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Vitamin D exposure during pregnancy, but not early childhood, is associated with risk of childhood wheezing.
J Dev Orig Health Dis. 2015 Aug; 6(4):308-16.JD

Abstract

The association between vitamin D and wheezing in early childhood is unclear. The primary objective of this study was to evaluate the association between vitamin D exposure, during both pregnancy and childhood, and early childhood wheezing. Secondary objectives were to evaluate the associations between vitamin D exposures and asthma and wheezing severity. We conducted a cohort study of children (0-5 years) recruited from 2008 to 2013 through the TARGet Kids! primary-care research network. Vitamin D exposures included maternal vitamin D supplement use during pregnancy, child vitamin D supplementation and children's 25-hydroxyvitamin D (25(OH)D) concentrations. The outcomes measured were parent-reported childhood wheezing, diagnosed asthma and wheezing severity. Vitamin D supplement and wheezing data were available for 2478 children, and blood samples were available for 1275 children. Adjusted odds ratios (aOR) were estimated using logistic regression adjusted for age, sex, ethnicity, body mass index, birth weight, outdoor play, breastfeeding duration, daycare status, parental smoking and family history of asthma. Vitamin D supplementation during pregnancy was associated with lower odds of childhood wheezing (aOR=0.65; 95% CI: 0.46-0.93). In early childhood, neither 25(OH)D (aOR per 10 nmol/l=1.01; 95% CI: 0.96-1.06) nor vitamin D supplementation (aOR=1.00; 95% CI: 0.81-1.23) was associated with wheezing. No significant associations were observed with diagnosed asthma or wheezing severity. Vitamin D supplementation during pregnancy was associated with reduced odds of wheezing, but child vitamin D supplementation and childhood 25(OH)D were not associated with reduced wheezing. The timing of exposure may be important in understanding the association between vitamin D and childhood wheezing.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Anderson LN
1Division of Pediatric Medicine and the Pediatric Outcomes Research Team,The Hospital for Sick Children,Toronto,Ontario,Canada.
Chen Y
3The Applied Health Research Centre of the Li Ka Shing Knowledge Institute of St. Michael's Hospital,Toronto,Ontario,Canada.
Omand JA
2Department of Pediatrics,St. Michael's Hospital,Toronto,Ontario,Canada.
Birken CS
1Division of Pediatric Medicine and the Pediatric Outcomes Research Team,The Hospital for Sick Children,Toronto,Ontario,Canada.
Parkin PC
1Division of Pediatric Medicine and the Pediatric Outcomes Research Team,The Hospital for Sick Children,Toronto,Ontario,Canada.
To T
1Division of Pediatric Medicine and the Pediatric Outcomes Research Team,The Hospital for Sick Children,Toronto,Ontario,Canada.
Maguire JL
2Department of Pediatrics,St. Michael's Hospital,Toronto,Ontario,Canada.
TARGet Kids Collaboration
No affiliation info available

MeSH

AsthmaChild Nutritional Physiological PhenomenaChild, PreschoolDietary SupplementsFemaleHumansInfantMaleOntarioPregnancyPrenatal Nutritional Physiological PhenomenaProspective StudiesRespiratory SoundsVitamin D

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25885931

Citation

Anderson, L N., et al. "Vitamin D Exposure During Pregnancy, but Not Early Childhood, Is Associated With Risk of Childhood Wheezing." Journal of Developmental Origins of Health and Disease, vol. 6, no. 4, 2015, pp. 308-16.
Anderson LN, Chen Y, Omand JA, et al. Vitamin D exposure during pregnancy, but not early childhood, is associated with risk of childhood wheezing. J Dev Orig Health Dis. 2015;6(4):308-16.
Anderson, L. N., Chen, Y., Omand, J. A., Birken, C. S., Parkin, P. C., To, T., & Maguire, J. L. (2015). Vitamin D exposure during pregnancy, but not early childhood, is associated with risk of childhood wheezing. Journal of Developmental Origins of Health and Disease, 6(4), 308-16. https://doi.org/10.1017/S2040174415001063
Anderson LN, et al. Vitamin D Exposure During Pregnancy, but Not Early Childhood, Is Associated With Risk of Childhood Wheezing. J Dev Orig Health Dis. 2015;6(4):308-16. PubMed PMID: 25885931.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D exposure during pregnancy, but not early childhood, is associated with risk of childhood wheezing. AU - Anderson,L N, AU - Chen,Y, AU - Omand,J A, AU - Birken,C S, AU - Parkin,P C, AU - To,T, AU - Maguire,J L, AU - ,, Y1 - 2015/04/17/ PY - 2015/4/18/entrez PY - 2015/4/18/pubmed PY - 2016/5/10/medline KW - asthma KW - child KW - pre-school KW - vitamin D KW - wheezing SP - 308 EP - 16 JF - Journal of developmental origins of health and disease JO - J Dev Orig Health Dis VL - 6 IS - 4 N2 - The association between vitamin D and wheezing in early childhood is unclear. The primary objective of this study was to evaluate the association between vitamin D exposure, during both pregnancy and childhood, and early childhood wheezing. Secondary objectives were to evaluate the associations between vitamin D exposures and asthma and wheezing severity. We conducted a cohort study of children (0-5 years) recruited from 2008 to 2013 through the TARGet Kids! primary-care research network. Vitamin D exposures included maternal vitamin D supplement use during pregnancy, child vitamin D supplementation and children's 25-hydroxyvitamin D (25(OH)D) concentrations. The outcomes measured were parent-reported childhood wheezing, diagnosed asthma and wheezing severity. Vitamin D supplement and wheezing data were available for 2478 children, and blood samples were available for 1275 children. Adjusted odds ratios (aOR) were estimated using logistic regression adjusted for age, sex, ethnicity, body mass index, birth weight, outdoor play, breastfeeding duration, daycare status, parental smoking and family history of asthma. Vitamin D supplementation during pregnancy was associated with lower odds of childhood wheezing (aOR=0.65; 95% CI: 0.46-0.93). In early childhood, neither 25(OH)D (aOR per 10 nmol/l=1.01; 95% CI: 0.96-1.06) nor vitamin D supplementation (aOR=1.00; 95% CI: 0.81-1.23) was associated with wheezing. No significant associations were observed with diagnosed asthma or wheezing severity. Vitamin D supplementation during pregnancy was associated with reduced odds of wheezing, but child vitamin D supplementation and childhood 25(OH)D were not associated with reduced wheezing. The timing of exposure may be important in understanding the association between vitamin D and childhood wheezing. SN - 2040-1752 UR - https://www.unboundmedicine.com/medline/citation/25885931/Vitamin_D_exposure_during_pregnancy_but_not_early_childhood_is_associated_with_risk_of_childhood_wheezing_ DB - PRIME DP - Unbound Medicine ER -