Tags

Type your tag names separated by a space and hit enter

Drug loading optimization and extended drug delivery of corticoids from pHEMA based soft contact lenses hydrogels via chemical and microstructural modifications.
Int J Pharm. 2015 Jun 20; 487(1-2):260-9.IJ

Abstract

This paper proposes an approach to improve drug loading capacity and release properties of poly(2-hydroxyethyl methacrylate) (p(HEMA)) soft contact lenses based on the optimization of the hydrogel composition and microstructural modifications using water during the polymerization process. P(HEMA) based soft contact lenses were prepared by thermal or photopolymerization of 2-hydroxyethyl methacrylate (HEMA) solutions containing ethylene glycol di-methacrylate as crosslinker and different proportions of N-vinyl-2-pyrrolidone (NVP) or methacrylic acid (MA) as co-monomers. Transmittance, water uptake, swelling, microstructure, drug absorption isotherms and in vitro release were characterized using triamcinolone acetonide (TA) as model drug. Best drug loading ratios were obtained with lenses containing the highest amount (200 mM) of MA. Incorporation of 40% V/V of water during the polymerization increases the hydrogel porosity giving a better drug loading capacity. In vitro TA release kinetics shows that MA hydrogels released the drug significantly faster than NVP-hydrogels. Drug release was found to be diffusion controlled and kinetics was shown to be reproducible after consecutive drug loading/release processes. Results of p(HEMA) based soft contact lenses copolymerized with ethylene glycol dimethacrylate (EGDMA) and different co-monomers could be a good alternative to optimize the loading and ocular drug delivery of this corticosteroid drug.

Authors+Show Affiliations

Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Santiago de Compostela, Campus Vida s/n, 15782 Santiago de Compostela, Spain.Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Santiago de Compostela, Campus Vida s/n, 15782 Santiago de Compostela, Spain.Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Santiago de Compostela, Campus Vida s/n, 15782 Santiago de Compostela, Spain; Instituto de Farmacia Industrial, Facultad de Farmacia, Universidad de Santiago de Compostela, Campus Vida s/n, 15782 Santiago de Compostela, Spain. Electronic address: francisco.otero@usc.es.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25891253

Citation

García-Millán, Eva, et al. "Drug Loading Optimization and Extended Drug Delivery of Corticoids From pHEMA Based Soft Contact Lenses Hydrogels Via Chemical and Microstructural Modifications." International Journal of Pharmaceutics, vol. 487, no. 1-2, 2015, pp. 260-9.
García-Millán E, Koprivnik S, Otero-Espinar FJ. Drug loading optimization and extended drug delivery of corticoids from pHEMA based soft contact lenses hydrogels via chemical and microstructural modifications. Int J Pharm. 2015;487(1-2):260-9.
García-Millán, E., Koprivnik, S., & Otero-Espinar, F. J. (2015). Drug loading optimization and extended drug delivery of corticoids from pHEMA based soft contact lenses hydrogels via chemical and microstructural modifications. International Journal of Pharmaceutics, 487(1-2), 260-9. https://doi.org/10.1016/j.ijpharm.2015.04.037
García-Millán E, Koprivnik S, Otero-Espinar FJ. Drug Loading Optimization and Extended Drug Delivery of Corticoids From pHEMA Based Soft Contact Lenses Hydrogels Via Chemical and Microstructural Modifications. Int J Pharm. 2015 Jun 20;487(1-2):260-9. PubMed PMID: 25891253.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Drug loading optimization and extended drug delivery of corticoids from pHEMA based soft contact lenses hydrogels via chemical and microstructural modifications. AU - García-Millán,Eva, AU - Koprivnik,Sandra, AU - Otero-Espinar,Francisco Javier, Y1 - 2015/04/17/ PY - 2015/03/18/received PY - 2015/04/11/revised PY - 2015/04/15/accepted PY - 2015/4/21/entrez PY - 2015/4/22/pubmed PY - 2016/2/18/medline KW - Controlled drug release/delivery KW - Hydrogels KW - Microstructure KW - Ophthalmic drug delivery KW - Poly(2-hydroxyethyl methacrylate) KW - Therapeutic soft contact lenses KW - Triamcinolone acetonide SP - 260 EP - 9 JF - International journal of pharmaceutics JO - Int J Pharm VL - 487 IS - 1-2 N2 - This paper proposes an approach to improve drug loading capacity and release properties of poly(2-hydroxyethyl methacrylate) (p(HEMA)) soft contact lenses based on the optimization of the hydrogel composition and microstructural modifications using water during the polymerization process. P(HEMA) based soft contact lenses were prepared by thermal or photopolymerization of 2-hydroxyethyl methacrylate (HEMA) solutions containing ethylene glycol di-methacrylate as crosslinker and different proportions of N-vinyl-2-pyrrolidone (NVP) or methacrylic acid (MA) as co-monomers. Transmittance, water uptake, swelling, microstructure, drug absorption isotherms and in vitro release were characterized using triamcinolone acetonide (TA) as model drug. Best drug loading ratios were obtained with lenses containing the highest amount (200 mM) of MA. Incorporation of 40% V/V of water during the polymerization increases the hydrogel porosity giving a better drug loading capacity. In vitro TA release kinetics shows that MA hydrogels released the drug significantly faster than NVP-hydrogels. Drug release was found to be diffusion controlled and kinetics was shown to be reproducible after consecutive drug loading/release processes. Results of p(HEMA) based soft contact lenses copolymerized with ethylene glycol dimethacrylate (EGDMA) and different co-monomers could be a good alternative to optimize the loading and ocular drug delivery of this corticosteroid drug. SN - 1873-3476 UR - https://www.unboundmedicine.com/medline/citation/25891253/Drug_loading_optimization_and_extended_drug_delivery_of_corticoids_from_pHEMA_based_soft_contact_lenses_hydrogels_via_chemical_and_microstructural_modifications_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5173(15)00345-2 DB - PRIME DP - Unbound Medicine ER -