Citation
Dobre, Mirela, et al. "Persistent High Serum Bicarbonate and the Risk of Heart Failure in Patients With Chronic Kidney Disease (CKD): a Report From the Chronic Renal Insufficiency Cohort (CRIC) Study." Journal of the American Heart Association, vol. 4, no. 4, 2015.
Dobre M, Yang W, Pan Q, et al. Persistent high serum bicarbonate and the risk of heart failure in patients with chronic kidney disease (CKD): A report from the Chronic Renal Insufficiency Cohort (CRIC) study. J Am Heart Assoc. 2015;4(4).
Dobre, M., Yang, W., Pan, Q., Appel, L., Bellovich, K., Chen, J., Feldman, H., Fischer, M. J., Ham, L. L., Hostetter, T., Jaar, B. G., Kallem, R. R., Rosas, S. E., Scialla, J. J., Wolf, M., & Rahman, M. (2015). Persistent high serum bicarbonate and the risk of heart failure in patients with chronic kidney disease (CKD): A report from the Chronic Renal Insufficiency Cohort (CRIC) study. Journal of the American Heart Association, 4(4). https://doi.org/10.1161/JAHA.114.001599
Dobre M, et al. Persistent High Serum Bicarbonate and the Risk of Heart Failure in Patients With Chronic Kidney Disease (CKD): a Report From the Chronic Renal Insufficiency Cohort (CRIC) Study. J Am Heart Assoc. 2015 Apr 20;4(4) PubMed PMID: 25896890.
TY - JOUR
T1 - Persistent high serum bicarbonate and the risk of heart failure in patients with chronic kidney disease (CKD): A report from the Chronic Renal Insufficiency Cohort (CRIC) study.
AU - Dobre,Mirela,
AU - Yang,Wei,
AU - Pan,Qiang,
AU - Appel,Lawrence,
AU - Bellovich,Keith,
AU - Chen,Jing,
AU - Feldman,Harold,
AU - Fischer,Michael J,
AU - Ham,L L,
AU - Hostetter,Thomas,
AU - Jaar,Bernard G,
AU - Kallem,Radhakrishna R,
AU - Rosas,Sylvia E,
AU - Scialla,Julia J,
AU - Wolf,Myles,
AU - Rahman,Mahboob,
AU - ,,
Y1 - 2015/04/20/
PY - 2015/4/22/entrez
PY - 2015/4/22/pubmed
PY - 2016/4/20/medline
KW - CKD
KW - heart failure
KW - serum bicarbonate
JF - Journal of the American Heart Association
JO - J Am Heart Assoc
VL - 4
IS - 4
N2 - BACKGROUND: Serum bicarbonate varies over time in chronic kidney disease (CKD) patients, and this variability may portend poor cardiovascular outcomes. The aim of this study was to conduct a time-updated longitudinal analysis to evaluate the association of serum bicarbonate with long-term clinical outcomes: heart failure, atherosclerotic events, renal events (halving of estimated glomerular filtration rate [eGFR] or end-stage renal disease), and mortality. METHODS AND RESULTS: Serum bicarbonate was measured annually, in 3586 participants with CKD, enrolled in the Chronic Renal Insufficiency Cohort (CRIC) study. Marginal structural models were created to allow for integration of all available bicarbonate measurements and proper adjustment for time-dependent confounding. During the 6 years follow-up, 512 participants developed congestive heart failure (26/1000 person-years) and 749 developed renal events (37/1000 person-years). The risk of heart failure and death was significantly higher for participants who maintained serum bicarbonate >26 mmol/L for the entire duration of follow-up (hazard ratio [HR] 1.66; 95% confidence interval [CI], 1.23 to 2.23, and HR 1.36, 95% CI 1.02 to 1.82, respectively) compared with participants who kept their bicarbonate 22 to 26 mmol/L, after adjusting for demographics, co-morbidities, medications including diuretics, eGFR, and proteinuria. Participants who maintained serum bicarbonate <22 mmol/L had almost a 2-fold increased risk of renal disease progression (HR 1.97; 95% CI, 1.50 to 2.57) compared with participants with bicarbonate 22 to 26 mmol/L. CONCLUSION: In this large CKD cohort, persistent serum bicarbonate >26 mmol/L was associated with increased risk of heart failure events and mortality. Further studies are needed to determine the optimal range of serum bicarbonate in CKD to prevent adverse clinical outcomes.
SN - 2047-9980
UR - https://www.unboundmedicine.com/medline/citation/25896890/Persistent_high_serum_bicarbonate_and_the_risk_of_heart_failure_in_patients_with_chronic_kidney_disease__CKD_:_A_report_from_the_Chronic_Renal_Insufficiency_Cohort__CRIC__study_
L2 - https://www.ahajournals.org/doi/10.1161/JAHA.114.001599?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed
DB - PRIME
DP - Unbound Medicine
ER -