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Neglected tropical diseases among the Association of Southeast Asian Nations (ASEAN): overview and update.
PLoS Negl Trop Dis. 2015 Apr; 9(4):e0003575.PN

Abstract

The ten member states of the Association of Southeast Asian Nations (ASEAN) constitute an economic powerhouse, yet these countries also harbor a mostly hidden burden of poverty and neglected tropical diseases (NTDs). Almost 200 million people live in extreme poverty in ASEAN countries, mostly in the low or lower middle-income countries of Indonesia, the Philippines, Myanmar, Viet Nam, and Cambodia, and many of them are affected by at least one NTD. However, NTDs are prevalent even among upper middle-income ASEAN countries such as Malaysia and Thailand, especially among the indigenous populations. The three major intestinal helminth infections are the most common NTDs; each helminthiasis is associated with approximately 100 million infections in the region. In addition, more than 10 million people suffer from either liver or intestinal fluke infections, as well as schistosomiasis and lymphatic filariasis (LF). Intestinal protozoan infections are widespread, while leishmaniasis has emerged in Thailand, and zoonotic malaria (Plasmodium knowlesi infection) causes severe morbidity in Malaysia. Melioidosis has emerged as an important bacterial NTD, as have selected rickettsial infections, and leptospirosis. Leprosy, yaws, and trachoma are still endemic in focal areas. Almost 70 million cases of dengue fever occur annually in ASEAN countries, such that this arboviral infection is now one of the most common and economically important NTDs in the region. A number of other arboviral and zoonotic viral infections have also emerged, including Japanese encephalitis; tick-borne viral infections; Nipah virus, a zoonosis present in fruit bats; and enterovirus 71 infection. There are urgent needs to expand surveillance activities in ASEAN countries, as well as to ensure mass drug administration is provided to populations at risk for intestinal helminth and fluke infections, LF, trachoma, and yaws. An ASEAN Network for Drugs, Diagnostics, Vaccines, and Traditional Medicines Innovation provides a policy framework for the development of new control and elimination tools. Together with prominent research institutions and universities, the World Health Organization (WHO), and its regional offices, these organizations could implement important public health improvements through NTD control and elimination in the coming decade.

Authors+Show Affiliations

Sabin Vaccine Institute and Texas Children's Hospital Center for Vaccine Development, Departments of Pediatrics and Molecular Virology and Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston, Texas, United States of America; Department of Biology, Baylor University, Waco, Texas, United States of America; James A. Baker III Institute for Public Policy, Rice University, Houston, Texas, United States of America.Sabin Vaccine Institute and Texas Children's Hospital Center for Vaccine Development, Departments of Pediatrics and Molecular Virology and Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston, Texas, United States of America; Department of Biology, Baylor University, Waco, Texas, United States of America.Sabin Vaccine Institute and Texas Children's Hospital Center for Vaccine Development, Departments of Pediatrics and Molecular Virology and Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston, Texas, United States of America.Tropical Infectious Diseases Research and Education Centre, Department of Medical Microbiology, University of Malaya, Kuala Lumpur, Malaysia.Department of Parasitology, University of Malaya, Kuala Lumpur, Malaysia.Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, College of Medicine, Gainesville, Florida, United States of America.Tropical Infectious Diseases Research and Education Centre, Department of Medical Microbiology, University of Malaya, Kuala Lumpur, Malaysia.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

25880767

Citation

Hotez, Peter J., et al. "Neglected Tropical Diseases Among the Association of Southeast Asian Nations (ASEAN): Overview and Update." PLoS Neglected Tropical Diseases, vol. 9, no. 4, 2015, pp. e0003575.
Hotez PJ, Bottazzi ME, Strych U, et al. Neglected tropical diseases among the Association of Southeast Asian Nations (ASEAN): overview and update. PLoS Negl Trop Dis. 2015;9(4):e0003575.
Hotez, P. J., Bottazzi, M. E., Strych, U., Chang, L. Y., Lim, Y. A., Goodenow, M. M., & AbuBakar, S. (2015). Neglected tropical diseases among the Association of Southeast Asian Nations (ASEAN): overview and update. PLoS Neglected Tropical Diseases, 9(4), e0003575. https://doi.org/10.1371/journal.pntd.0003575
Hotez PJ, et al. Neglected Tropical Diseases Among the Association of Southeast Asian Nations (ASEAN): Overview and Update. PLoS Negl Trop Dis. 2015;9(4):e0003575. PubMed PMID: 25880767.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neglected tropical diseases among the Association of Southeast Asian Nations (ASEAN): overview and update. AU - Hotez,Peter J, AU - Bottazzi,Maria Elena, AU - Strych,Ulrich, AU - Chang,Li-Yen, AU - Lim,Yvonne A L, AU - Goodenow,Maureen M, AU - AbuBakar,Sazaly, Y1 - 2015/04/16/ PY - 2015/4/17/entrez PY - 2015/4/17/pubmed PY - 2015/12/19/medline SP - e0003575 EP - e0003575 JF - PLoS neglected tropical diseases JO - PLoS Negl Trop Dis VL - 9 IS - 4 N2 - The ten member states of the Association of Southeast Asian Nations (ASEAN) constitute an economic powerhouse, yet these countries also harbor a mostly hidden burden of poverty and neglected tropical diseases (NTDs). Almost 200 million people live in extreme poverty in ASEAN countries, mostly in the low or lower middle-income countries of Indonesia, the Philippines, Myanmar, Viet Nam, and Cambodia, and many of them are affected by at least one NTD. However, NTDs are prevalent even among upper middle-income ASEAN countries such as Malaysia and Thailand, especially among the indigenous populations. The three major intestinal helminth infections are the most common NTDs; each helminthiasis is associated with approximately 100 million infections in the region. In addition, more than 10 million people suffer from either liver or intestinal fluke infections, as well as schistosomiasis and lymphatic filariasis (LF). Intestinal protozoan infections are widespread, while leishmaniasis has emerged in Thailand, and zoonotic malaria (Plasmodium knowlesi infection) causes severe morbidity in Malaysia. Melioidosis has emerged as an important bacterial NTD, as have selected rickettsial infections, and leptospirosis. Leprosy, yaws, and trachoma are still endemic in focal areas. Almost 70 million cases of dengue fever occur annually in ASEAN countries, such that this arboviral infection is now one of the most common and economically important NTDs in the region. A number of other arboviral and zoonotic viral infections have also emerged, including Japanese encephalitis; tick-borne viral infections; Nipah virus, a zoonosis present in fruit bats; and enterovirus 71 infection. There are urgent needs to expand surveillance activities in ASEAN countries, as well as to ensure mass drug administration is provided to populations at risk for intestinal helminth and fluke infections, LF, trachoma, and yaws. An ASEAN Network for Drugs, Diagnostics, Vaccines, and Traditional Medicines Innovation provides a policy framework for the development of new control and elimination tools. Together with prominent research institutions and universities, the World Health Organization (WHO), and its regional offices, these organizations could implement important public health improvements through NTD control and elimination in the coming decade. SN - 1935-2735 UR - https://www.unboundmedicine.com/medline/citation/25880767/full_citation L2 - http://dx.plos.org/10.1371/journal.pntd.0003575 DB - PRIME DP - Unbound Medicine ER -