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Oxidative and nitrosative stress in ADHD: possible causes and the potential of antioxidant-targeted therapies.

Abstract

Attention deficit hyperactivity disorder (ADHD) has a complex aetiology although theories associated with disturbances in dopaminergic and noradrenergic activity are most commonly cited. The importance of these catecholamines in ADHD is supported by its effective treatment utilising stimulant and non-stimulant medications that modify their activity. Recently, there has been interest in oxidative and nitrosative stress (O&NS) in ADHD and its potential to contribute to this condition. In this article, research investigating O&NS in ADHD is reviewed and its impact on catecholaminergic activity and neurological structure is discussed. Lifestyle, environmental, psychological and nutritional influences on O&NS in people with ADHD are reviewed, and evidence for the therapeutic efficacy of antioxidant-related therapies is assessed. A selection of interventions with antioxidant mechanisms is presented as potential options for the treatment of ADHD. However, further research is required to help elucidate the role of O&NS and antioxidants for the prevention and management of ADHD.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    School of Psychology and Exercise Science, Murdoch University, Perth, WA, 6150, Australia. a.lopresti@murdoch.edu.au. , 4/165 Summerlakes Pde, Ballajura, WA, 6066, Australia. a.lopresti@murdoch.edu.au.

    Source

    MeSH

    Antioxidants
    Attention Deficit Disorder with Hyperactivity
    Humans
    Nitrosation
    Oxidation-Reduction
    Oxidative Stress

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    25894292

    Citation

    Lopresti, Adrian L.. "Oxidative and Nitrosative Stress in ADHD: Possible Causes and the Potential of Antioxidant-targeted Therapies." Attention Deficit and Hyperactivity Disorders, vol. 7, no. 4, 2015, pp. 237-47.
    Lopresti AL. Oxidative and nitrosative stress in ADHD: possible causes and the potential of antioxidant-targeted therapies. Atten Defic Hyperact Disord. 2015;7(4):237-47.
    Lopresti, A. L. (2015). Oxidative and nitrosative stress in ADHD: possible causes and the potential of antioxidant-targeted therapies. Attention Deficit and Hyperactivity Disorders, 7(4), pp. 237-47. doi:10.1007/s12402-015-0170-5.
    Lopresti AL. Oxidative and Nitrosative Stress in ADHD: Possible Causes and the Potential of Antioxidant-targeted Therapies. Atten Defic Hyperact Disord. 2015;7(4):237-47. PubMed PMID: 25894292.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Oxidative and nitrosative stress in ADHD: possible causes and the potential of antioxidant-targeted therapies. A1 - Lopresti,Adrian L, Y1 - 2015/04/19/ PY - 2014/12/17/received PY - 2015/04/07/accepted PY - 2015/4/21/entrez PY - 2015/4/22/pubmed PY - 2016/9/1/medline KW - ADHD KW - Antioxidant KW - Free radical KW - Oxidative stress KW - Treatment SP - 237 EP - 47 JF - Attention deficit and hyperactivity disorders JO - Atten Defic Hyperact Disord VL - 7 IS - 4 N2 - Attention deficit hyperactivity disorder (ADHD) has a complex aetiology although theories associated with disturbances in dopaminergic and noradrenergic activity are most commonly cited. The importance of these catecholamines in ADHD is supported by its effective treatment utilising stimulant and non-stimulant medications that modify their activity. Recently, there has been interest in oxidative and nitrosative stress (O&NS) in ADHD and its potential to contribute to this condition. In this article, research investigating O&NS in ADHD is reviewed and its impact on catecholaminergic activity and neurological structure is discussed. Lifestyle, environmental, psychological and nutritional influences on O&NS in people with ADHD are reviewed, and evidence for the therapeutic efficacy of antioxidant-related therapies is assessed. A selection of interventions with antioxidant mechanisms is presented as potential options for the treatment of ADHD. However, further research is required to help elucidate the role of O&NS and antioxidants for the prevention and management of ADHD. SN - 1866-6647 UR - https://www.unboundmedicine.com/medline/citation/25894292/Oxidative_and_nitrosative_stress_in_ADHD:_possible_causes_and_the_potential_of_antioxidant_targeted_therapies_ L2 - https://dx.doi.org/10.1007/s12402-015-0170-5 DB - PRIME DP - Unbound Medicine ER -