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Blood profile of oral mucosal disease patients with both vitamin B12 and iron deficiencies.
J Formos Med Assoc. 2015 Jun; 114(6):532-8.JF

Abstract

BACKGROUND/PURPOSE

Vitamin B12 and iron deficiencies lead to macrocytosis [mean corpuscular volume (MCV) ≥ 100 fL] and microcytosis (MCV < 80 fL), respectively. This study evaluated anemic status, MCV, serum homocysteine level, and serum gastric parietal cell antibody (GPCA) level in oral mucosal disease patients with both vitamin B12 and iron deficiencies.

METHODS

The blood hemoglobin (Hb), iron, vitamin B12, folic acid and homocysteine concentrations, MCV, and serum GPCA in 149 patients with both vitamin B12 and iron deficiencies were measured and compared with the corresponding data in 149 age- and sex-matched healthy control subjects.

RESULTS

We found that 54 (36.2%), 16 (10.7%), 44 (29.5%), and 36 (24.2%) patients with both vitamin B12 and iron deficiencies had Hb deficiency (men <13 g/dL, women <12 g/dL), folic acid deficiency (≤ 6 mg/mL), abnormally high blood homocysteine level (>12.6 μM), and serum GPCA positivity, respectively. Patients with both vitamin B12 and iron deficiencies had a significantly higher frequency of Hb deficiency, abnormally elevated blood homocysteine level, and serum GPCA positivity than healthy control subjects (all p values < 0.001). Of 149 patients with both vitamin B12 and iron deficiencies, 10 (6.7%) had high MCV (≥ 100 fL), 108 (72.5%) had normal MCV (between 80 fL and 99 fL), and 31 (20.8%) had low MCV (<80 fL).

CONCLUSION

Approximately 73%, 30%, and 24% of patients with both vitamin B12 and iron deficiencies are found to have normal MCV, abnormally high blood homocysteine level, and serum GPCA positivity, respectively.

Authors+Show Affiliations

Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan.Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address: andysun7702@yahoo.com.tw.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25886860

Citation

Chang, Julia Yu-Fong, et al. "Blood Profile of Oral Mucosal Disease Patients With Both Vitamin B12 and Iron Deficiencies." Journal of the Formosan Medical Association = Taiwan Yi Zhi, vol. 114, no. 6, 2015, pp. 532-8.
Chang JY, Wang YP, Wu YC, et al. Blood profile of oral mucosal disease patients with both vitamin B12 and iron deficiencies. J Formos Med Assoc. 2015;114(6):532-8.
Chang, J. Y., Wang, Y. P., Wu, Y. C., Cheng, S. J., Chen, H. M., & Sun, A. (2015). Blood profile of oral mucosal disease patients with both vitamin B12 and iron deficiencies. Journal of the Formosan Medical Association = Taiwan Yi Zhi, 114(6), 532-8. https://doi.org/10.1016/j.jfma.2015.03.002
Chang JY, et al. Blood Profile of Oral Mucosal Disease Patients With Both Vitamin B12 and Iron Deficiencies. J Formos Med Assoc. 2015;114(6):532-8. PubMed PMID: 25886860.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Blood profile of oral mucosal disease patients with both vitamin B12 and iron deficiencies. AU - Chang,Julia Yu-Fong, AU - Wang,Yi-Ping, AU - Wu,Yang-Che, AU - Cheng,Shih-Jung, AU - Chen,Hsin-Ming, AU - Sun,Andy, Y1 - 2015/04/15/ PY - 2015/02/07/received PY - 2015/03/10/revised PY - 2015/03/17/accepted PY - 2015/4/19/entrez PY - 2015/4/19/pubmed PY - 2016/11/5/medline KW - gastric parietal cell antibody KW - iron deficiency KW - macrocytosis KW - mean corpuscular volume KW - microcytosis KW - vitamin B(12) deficiency SP - 532 EP - 8 JF - Journal of the Formosan Medical Association = Taiwan yi zhi JO - J Formos Med Assoc VL - 114 IS - 6 N2 - BACKGROUND/PURPOSE: Vitamin B12 and iron deficiencies lead to macrocytosis [mean corpuscular volume (MCV) ≥ 100 fL] and microcytosis (MCV < 80 fL), respectively. This study evaluated anemic status, MCV, serum homocysteine level, and serum gastric parietal cell antibody (GPCA) level in oral mucosal disease patients with both vitamin B12 and iron deficiencies. METHODS: The blood hemoglobin (Hb), iron, vitamin B12, folic acid and homocysteine concentrations, MCV, and serum GPCA in 149 patients with both vitamin B12 and iron deficiencies were measured and compared with the corresponding data in 149 age- and sex-matched healthy control subjects. RESULTS: We found that 54 (36.2%), 16 (10.7%), 44 (29.5%), and 36 (24.2%) patients with both vitamin B12 and iron deficiencies had Hb deficiency (men <13 g/dL, women <12 g/dL), folic acid deficiency (≤ 6 mg/mL), abnormally high blood homocysteine level (>12.6 μM), and serum GPCA positivity, respectively. Patients with both vitamin B12 and iron deficiencies had a significantly higher frequency of Hb deficiency, abnormally elevated blood homocysteine level, and serum GPCA positivity than healthy control subjects (all p values < 0.001). Of 149 patients with both vitamin B12 and iron deficiencies, 10 (6.7%) had high MCV (≥ 100 fL), 108 (72.5%) had normal MCV (between 80 fL and 99 fL), and 31 (20.8%) had low MCV (<80 fL). CONCLUSION: Approximately 73%, 30%, and 24% of patients with both vitamin B12 and iron deficiencies are found to have normal MCV, abnormally high blood homocysteine level, and serum GPCA positivity, respectively. SN - 0929-6646 UR - https://www.unboundmedicine.com/medline/citation/25886860/Blood_profile_of_oral_mucosal_disease_patients_with_both_vitamin_B12_and_iron_deficiencies_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0929-6646(15)00130-8 DB - PRIME DP - Unbound Medicine ER -