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Cruciferous vegetable consumption and the risk of pancreatic cancer: a meta-analysis.

Abstract

BACKGROUND

Previous studies regarding the association between cruciferous vegetable intake and pancreatic cancer risk have reported inconsistent results. We conducted a meta-analysis to demonstrate the potential association between them.

METHODS

A systematic literature search of papers was conducted in March 2014 using PubMed, EMBASE, and Web of Science, and the references of the retrieved articles were screened. The summary odds ratios (ORs) with 95% confidence interval (CI) for the highest versus the lowest intake of cruciferous vegetables were calculated.

RESULTS

Four cohort and five case-control studies were eligible for inclusion. We found a significantly decreased risk of pancreatic cancer associated with the high intake of cruciferous vegetables (OR 0.78, 95% CI 0.64-0.91). Moderate heterogeneity was detected across studies (P = 0.065). There was no evidence of significant publication bias based on Begg's funnel plot (P = 0.917) or Egger's test (P = 0.669).

CONCLUSIONS

Cruciferous vegetable intake might be inversely associated with pancreatic cancer risk. Because of the limited number of studies included in this meta-analysis, further well-designed prospective studies are warranted to confirm the inverse association between cruciferous vegetable intake and risk of pancreatic cancer.

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  • Authors+Show Affiliations

    ,

    Department of General Surgery, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, 325027, China. bassini1113@sina.com.

    ,

    Department of Pediatrics, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China. doctorluoyue@qq.com.

    ,

    Department of General Surgery, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, 325027, China. lumd321@163.com.

    ,

    Department of General Surgery, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, 325027, China. xuxiaow@aliyun.com.

    ,

    Department of General Surgery, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, 325027, China. linhaiduo@qq.com.

    Department of General Surgery, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, 325027, China. surzheng@126.com.

    Source

    MeSH

    Case-Control Studies
    Diet
    Humans
    Pancreatic Neoplasms
    Prognosis
    Risk Factors
    Vegetables

    Pub Type(s)

    Journal Article
    Meta-Analysis

    Language

    eng

    PubMed ID

    25889229

    Citation

    Li, Li-yi, et al. "Cruciferous Vegetable Consumption and the Risk of Pancreatic Cancer: a Meta-analysis." World Journal of Surgical Oncology, vol. 13, 2015, p. 44.
    Li LY, Luo Y, Lu MD, et al. Cruciferous vegetable consumption and the risk of pancreatic cancer: a meta-analysis. World J Surg Oncol. 2015;13:44.
    Li, L. Y., Luo, Y., Lu, M. D., Xu, X. W., Lin, H. D., & Zheng, Z. Q. (2015). Cruciferous vegetable consumption and the risk of pancreatic cancer: a meta-analysis. World Journal of Surgical Oncology, 13, p. 44. doi:10.1186/s12957-015-0454-4.
    Li LY, et al. Cruciferous Vegetable Consumption and the Risk of Pancreatic Cancer: a Meta-analysis. World J Surg Oncol. 2015 Feb 12;13:44. PubMed PMID: 25889229.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Cruciferous vegetable consumption and the risk of pancreatic cancer: a meta-analysis. AU - Li,Li-yi, AU - Luo,Yue, AU - Lu,Ming-dong, AU - Xu,Xiao-wu, AU - Lin,Hai-duo, AU - Zheng,Zhi-qiang, Y1 - 2015/02/12/ PY - 2014/07/19/received PY - 2015/01/08/accepted PY - 2015/4/19/entrez PY - 2015/4/19/pubmed PY - 2016/1/23/medline SP - 44 EP - 44 JF - World journal of surgical oncology JO - World J Surg Oncol VL - 13 N2 - BACKGROUND: Previous studies regarding the association between cruciferous vegetable intake and pancreatic cancer risk have reported inconsistent results. We conducted a meta-analysis to demonstrate the potential association between them. METHODS: A systematic literature search of papers was conducted in March 2014 using PubMed, EMBASE, and Web of Science, and the references of the retrieved articles were screened. The summary odds ratios (ORs) with 95% confidence interval (CI) for the highest versus the lowest intake of cruciferous vegetables were calculated. RESULTS: Four cohort and five case-control studies were eligible for inclusion. We found a significantly decreased risk of pancreatic cancer associated with the high intake of cruciferous vegetables (OR 0.78, 95% CI 0.64-0.91). Moderate heterogeneity was detected across studies (P = 0.065). There was no evidence of significant publication bias based on Begg's funnel plot (P = 0.917) or Egger's test (P = 0.669). CONCLUSIONS: Cruciferous vegetable intake might be inversely associated with pancreatic cancer risk. Because of the limited number of studies included in this meta-analysis, further well-designed prospective studies are warranted to confirm the inverse association between cruciferous vegetable intake and risk of pancreatic cancer. SN - 1477-7819 UR - https://www.unboundmedicine.com/medline/citation/25889229/full_citation L2 - https://wjso.biomedcentral.com/articles/10.1186/s12957-015-0454-4 DB - PRIME DP - Unbound Medicine ER -