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Treatment of alopecia areata with squaric acid dibutylester.
Clin Dermatol. 2015 May-Jun; 33(3):300-4.CD

Abstract

Squaric acid dibutylester is a topical sensitizing agent utilized for the treatment of alopecia areata. The mechanism of action is not fully understood, but is believed to redirect the inflammatory response by invoking allergic contact dermatitis. Several studies have compared the efficacy of squaric acid dibutylester to other treatments vs placebo with favorable results. This contribution reviews the history of the topical sensitizing agent squaric acid dibutylester and discusses the mechanism of action, the use in alopecia areata, and the efficacy and safety of this therapeutic agent.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Hill ND
Department of Dermatology University of Texas at Houston Health Science Center, 6655 Travis Street #600, Houston, TX 77030.
Bunata K
University of Texas at Houston Medical School, 6431 Fannin Street, Houston, TX 77030. Electronic address: Nikki.D.Hill@gmail.com.
Hebert AA
Department of Dermatology University of Texas at Houston Health Science Center, 6655 Travis Street #600, Houston, TX 77030.

MeSH

Adjuvants, ImmunologicAlopecia AreataCyclobutanesHumans

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

25889130

Citation

Hill, Nikki D., et al. "Treatment of Alopecia Areata With Squaric Acid Dibutylester." Clinics in Dermatology, vol. 33, no. 3, 2015, pp. 300-4.
Hill ND, Bunata K, Hebert AA. Treatment of alopecia areata with squaric acid dibutylester. Clin Dermatol. 2015;33(3):300-4.
Hill, N. D., Bunata, K., & Hebert, A. A. (2015). Treatment of alopecia areata with squaric acid dibutylester. Clinics in Dermatology, 33(3), 300-4. https://doi.org/10.1016/j.clindermatol.2014.12.001
Hill ND, Bunata K, Hebert AA. Treatment of Alopecia Areata With Squaric Acid Dibutylester. Clin Dermatol. 2015 May-Jun;33(3):300-4. PubMed PMID: 25889130.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treatment of alopecia areata with squaric acid dibutylester. AU - Hill,Nikki D, AU - Bunata,Kristin, AU - Hebert,Adelaide A, Y1 - 2014/12/08/ PY - 2015/4/19/entrez PY - 2015/4/19/pubmed PY - 2016/1/29/medline SP - 300 EP - 4 JF - Clinics in dermatology JO - Clin Dermatol VL - 33 IS - 3 N2 - Squaric acid dibutylester is a topical sensitizing agent utilized for the treatment of alopecia areata. The mechanism of action is not fully understood, but is believed to redirect the inflammatory response by invoking allergic contact dermatitis. Several studies have compared the efficacy of squaric acid dibutylester to other treatments vs placebo with favorable results. This contribution reviews the history of the topical sensitizing agent squaric acid dibutylester and discusses the mechanism of action, the use in alopecia areata, and the efficacy and safety of this therapeutic agent. SN - 1879-1131 UR - https://www.unboundmedicine.com/medline/citation/25889130/Treatment_of_alopecia_areata_with_squaric_acid_dibutylester_ DB - PRIME DP - Unbound Medicine ER -