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Elevated Serum Gamma-glutamyl Transpeptidase Levels and Fatty Liver Strongly Predict the Presence of Carotid Plaque.
J Atheroscler Thromb 2015; 22(10):1051-60JA

Abstract

AIM

There is a strong relationship between carotid atherosclerosis and future cardiovascular disease (CVD). This study sought to clarify the association of fatty liver and an elevated serum gamma-glutamyl transpeptidase (GGT) level with carotid atherosclerosis.

METHODS

We reviewed the medical records of subjects who underwent medical checkups at our institute. Carotid atherosclerosis and fatty liver were assessed using ultrasound (US), and predictors of increased carotid intima-media thickness (IMT) and carotid plaque were identified using a logistic regression model.

RESULTS

In total, 958 subjects (564 men, 394 women; median age, 59 years) were enrolled. The median value of the mean carotid IMT was 0.713 mm, and the frequency of carotid plaque was 19.5%. For the highest quartile of the mean carotid IMT (≥ 0.863 mm), a male sex, older age, hypertension (HT), dyslipidemia (DL) and type 2 diabetes mellitus (DM) were identified as independent predictors. A male sex, older age, HT and elevated serum GGT level were found to be significant predictors of the presence of carotid plaque. In addition, fatty liver correlated with the existence of carotid plaque. When the combination of the serum GGT level and presence or absence of fatty liver was included as a variable in the analysis, a male sex, older age, HT and fatty liver with a serum GGT level of ≥ 83 IU/L (90th percentile) (odds ratio 3.21, 95% confidence interval 1.27-8.12, p=0.014)were identified to be significantly associated with carotid plaque.

CONCLUSIONS

This study suggests that the simultaneous presence of an elevated serum GGT level and fatty liver is highly predictive of carotid plaque.

Authors+Show Affiliations

Department of Hepatology, Kanazawa Medical University.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25891209

Citation

Toshikuni, Nobuyuki, et al. "Elevated Serum Gamma-glutamyl Transpeptidase Levels and Fatty Liver Strongly Predict the Presence of Carotid Plaque." Journal of Atherosclerosis and Thrombosis, vol. 22, no. 10, 2015, pp. 1051-60.
Toshikuni N, Asaji T, Nakanishi Y, et al. Elevated Serum Gamma-glutamyl Transpeptidase Levels and Fatty Liver Strongly Predict the Presence of Carotid Plaque. J Atheroscler Thromb. 2015;22(10):1051-60.
Toshikuni, N., Asaji, T., Nakanishi, Y., Nagasawa, S. Y., Uenishi, H., & Tsutsumi, M. (2015). Elevated Serum Gamma-glutamyl Transpeptidase Levels and Fatty Liver Strongly Predict the Presence of Carotid Plaque. Journal of Atherosclerosis and Thrombosis, 22(10), pp. 1051-60. doi:10.5551/jat.28274.
Toshikuni N, et al. Elevated Serum Gamma-glutamyl Transpeptidase Levels and Fatty Liver Strongly Predict the Presence of Carotid Plaque. J Atheroscler Thromb. 2015;22(10):1051-60. PubMed PMID: 25891209.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Elevated Serum Gamma-glutamyl Transpeptidase Levels and Fatty Liver Strongly Predict the Presence of Carotid Plaque. AU - Toshikuni,Nobuyuki, AU - Asaji,Takayoshi, AU - Nakanishi,Yumiko, AU - Nagasawa,Shin-ya, AU - Uenishi,Hiroaki, AU - Tsutsumi,Mikihiro, Y1 - 2015/04/20/ PY - 2015/4/21/entrez PY - 2015/4/22/pubmed PY - 2016/8/17/medline SP - 1051 EP - 60 JF - Journal of atherosclerosis and thrombosis JO - J. Atheroscler. Thromb. VL - 22 IS - 10 N2 - AIM: There is a strong relationship between carotid atherosclerosis and future cardiovascular disease (CVD). This study sought to clarify the association of fatty liver and an elevated serum gamma-glutamyl transpeptidase (GGT) level with carotid atherosclerosis. METHODS: We reviewed the medical records of subjects who underwent medical checkups at our institute. Carotid atherosclerosis and fatty liver were assessed using ultrasound (US), and predictors of increased carotid intima-media thickness (IMT) and carotid plaque were identified using a logistic regression model. RESULTS: In total, 958 subjects (564 men, 394 women; median age, 59 years) were enrolled. The median value of the mean carotid IMT was 0.713 mm, and the frequency of carotid plaque was 19.5%. For the highest quartile of the mean carotid IMT (≥ 0.863 mm), a male sex, older age, hypertension (HT), dyslipidemia (DL) and type 2 diabetes mellitus (DM) were identified as independent predictors. A male sex, older age, HT and elevated serum GGT level were found to be significant predictors of the presence of carotid plaque. In addition, fatty liver correlated with the existence of carotid plaque. When the combination of the serum GGT level and presence or absence of fatty liver was included as a variable in the analysis, a male sex, older age, HT and fatty liver with a serum GGT level of ≥ 83 IU/L (90th percentile) (odds ratio 3.21, 95% confidence interval 1.27-8.12, p=0.014)were identified to be significantly associated with carotid plaque. CONCLUSIONS: This study suggests that the simultaneous presence of an elevated serum GGT level and fatty liver is highly predictive of carotid plaque. SN - 1880-3873 UR - https://www.unboundmedicine.com/medline/citation/25891209/Elevated_Serum_Gamma_glutamyl_Transpeptidase_Levels_and_Fatty_Liver_Strongly_Predict_the_Presence_of_Carotid_Plaque_ L2 - https://dx.doi.org/10.5551/jat.28274 DB - PRIME DP - Unbound Medicine ER -