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Association between alcohol consumption and the risk of ovarian cancer: a meta-analysis of prospective observational studies.
BMC Public Health 2015; 15:223BP

Abstract

BACKGROUND

Alcohol consumption has been inconsistently associated with the risk of ovarian cancer. The purpose of this study was to summarize the data from prospective cohort studies on the relationship between alcohol consumption and ovarian cancer using a meta-analytic approach.

METHODS

We performed electronic searches of PubMed, Embase, and the Cochrane Library in May 2014 to identify studies that examined the effects of alcohol consumption on the incidence of ovarian cancer. Only prospective cohort studies that reported effect estimates about the incidence of ovarian cancer with 95% confidence intervals (CIs) of alcohol intake were included.

RESULTS

Collectively, we included 13 prospective studies that reported on data from 1,996,841 individuals and included 5,857 cases of ovarian cancer. Alcohol consumption had little to no effect on ovarian cancer incidence when compared to non-drinkers (risk ratio [RR], 1.03; 95% CI, 0.96-1.10; P = 0.473). Similarly, low (RR, 0.96; 95% CI, 0.93-1.00; P = 0.059), moderate (RR, 1.08; 95% CI, 0.92-1.27; P = 0.333), and heavy (RR, 0.99; 95% CI, 0.88-1.12; P = 0.904) alcohol consumption was not associated with the risk of ovarian cancer. Furthermore, subgroup analyses suggested that low alcohol intake was associated with a reduced risk of ovarian cancer whereas heavy alcohol intake was associated with an increased risk of ovarian cancer in multiple subpopulations.

CONCLUSIONS

Our study suggests that alcohol intake is not associated with an increased risk of ovarian cancer. Subgroup analyses indicated that alcohol consumption might be associated with the risk of ovarian cancer in specific population or in studies with specific characteristics.

Authors+Show Affiliations

Shenyang Women and Children Health Centre, No. 74, Chongshan Road, Huanggu District, 110032, Shenyang City, Liao Ning, China. huangyanhongshen@126.com.Shenyang Women and Children Health Centre, No. 74, Chongshan Road, Huanggu District, 110032, Shenyang City, Liao Ning, China. lijingshen@126.com.Shenyang Women and Children Health Centre, No. 74, Chongshan Road, Huanggu District, 110032, Shenyang City, Liao Ning, China. luanhongshen@126.com.Shenyang Women and Children Health Centre, No. 74, Chongshan Road, Huanggu District, 110032, Shenyang City, Liao Ning, China. huangshanshanshen@126.com.Shenyang Women and Children Health Centre, No. 74, Chongshan Road, Huanggu District, 110032, Shenyang City, Liao Ning, China. liyanwomen@126.com.Shenyang Women and Children Health Centre, No. 74, Chongshan Road, Huanggu District, 110032, Shenyang City, Liao Ning, China. lijushen@126.com.

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

25885863

Citation

Yan-Hong, Huang, et al. "Association Between Alcohol Consumption and the Risk of Ovarian Cancer: a Meta-analysis of Prospective Observational Studies." BMC Public Health, vol. 15, 2015, p. 223.
Yan-Hong H, Jing L, Hong L, et al. Association between alcohol consumption and the risk of ovarian cancer: a meta-analysis of prospective observational studies. BMC Public Health. 2015;15:223.
Yan-Hong, H., Jing, L., Hong, L., Shan-Shan, H., Yan, L., & Ju, L. (2015). Association between alcohol consumption and the risk of ovarian cancer: a meta-analysis of prospective observational studies. BMC Public Health, 15, p. 223. doi:10.1186/s12889-015-1355-8.
Yan-Hong H, et al. Association Between Alcohol Consumption and the Risk of Ovarian Cancer: a Meta-analysis of Prospective Observational Studies. BMC Public Health. 2015 Mar 7;15:223. PubMed PMID: 25885863.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between alcohol consumption and the risk of ovarian cancer: a meta-analysis of prospective observational studies. AU - Yan-Hong,Huang, AU - Jing,Li, AU - Hong,Luan, AU - Shan-Shan,Huang, AU - Yan,Li, AU - Ju,Li, Y1 - 2015/03/07/ PY - 2014/08/01/received PY - 2015/01/05/accepted PY - 2015/4/18/entrez PY - 2015/4/18/pubmed PY - 2015/12/15/medline SP - 223 EP - 223 JF - BMC public health JO - BMC Public Health VL - 15 N2 - BACKGROUND: Alcohol consumption has been inconsistently associated with the risk of ovarian cancer. The purpose of this study was to summarize the data from prospective cohort studies on the relationship between alcohol consumption and ovarian cancer using a meta-analytic approach. METHODS: We performed electronic searches of PubMed, Embase, and the Cochrane Library in May 2014 to identify studies that examined the effects of alcohol consumption on the incidence of ovarian cancer. Only prospective cohort studies that reported effect estimates about the incidence of ovarian cancer with 95% confidence intervals (CIs) of alcohol intake were included. RESULTS: Collectively, we included 13 prospective studies that reported on data from 1,996,841 individuals and included 5,857 cases of ovarian cancer. Alcohol consumption had little to no effect on ovarian cancer incidence when compared to non-drinkers (risk ratio [RR], 1.03; 95% CI, 0.96-1.10; P = 0.473). Similarly, low (RR, 0.96; 95% CI, 0.93-1.00; P = 0.059), moderate (RR, 1.08; 95% CI, 0.92-1.27; P = 0.333), and heavy (RR, 0.99; 95% CI, 0.88-1.12; P = 0.904) alcohol consumption was not associated with the risk of ovarian cancer. Furthermore, subgroup analyses suggested that low alcohol intake was associated with a reduced risk of ovarian cancer whereas heavy alcohol intake was associated with an increased risk of ovarian cancer in multiple subpopulations. CONCLUSIONS: Our study suggests that alcohol intake is not associated with an increased risk of ovarian cancer. Subgroup analyses indicated that alcohol consumption might be associated with the risk of ovarian cancer in specific population or in studies with specific characteristics. SN - 1471-2458 UR - https://www.unboundmedicine.com/medline/citation/25885863/Association_between_alcohol_consumption_and_the_risk_of_ovarian_cancer:_a_meta_analysis_of_prospective_observational_studies_ L2 - https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-015-1355-8 DB - PRIME DP - Unbound Medicine ER -