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Oxidized HDL and LDL in adolescents with type 2 diabetes compared to normal weight and obese peers.
J Diabetes Complications 2015; 29(5):679-85JD

Abstract

OBJECTIVE

Obesity and type 2 diabetes mellitus (T2DM) are associated with oxidative stress. Oxidative damage of high-density lipoprotein (oxHDL) leads to a dysfunctional molecule, potentially a mediator and/or marker of cardiometabolic disease. We tested the hypothesis that circulating concentration of oxHDL is higher in obese (Ob) or T2DM adolescents compared to normal-weight (NW) peers.

METHODS

In 37 NW, 38 Ob, and 42 T2DM adolescents, ages 11-18 y, fasting concentrations of HDL and LDL cholesterol, oxHDL, oxidized low-density lipoprotein (oxLDL), and myeloperoxidase (MPO) were measured.

RESULTS

Compared to the NW group, oxHDL in the Ob group was not different, but was 65% higher (p < 0.01) in the T2DM group. Within the T2DM group oxHDL was higher in boys than in girls, but this sex difference was not evident in NW or Ob groups. OxLDL was 23% higher in Ob (p = 0.02), and 56% higher in T2DM (p < 0.01) versus NW and did not differ between boys and girls. MPO was not different between NW and Ob but was 88% (p < 0.02) higher in T2DM compared to NW. Contrary to our hypothesis MPO and insulin resistance (HOMA-IR) were not correlated with oxHDL. OxHDL was positively associated with oxLDL and lean body mass while oxLDL was positively associated with apolipoprotein B, triglycerides, HOMA-IR and trunk fat.

CONCLUSIONS

The higher concentrations of oxHDL and oxLDL, along with higher MPO in children with T2DM reflect higher oxidative stress compared with obesity alone and potentially increased cardiovascular disease risk in youth with T2DM.

Authors+Show Affiliations

Pediatrics, Section of Diabetes/Endocrinology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.Pediatrics, Section of Diabetes/Endocrinology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.Pediatrics, Section of Diabetes/Endocrinology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.Pediatrics, Biomedical and Behavioral Methodology Core, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.Pediatrics, Section of Diabetes/Endocrinology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.Pediatrics, Section of Diabetes/Endocrinology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma. Electronic address: kevin-short@ouhsc.edu.

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25881918

Citation

Marin, Monica T., et al. "Oxidized HDL and LDL in Adolescents With Type 2 Diabetes Compared to Normal Weight and Obese Peers." Journal of Diabetes and Its Complications, vol. 29, no. 5, 2015, pp. 679-85.
Marin MT, Dasari PS, Tryggestad JB, et al. Oxidized HDL and LDL in adolescents with type 2 diabetes compared to normal weight and obese peers. J Diabetes Complicat. 2015;29(5):679-85.
Marin, M. T., Dasari, P. S., Tryggestad, J. B., Aston, C. E., Teague, A. M., & Short, K. R. (2015). Oxidized HDL and LDL in adolescents with type 2 diabetes compared to normal weight and obese peers. Journal of Diabetes and Its Complications, 29(5), pp. 679-85. doi:10.1016/j.jdiacomp.2015.03.015.
Marin MT, et al. Oxidized HDL and LDL in Adolescents With Type 2 Diabetes Compared to Normal Weight and Obese Peers. J Diabetes Complicat. 2015;29(5):679-85. PubMed PMID: 25881918.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidized HDL and LDL in adolescents with type 2 diabetes compared to normal weight and obese peers. AU - Marin,Monica T, AU - Dasari,Paul S, AU - Tryggestad,Jeanie B, AU - Aston,Christopher E, AU - Teague,April M, AU - Short,Kevin R, Y1 - 2015/04/06/ PY - 2014/11/17/received PY - 2015/02/16/revised PY - 2015/03/05/accepted PY - 2015/4/18/entrez PY - 2015/4/18/pubmed PY - 2016/3/2/medline KW - Cardiovascular disease KW - Insulin resistance KW - Obesity KW - Oxidative stress KW - Youth SP - 679 EP - 85 JF - Journal of diabetes and its complications JO - J. Diabetes Complicat. VL - 29 IS - 5 N2 - OBJECTIVE: Obesity and type 2 diabetes mellitus (T2DM) are associated with oxidative stress. Oxidative damage of high-density lipoprotein (oxHDL) leads to a dysfunctional molecule, potentially a mediator and/or marker of cardiometabolic disease. We tested the hypothesis that circulating concentration of oxHDL is higher in obese (Ob) or T2DM adolescents compared to normal-weight (NW) peers. METHODS: In 37 NW, 38 Ob, and 42 T2DM adolescents, ages 11-18 y, fasting concentrations of HDL and LDL cholesterol, oxHDL, oxidized low-density lipoprotein (oxLDL), and myeloperoxidase (MPO) were measured. RESULTS: Compared to the NW group, oxHDL in the Ob group was not different, but was 65% higher (p < 0.01) in the T2DM group. Within the T2DM group oxHDL was higher in boys than in girls, but this sex difference was not evident in NW or Ob groups. OxLDL was 23% higher in Ob (p = 0.02), and 56% higher in T2DM (p < 0.01) versus NW and did not differ between boys and girls. MPO was not different between NW and Ob but was 88% (p < 0.02) higher in T2DM compared to NW. Contrary to our hypothesis MPO and insulin resistance (HOMA-IR) were not correlated with oxHDL. OxHDL was positively associated with oxLDL and lean body mass while oxLDL was positively associated with apolipoprotein B, triglycerides, HOMA-IR and trunk fat. CONCLUSIONS: The higher concentrations of oxHDL and oxLDL, along with higher MPO in children with T2DM reflect higher oxidative stress compared with obesity alone and potentially increased cardiovascular disease risk in youth with T2DM. SN - 1873-460X UR - https://www.unboundmedicine.com/medline/citation/25881918/Oxidized_HDL_and_LDL_in_adolescents_with_type_2_diabetes_compared_to_normal_weight_and_obese_peers_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1056-8727(15)00111-7 DB - PRIME DP - Unbound Medicine ER -