum levels of TNF-α, IL-6, leptin, resistin, and visfatin were higher in the psoriasis group than in healthy controls; these differences were statistically significant (P < 0.05). Conversely, mean serum levels of adiponectin were significantly lower in patients with psoriasis than in controls (P < 0.0001). Serum levels of adipocytokines did not linearly correlate with anthropometric indices in psoriasis patients (P > 0.05), except in the case of leptin, for which serum levels were related to waist : hip ratio in both men and women (P < 0.05). After 24 weeks of treatment, although serum levels of proinflammatory adipocytokines were decreased, only that of leptin showed a statistically significant reduction (P = 0.0003). Serum levels of adiponectin, an anti-inflammatory adipocytokine, were only mildly increased and persisted at a significantly lower level than in healthy controls (P > 0.005).

CONCLUSIONS

Patients with psoriasis show an imbalance between pro- and anti-inflammatory adipocytokines, which is reduced but not normalized after administration of TNF-α inhibitors for 24 weeks. This partial rebalancing seems to be mainly related to a reduction in proinflammatory adipocytokines, rather than an increase in anti-inflammatory adipocytokines.

Authors+Show Affiliations

Dermatology Unit, Department of Clinical and Molecular Sciences, Polytechnic Marche University, Ancona, Italy.Dermatology Unit, Department of Clinical and Molecular Sciences, Polytechnic Marche University, Ancona, Italy.Dermatology Unit, Department of Clinical and Molecular Sciences, Polytechnic Marche University, Ancona, Italy.Metabolic Diseases and Diabetology Unit, Italian National Research Center on Aging (INRCA), Ancona, Italy.Metabolic Diseases and Diabetology Unit, Italian National Research Center on Aging (INRCA), Ancona, Italy.Experimental Models in Clinical Pathology, INRCA, Ancona, Italy.Dermatology Unit, Department of Clinical and Molecular Sciences, Polytechnic Marche University, Ancona, Italy.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25877149

Citation

Campanati, Anna, et al. "Serum Levels of Adipocytokines in Psoriasis Patients Receiving Tumor Necrosis Factor-α Inhibitors: Results of a Retrospective Analysis." International Journal of Dermatology, vol. 54, no. 7, 2015, pp. 839-45.
Campanati A, Ganzetti G, Giuliodori K, et al. Serum levels of adipocytokines in psoriasis patients receiving tumor necrosis factor-α inhibitors: results of a retrospective analysis. Int J Dermatol. 2015;54(7):839-45.
Campanati, A., Ganzetti, G., Giuliodori, K., Marra, M., Bonfigli, A., Testa, R., & Offidani, A. (2015). Serum levels of adipocytokines in psoriasis patients receiving tumor necrosis factor-α inhibitors: results of a retrospective analysis. International Journal of Dermatology, 54(7), 839-45. https://doi.org/10.1111/ijd.12706
Campanati A, et al. Serum Levels of Adipocytokines in Psoriasis Patients Receiving Tumor Necrosis Factor-α Inhibitors: Results of a Retrospective Analysis. Int J Dermatol. 2015;54(7):839-45. PubMed PMID: 25877149.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum levels of adipocytokines in psoriasis patients receiving tumor necrosis factor-α inhibitors: results of a retrospective analysis. AU - Campanati,Anna, AU - Ganzetti,Giulia, AU - Giuliodori,Katia, AU - Marra,Maurizio, AU - Bonfigli,Annarita, AU - Testa,Roberto, AU - Offidani,Annamaria, Y1 - 2015/04/15/ PY - 2013/09/16/received PY - 2014/01/15/revised PY - 2014/03/08/accepted PY - 2015/4/17/entrez PY - 2015/4/17/pubmed PY - 2016/3/26/medline SP - 839 EP - 45 JF - International journal of dermatology JO - Int. J. Dermatol. VL - 54 IS - 7 N2 - BACKGROUND: Adipocytokines are bioactive molecules that are deeply involved in the occurrence of atherosclerosis, obesity, and autoimmune inflammatory diseases. OBJECTIVES: This study was conducted to evaluate the effects of tumor necrosis factor-α (TNF-α) inhibitors on serum levels of adipocytokines in patients with chronic plaque psoriasis. METHODS: Serum levels of adiponectin, resistin, visfatin, leptin, TNF-α, and interleukin-6 (IL-6) were evaluated in sera obtained from 47 patients with psoriasis, both at baseline and after they had received TNF-α inhibitors for 24 weeks. Equivalent data were obtained for 39 control subjects matched by age, sex, body mass index, waist : hip ratio, geographical origin, Mediterranean dietary habits, and smoking habits. RESULTS: At baseline, mean serum levels of TNF-α, IL-6, leptin, resistin, and visfatin were higher in the psoriasis group than in healthy controls; these differences were statistically significant (P < 0.05). Conversely, mean serum levels of adiponectin were significantly lower in patients with psoriasis than in controls (P < 0.0001). Serum levels of adipocytokines did not linearly correlate with anthropometric indices in psoriasis patients (P > 0.05), except in the case of leptin, for which serum levels were related to waist : hip ratio in both men and women (P < 0.05). After 24 weeks of treatment, although serum levels of proinflammatory adipocytokines were decreased, only that of leptin showed a statistically significant reduction (P = 0.0003). Serum levels of adiponectin, an anti-inflammatory adipocytokine, were only mildly increased and persisted at a significantly lower level than in healthy controls (P > 0.005). CONCLUSIONS: Patients with psoriasis show an imbalance between pro- and anti-inflammatory adipocytokines, which is reduced but not normalized after administration of TNF-α inhibitors for 24 weeks. This partial rebalancing seems to be mainly related to a reduction in proinflammatory adipocytokines, rather than an increase in anti-inflammatory adipocytokines. SN - 1365-4632 UR - https://www.unboundmedicine.com/medline/citation/25877149/Serum_levels_of_adipocytokines_in_psoriasis_patients_receiving_tumor_necrosis_factor_α_inhibitors:_results_of_a_retrospective_analysis_ L2 - https://doi.org/10.1111/ijd.12706 DB - PRIME DP - Unbound Medicine ER -