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Complications of cirrhosis. A 50 years flashback.
Scand J Gastroenterol. 2015 Jun; 50(6):763-80.SJ

Abstract

In patients with cirrhosis and portal hypertension, it is largely the frequency and severity of complications relating to the diseased liver, degree of portal hypertension and hemodynamic derangement that determine the prognosis. It can be considered as a multiple organ failure that apart from the liver involves the heart, lungs, kidneys, the immune systems and other organ systems. Progressive fibrosis of the liver and subsequent metabolic impairment leads to a systemic and splanchnic arteriolar vasodilatation. With the progression of the disease development of portal hypertension leads to formation of esophageal varices and ascites. The circulation becomes hyperdynamic with cardiac, pulmonary as well as renal consequences for dysfunction and reduced survival. Infections and a changed cardiac function known as cirrhotic cardiomyopathy may be involved in further aggravation of other complications such as renal failure precipitating the hepatorenal syndrome. Patients with end-stage liver disease and related complications as for example the hepatopulmonary syndrome can only radically be treated by liver transplantation.

Authors+Show Affiliations

Department of Clinical Physiology and Nuclear Medicine 239, Faculty of Health Sciences, Center for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital, University of Copenhagen , Hvidovre , Denmark.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

25881709

Citation

Møller, Søren, and Flemming Bendtsen. "Complications of Cirrhosis. a 50 Years Flashback." Scandinavian Journal of Gastroenterology, vol. 50, no. 6, 2015, pp. 763-80.
Møller S, Bendtsen F. Complications of cirrhosis. A 50 years flashback. Scand J Gastroenterol. 2015;50(6):763-80.
Møller, S., & Bendtsen, F. (2015). Complications of cirrhosis. A 50 years flashback. Scandinavian Journal of Gastroenterology, 50(6), 763-80. https://doi.org/10.3109/00365521.2015.1021709
Møller S, Bendtsen F. Complications of Cirrhosis. a 50 Years Flashback. Scand J Gastroenterol. 2015;50(6):763-80. PubMed PMID: 25881709.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Complications of cirrhosis. A 50 years flashback. AU - Møller,Søren, AU - Bendtsen,Flemming, Y1 - 2015/04/16/ PY - 2015/4/18/entrez PY - 2015/4/18/pubmed PY - 2016/2/3/medline KW - arterial vasodilatation KW - ascites KW - cirrhosis KW - cirrhotic cardiomyopathy KW - esophageal varices KW - hemodynamics KW - hepatic encephalopathy KW - hepatopulmonary syndrome KW - hepatorenal syndrome KW - portal hypertension KW - portopulmonary hypertension KW - vasoactive substances SP - 763 EP - 80 JF - Scandinavian journal of gastroenterology JO - Scand J Gastroenterol VL - 50 IS - 6 N2 - In patients with cirrhosis and portal hypertension, it is largely the frequency and severity of complications relating to the diseased liver, degree of portal hypertension and hemodynamic derangement that determine the prognosis. It can be considered as a multiple organ failure that apart from the liver involves the heart, lungs, kidneys, the immune systems and other organ systems. Progressive fibrosis of the liver and subsequent metabolic impairment leads to a systemic and splanchnic arteriolar vasodilatation. With the progression of the disease development of portal hypertension leads to formation of esophageal varices and ascites. The circulation becomes hyperdynamic with cardiac, pulmonary as well as renal consequences for dysfunction and reduced survival. Infections and a changed cardiac function known as cirrhotic cardiomyopathy may be involved in further aggravation of other complications such as renal failure precipitating the hepatorenal syndrome. Patients with end-stage liver disease and related complications as for example the hepatopulmonary syndrome can only radically be treated by liver transplantation. SN - 1502-7708 UR - https://www.unboundmedicine.com/medline/citation/25881709/Complications_of_cirrhosis__A_50_years_flashback_ L2 - https://www.tandfonline.com/doi/full/10.3109/00365521.2015.1021709 DB - PRIME DP - Unbound Medicine ER -