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Chikungunya virus pathogenesis and immunity.
Vector Borne Zoonotic Dis. 2015 Apr; 15(4):241-9.VB

Abstract

Chikungunya virus (CHIKV) is an arbovirus associated with acute and chronic arthralgia that re-emerged in the Indian Ocean islands in 2005-2006 and is currently responsible for the ongoing outbreaks in the Caribbean islands and the Americas. We describe here the acute and chronic clinical manifestations of CHIKV in patients that define the disease. We also review the various animal models that have been developed to study CHIKV infection and pathology and further strengthened the understanding of the cellular and molecular mechanisms of CHIKV infection and immunity. A complete understanding of the immunopathogenesis of CHIKV infection will help develop the needed preventive and therapeutic approaches to combat this arbovirosis.

Authors+Show Affiliations

1 University of La Reunion , GRI/IRG EA4517, and Centre Hospitalier Universitaire (CHU North Felix-Guyon), Saint-Denis, La Reunion, France .No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

25897810

Citation

Gasque, Philippe, et al. "Chikungunya Virus Pathogenesis and Immunity." Vector Borne and Zoonotic Diseases (Larchmont, N.Y.), vol. 15, no. 4, 2015, pp. 241-9.
Gasque P, Couderc T, Lecuit M, et al. Chikungunya virus pathogenesis and immunity. Vector Borne Zoonotic Dis. 2015;15(4):241-9.
Gasque, P., Couderc, T., Lecuit, M., Roques, P., & Ng, L. F. (2015). Chikungunya virus pathogenesis and immunity. Vector Borne and Zoonotic Diseases (Larchmont, N.Y.), 15(4), 241-9. https://doi.org/10.1089/vbz.2014.1710
Gasque P, et al. Chikungunya Virus Pathogenesis and Immunity. Vector Borne Zoonotic Dis. 2015;15(4):241-9. PubMed PMID: 25897810.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chikungunya virus pathogenesis and immunity. AU - Gasque,Philippe, AU - Couderc,Therese, AU - Lecuit,Marc, AU - Roques,Pierre, AU - Ng,Lisa F P, PY - 2015/4/22/entrez PY - 2015/4/22/pubmed PY - 2016/5/3/medline KW - Adaptive immunity KW - Chikungunya KW - Cytokines and chemokines KW - Inflammation KW - Innate immunity KW - Target cells SP - 241 EP - 9 JF - Vector borne and zoonotic diseases (Larchmont, N.Y.) JO - Vector Borne Zoonotic Dis VL - 15 IS - 4 N2 - Chikungunya virus (CHIKV) is an arbovirus associated with acute and chronic arthralgia that re-emerged in the Indian Ocean islands in 2005-2006 and is currently responsible for the ongoing outbreaks in the Caribbean islands and the Americas. We describe here the acute and chronic clinical manifestations of CHIKV in patients that define the disease. We also review the various animal models that have been developed to study CHIKV infection and pathology and further strengthened the understanding of the cellular and molecular mechanisms of CHIKV infection and immunity. A complete understanding of the immunopathogenesis of CHIKV infection will help develop the needed preventive and therapeutic approaches to combat this arbovirosis. SN - 1557-7759 UR - https://www.unboundmedicine.com/medline/citation/25897810/Chikungunya_virus_pathogenesis_and_immunity_ L2 - https://www.liebertpub.com/doi/10.1089/vbz.2014.1710?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -