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A review of biomarkers for predicting clinical reactivity to foods with a focus on specific immunoglobulin E antibodies.
Curr Opin Allergy Clin Immunol 2015; 15(3):250-8CO

Abstract

PURPOSE OF REVIEW

The purpose of this study is to assess the latest studies that focus on specific immunoglobulin (Ig)E antibodies for predicting clinical reactivity to foods.

RECENT FINDINGS

Persistent hen's egg and cow's milk allergy patients have higher antigen-specific IgE levels at all ages than those who have outgrown these allergies. Recent studies on the natural histories of hen's egg and cow's milk allergies suggested that baseline antigen-specific IgEs are the most important predictors of tolerance. Oral immunotherapy (OIT), which is a novel therapeutic approach for food allergy, requires biomarkers for predicting outcomes after therapy. Several studies indicate that the initial antigen-specific IgE level may be a useful biomarker for the prognosis of OIT. Recently, component-resolved diagnostics (CRD) has been used for food allergy diagnosis. Current studies have suggested that Ara h 2, omega-5 gliadin and ovomucoid are good diagnostic markers for peanut, wheat and egg allergies, respectively.

SUMMARY

Antigen-specific IgE can be a useful biomarker for predicting clinical reactivity to food allergies. Monitoring hen's egg and cow's milk-specific IgE is useful for predicting prognosis, and baseline specific IgE levels may be associated with the outcome of OIT. The use of CRD provides us with a better tool for diagnosing food allergy.

Authors+Show Affiliations

aDepartment of Allergy, Clinical Research Center for Allergology and Rheumatology bDepartment of Pediatrics, Sagamihara National Hospital, Kanagawa, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

25899696

Citation

Sato, Sakura, et al. "A Review of Biomarkers for Predicting Clinical Reactivity to Foods With a Focus On Specific Immunoglobulin E Antibodies." Current Opinion in Allergy and Clinical Immunology, vol. 15, no. 3, 2015, pp. 250-8.
Sato S, Yanagida N, Ohtani K, et al. A review of biomarkers for predicting clinical reactivity to foods with a focus on specific immunoglobulin E antibodies. Curr Opin Allergy Clin Immunol. 2015;15(3):250-8.
Sato, S., Yanagida, N., Ohtani, K., Koike, Y., & Ebisawa, M. (2015). A review of biomarkers for predicting clinical reactivity to foods with a focus on specific immunoglobulin E antibodies. Current Opinion in Allergy and Clinical Immunology, 15(3), pp. 250-8. doi:10.1097/ACI.0000000000000162.
Sato S, et al. A Review of Biomarkers for Predicting Clinical Reactivity to Foods With a Focus On Specific Immunoglobulin E Antibodies. Curr Opin Allergy Clin Immunol. 2015;15(3):250-8. PubMed PMID: 25899696.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A review of biomarkers for predicting clinical reactivity to foods with a focus on specific immunoglobulin E antibodies. AU - Sato,Sakura, AU - Yanagida,Noriyuki, AU - Ohtani,Kiyotaka, AU - Koike,Yumi, AU - Ebisawa,Motohiro, PY - 2015/4/23/entrez PY - 2015/4/23/pubmed PY - 2016/4/2/medline SP - 250 EP - 8 JF - Current opinion in allergy and clinical immunology JO - Curr Opin Allergy Clin Immunol VL - 15 IS - 3 N2 - PURPOSE OF REVIEW: The purpose of this study is to assess the latest studies that focus on specific immunoglobulin (Ig)E antibodies for predicting clinical reactivity to foods. RECENT FINDINGS: Persistent hen's egg and cow's milk allergy patients have higher antigen-specific IgE levels at all ages than those who have outgrown these allergies. Recent studies on the natural histories of hen's egg and cow's milk allergies suggested that baseline antigen-specific IgEs are the most important predictors of tolerance. Oral immunotherapy (OIT), which is a novel therapeutic approach for food allergy, requires biomarkers for predicting outcomes after therapy. Several studies indicate that the initial antigen-specific IgE level may be a useful biomarker for the prognosis of OIT. Recently, component-resolved diagnostics (CRD) has been used for food allergy diagnosis. Current studies have suggested that Ara h 2, omega-5 gliadin and ovomucoid are good diagnostic markers for peanut, wheat and egg allergies, respectively. SUMMARY: Antigen-specific IgE can be a useful biomarker for predicting clinical reactivity to food allergies. Monitoring hen's egg and cow's milk-specific IgE is useful for predicting prognosis, and baseline specific IgE levels may be associated with the outcome of OIT. The use of CRD provides us with a better tool for diagnosing food allergy. SN - 1473-6322 UR - https://www.unboundmedicine.com/medline/citation/25899696/A_review_of_biomarkers_for_predicting_clinical_reactivity_to_foods_with_a_focus_on_specific_immunoglobulin_E_antibodies_ L2 - http://Insights.ovid.com/pubmed?pmid=25899696 DB - PRIME DP - Unbound Medicine ER -