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A comparison of the dose-response relationship for psoralen-UVA erythema and UVB erythema.
Arch Dermatol. 1989 Dec; 125(12):1653-7.AD

Abstract

Twenty patients with psoriasis were phototested to determine their erythemal responses to UVB and psoralen-UVA (PUVA) (oral 8-methoxypsoralen). The smallest ultraviolet radiation doses to produce erythema (minimal erythema dose and minimal phototoxic dose, respectively) were recorded and dose-response curves were constructed for UVB (24 hours after irradiation) and PUVA (48 hours) using objective measurement. The choice of a 48-hour measurement was validated by phototesting an additional 11 subjects to determine the time course of PUVA erythema. No correlation was demonstrated between minimal erythema dose for UVB, minimal phototoxic dose for PUVA, and sun-reactive skin type. The mean slope of the dose-response curve for UVB erythema was four times steeper than that for PUVA. Psoralen-UVA erythema reached a broad maximum between 48 and 96 hours after irradiation. Using objective methods we have demonstrated that the commonly accepted view of a steep dose-response relationship for PUVA erythema is not valid.

Authors+Show Affiliations

Department of Dermatology, Royal Victoria Infirmary, Newcastle-upon-Tyne, England.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

2589859

Citation

Cox, N H., et al. "A Comparison of the Dose-response Relationship for psoralen-UVA Erythema and UVB Erythema." Archives of Dermatology, vol. 125, no. 12, 1989, pp. 1653-7.
Cox NH, Farr PM, Diffey BL. A comparison of the dose-response relationship for psoralen-UVA erythema and UVB erythema. Arch Dermatol. 1989;125(12):1653-7.
Cox, N. H., Farr, P. M., & Diffey, B. L. (1989). A comparison of the dose-response relationship for psoralen-UVA erythema and UVB erythema. Archives of Dermatology, 125(12), 1653-7.
Cox NH, Farr PM, Diffey BL. A Comparison of the Dose-response Relationship for psoralen-UVA Erythema and UVB Erythema. Arch Dermatol. 1989;125(12):1653-7. PubMed PMID: 2589859.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A comparison of the dose-response relationship for psoralen-UVA erythema and UVB erythema. AU - Cox,N H, AU - Farr,P M, AU - Diffey,B L, PY - 1989/12/1/pubmed PY - 1989/12/1/medline PY - 1989/12/1/entrez SP - 1653 EP - 7 JF - Archives of dermatology JO - Arch Dermatol VL - 125 IS - 12 N2 - Twenty patients with psoriasis were phototested to determine their erythemal responses to UVB and psoralen-UVA (PUVA) (oral 8-methoxypsoralen). The smallest ultraviolet radiation doses to produce erythema (minimal erythema dose and minimal phototoxic dose, respectively) were recorded and dose-response curves were constructed for UVB (24 hours after irradiation) and PUVA (48 hours) using objective measurement. The choice of a 48-hour measurement was validated by phototesting an additional 11 subjects to determine the time course of PUVA erythema. No correlation was demonstrated between minimal erythema dose for UVB, minimal phototoxic dose for PUVA, and sun-reactive skin type. The mean slope of the dose-response curve for UVB erythema was four times steeper than that for PUVA. Psoralen-UVA erythema reached a broad maximum between 48 and 96 hours after irradiation. Using objective methods we have demonstrated that the commonly accepted view of a steep dose-response relationship for PUVA erythema is not valid. SN - 0003-987X UR - https://www.unboundmedicine.com/medline/citation/2589859/A_comparison_of_the_dose_response_relationship_for_psoralen_UVA_erythema_and_UVB_erythema_ L2 - https://jamanetwork.com/journals/jamadermatology/fullarticle/vol/125/pg/1653 DB - PRIME DP - Unbound Medicine ER -