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Long-term outcomes of granulocyte colony-stimulating factor-combined conditioning in allogeneic hematopoietic stem cell transplantation from HLA-identical family donors for myeloid malignancies.
Leuk Res. 2015 Jun; 39(6):625-31.LR

Abstract

Dormant leukemia cells, which might escape the cytotoxic effect of conditioning before hematopoietic stem cell transplantation (HSCT), could be induced to enter the cell cycle by granulocyte colony-stimulating factor (G-CSF) and become more susceptible to the cell-cycle-specific agent cytarabine arabinoside (Ara-C). Based on this effect, we have utilized G-CSF-combined high-dose Ara-C in myeloablative conditioning for allogeneic bone marrow or peripheral blood stem cell transplantation from HLA-identical family donors since 1988. We report on the long-term outcomes of allogeneic HSCT using a conditioning regimen of 12Gy total body irradiation and G-CSF-combined high-dose Ara-C in 89 adult patients with acute myeloid leukemia, chronic myelogenous leukemia, or myelodysplastic syndrome. With a median follow-up of 135 months, the probability of overall survival and cumulative incidence of relapse at 5 years were 67.8% and 19.4%, respectively. In multivariate analysis, disease status at HSCT was associated with survival and relapse. These data demonstrate that G-CSF-combined myeloablative conditioning could be safely and effectively used for patients with myeloid malignancies.

Authors+Show Affiliations

Department of Hematology/Oncology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan. Electronic address: tkonuma@ims.u-tokyo.ac.jp.Department of Hematology/Oncology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.Department of Hematology/Oncology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.Department of Hematology/Oncology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.System Medical Biology Laboratory, School of Advanced Science and Engineering, Waseda University, Tokyo, Japan.Department of Hematology/Oncology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.Department of Hematology/Oncology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25888304

Citation

Konuma, Takaaki, et al. "Long-term Outcomes of Granulocyte Colony-stimulating Factor-combined Conditioning in Allogeneic Hematopoietic Stem Cell Transplantation From HLA-identical Family Donors for Myeloid Malignancies." Leukemia Research, vol. 39, no. 6, 2015, pp. 625-31.
Konuma T, Kato S, Ishii H, et al. Long-term outcomes of granulocyte colony-stimulating factor-combined conditioning in allogeneic hematopoietic stem cell transplantation from HLA-identical family donors for myeloid malignancies. Leuk Res. 2015;39(6):625-31.
Konuma, T., Kato, S., Ishii, H., Oiwa-Monna, M., Asano, S., Tojo, A., & Takahashi, S. (2015). Long-term outcomes of granulocyte colony-stimulating factor-combined conditioning in allogeneic hematopoietic stem cell transplantation from HLA-identical family donors for myeloid malignancies. Leukemia Research, 39(6), 625-31. https://doi.org/10.1016/j.leukres.2015.03.022
Konuma T, et al. Long-term Outcomes of Granulocyte Colony-stimulating Factor-combined Conditioning in Allogeneic Hematopoietic Stem Cell Transplantation From HLA-identical Family Donors for Myeloid Malignancies. Leuk Res. 2015;39(6):625-31. PubMed PMID: 25888304.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term outcomes of granulocyte colony-stimulating factor-combined conditioning in allogeneic hematopoietic stem cell transplantation from HLA-identical family donors for myeloid malignancies. AU - Konuma,Takaaki, AU - Kato,Seiko, AU - Ishii,Hiroto, AU - Oiwa-Monna,Maki, AU - Asano,Shigetaka, AU - Tojo,Arinobu, AU - Takahashi,Satoshi, Y1 - 2015/04/07/ PY - 2014/10/21/received PY - 2015/01/08/revised PY - 2015/03/19/accepted PY - 2015/4/19/entrez PY - 2015/4/19/pubmed PY - 2015/7/30/medline KW - Allogeneic hematopoietic stem cell transplantation KW - Conditioning regimen KW - Cytarabine arabinoside KW - Granulocyte colony-stimulating factor KW - Myelodysplastic syndrome KW - Myeloid leukemia SP - 625 EP - 31 JF - Leukemia research JO - Leuk Res VL - 39 IS - 6 N2 - Dormant leukemia cells, which might escape the cytotoxic effect of conditioning before hematopoietic stem cell transplantation (HSCT), could be induced to enter the cell cycle by granulocyte colony-stimulating factor (G-CSF) and become more susceptible to the cell-cycle-specific agent cytarabine arabinoside (Ara-C). Based on this effect, we have utilized G-CSF-combined high-dose Ara-C in myeloablative conditioning for allogeneic bone marrow or peripheral blood stem cell transplantation from HLA-identical family donors since 1988. We report on the long-term outcomes of allogeneic HSCT using a conditioning regimen of 12Gy total body irradiation and G-CSF-combined high-dose Ara-C in 89 adult patients with acute myeloid leukemia, chronic myelogenous leukemia, or myelodysplastic syndrome. With a median follow-up of 135 months, the probability of overall survival and cumulative incidence of relapse at 5 years were 67.8% and 19.4%, respectively. In multivariate analysis, disease status at HSCT was associated with survival and relapse. These data demonstrate that G-CSF-combined myeloablative conditioning could be safely and effectively used for patients with myeloid malignancies. SN - 1873-5835 UR - https://www.unboundmedicine.com/medline/citation/25888304/Long_term_outcomes_of_granulocyte_colony_stimulating_factor_combined_conditioning_in_allogeneic_hematopoietic_stem_cell_transplantation_from_HLA_identical_family_donors_for_myeloid_malignancies_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0145-2126(15)00093-4 DB - PRIME DP - Unbound Medicine ER -