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Helicobacter pylori infection is not associated with fatty liver disease including non-alcoholic fatty liver disease: a large-scale cross-sectional study in Japan.
BMC Gastroenterol. 2015 Feb 19; 15:25.BG

Abstract

BACKGROUND

Fatty liver disease (FLD) including non-alcoholic fatty liver disease (NAFLD), a rapidly emerging and widely recognized liver disease today, is regarded as a hepatic manifestation of metabolic syndrome. Helicobacter pylori, one of the most common pathogens worldwide, has been reported to be associated with metabolic syndrome, but whether there is a direct association with FLD is as of yet unclear. The aim of this study was to clarify the association of FLD and NAFLD with causative background factors including Helicobacter pylori infection.

METHODS

This was a cross-sectional study of Japanese adults who received medical checkups at a single medical center in 2010.Univariate and multivariate statistical analysis was performed to evaluate background factors for ultrasonography diagnosed FLD. Subjects free from alcohol influence were similarly analyzed for NAFLD.

RESULTS

Of a total of 13,737 subjects, FLD was detected in 1,456 of 6,318 females (23.0 %) and 3,498 of 7,419 males (47.1%). Multivariable analyses revealed that body mass index (standardized coefficients of females and males (β-F/M) =143.5/102.5), serum ALT (β-F/M = 25.8/75.7), age (β-F/M = 34.3/17.2), and platelet count (β-F/M = 17.8/15.2) were positively associated with FLD in both genders. Of the 5,289 subjects free from alcohol influence, NAFLD was detected in 881 of 3,473 females (25.4%) and 921 of 1,816 males (50.7%). Body mass index (β-F/M = 113.3/55.3), serum ALT (β-F/M = 21.6/53.8), and platelet count (β-F/M = 13.8/11.8) were positively associated with NAFLD in both genders. Metabolic syndrome was positively associated with FLD and NAFLD only in males. In contrast, Helicobacter pylori infection status was neither associated with FLD nor NAFLD regardless of gender.

CONCLUSIONS

Body mass index, serum ALT and platelet count were significantly associated with FLD and NAFLD, whereas infection of Helicobacter pylori was not.

Authors+Show Affiliations

Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. koxin-tky@umin.org.Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. yutakahashi-tky@umin.ac.jp.Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. nyamamic-tky@umin.ac.jp.Kameda Medical Center Makuhari (CD-2, 1-3, Nakase, Mihama-ku, Chiba-city, Japan. tshimamoto@gmail.com.Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. enooku.tky@gmail.com.Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. fujinaga-tky@umin.net.Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. tsutsumi-tky@umin.ac.jp.Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. shintani-tky@umin.ac.jp.Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. ysakaguchi0116@yahoo.co.jp.Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. satoshi-tky@umin.ac.jp.Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. kodashima-tky@umin.ac.jp.Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. mtfujish-kkr@umin.ac.jp.Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. moriya-tky@umin.ac.jp.Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. hyotsu-tky@umin.ac.jp.Kameda Medical Center Makuhari (CD-2, 1-3, Nakase, Mihama-ku, Chiba-city, Japan. ToruMitsushima@yahoo.co.jp.Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. kkoike-tky@umin.ac.jp.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25880912

Citation

Okushin, Kazuya, et al. "Helicobacter Pylori Infection Is Not Associated With Fatty Liver Disease Including Non-alcoholic Fatty Liver Disease: a Large-scale Cross-sectional Study in Japan." BMC Gastroenterology, vol. 15, 2015, p. 25.
Okushin K, Takahashi Y, Yamamichi N, et al. Helicobacter pylori infection is not associated with fatty liver disease including non-alcoholic fatty liver disease: a large-scale cross-sectional study in Japan. BMC Gastroenterol. 2015;15:25.
Okushin, K., Takahashi, Y., Yamamichi, N., Shimamoto, T., Enooku, K., Fujinaga, H., Tsutsumi, T., Shintani, Y., Sakaguchi, Y., Ono, S., Kodashima, S., Fujishiro, M., Moriya, K., Yotsuyanagi, H., Mitsushima, T., & Koike, K. (2015). Helicobacter pylori infection is not associated with fatty liver disease including non-alcoholic fatty liver disease: a large-scale cross-sectional study in Japan. BMC Gastroenterology, 15, 25. https://doi.org/10.1186/s12876-015-0247-9
Okushin K, et al. Helicobacter Pylori Infection Is Not Associated With Fatty Liver Disease Including Non-alcoholic Fatty Liver Disease: a Large-scale Cross-sectional Study in Japan. BMC Gastroenterol. 2015 Feb 19;15:25. PubMed PMID: 25880912.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Helicobacter pylori infection is not associated with fatty liver disease including non-alcoholic fatty liver disease: a large-scale cross-sectional study in Japan. AU - Okushin,Kazuya, AU - Takahashi,Yu, AU - Yamamichi,Nobutake, AU - Shimamoto,Takeshi, AU - Enooku,Kenichiro, AU - Fujinaga,Hidetaka, AU - Tsutsumi,Takeya, AU - Shintani,Yoshizumi, AU - Sakaguchi,Yoshiki, AU - Ono,Satoshi, AU - Kodashima,Shinya, AU - Fujishiro,Mitsuhiro, AU - Moriya,Kyoji, AU - Yotsuyanagi,Hiroshi, AU - Mitsushima,Toru, AU - Koike,Kazuhiko, Y1 - 2015/02/19/ PY - 2015/01/19/received PY - 2015/02/02/accepted PY - 2015/4/17/entrez PY - 2015/4/17/pubmed PY - 2016/2/24/medline SP - 25 EP - 25 JF - BMC gastroenterology JO - BMC Gastroenterol VL - 15 N2 - BACKGROUND: Fatty liver disease (FLD) including non-alcoholic fatty liver disease (NAFLD), a rapidly emerging and widely recognized liver disease today, is regarded as a hepatic manifestation of metabolic syndrome. Helicobacter pylori, one of the most common pathogens worldwide, has been reported to be associated with metabolic syndrome, but whether there is a direct association with FLD is as of yet unclear. The aim of this study was to clarify the association of FLD and NAFLD with causative background factors including Helicobacter pylori infection. METHODS: This was a cross-sectional study of Japanese adults who received medical checkups at a single medical center in 2010.Univariate and multivariate statistical analysis was performed to evaluate background factors for ultrasonography diagnosed FLD. Subjects free from alcohol influence were similarly analyzed for NAFLD. RESULTS: Of a total of 13,737 subjects, FLD was detected in 1,456 of 6,318 females (23.0 %) and 3,498 of 7,419 males (47.1%). Multivariable analyses revealed that body mass index (standardized coefficients of females and males (β-F/M) =143.5/102.5), serum ALT (β-F/M = 25.8/75.7), age (β-F/M = 34.3/17.2), and platelet count (β-F/M = 17.8/15.2) were positively associated with FLD in both genders. Of the 5,289 subjects free from alcohol influence, NAFLD was detected in 881 of 3,473 females (25.4%) and 921 of 1,816 males (50.7%). Body mass index (β-F/M = 113.3/55.3), serum ALT (β-F/M = 21.6/53.8), and platelet count (β-F/M = 13.8/11.8) were positively associated with NAFLD in both genders. Metabolic syndrome was positively associated with FLD and NAFLD only in males. In contrast, Helicobacter pylori infection status was neither associated with FLD nor NAFLD regardless of gender. CONCLUSIONS: Body mass index, serum ALT and platelet count were significantly associated with FLD and NAFLD, whereas infection of Helicobacter pylori was not. SN - 1471-230X UR - https://www.unboundmedicine.com/medline/citation/25880912/Helicobacter_pylori_infection_is_not_associated_with_fatty_liver_disease_including_non_alcoholic_fatty_liver_disease:_a_large_scale_cross_sectional_study_in_Japan_ L2 - https://bmcgastroenterol.biomedcentral.com/articles/10.1186/s12876-015-0247-9 DB - PRIME DP - Unbound Medicine ER -