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β-Adrenoceptor blockade modulates fusiform gyrus activity to black versus white faces.
Psychopharmacology (Berl) 2015; 232(16):2951-8P

Abstract

INTRODUCTION

The beta-adrenoceptor antagonist propranolol is known to reduce peripheral and central activity of noradrenaline. A recent study found that intervention with propranolol diminished negative implicit racial bias.

MATERIALS AND METHOD

The current study used functional magnetic resonance imaging (fMRI) in order to determine the neural correlates of this effect. Healthy volunteers (N = 40) of white ethnic origin received a single oral dose (40 mg) of propranolol, in a randomised, double-blind, parallel group, placebo-controlled design, before viewing unfamiliar faces of same and other race.

RESULTS AND DISCUSSION

We found significantly reduced activity in the fusiform gyrus and thalamus following propranolol to out-group faces only. Additionally, propranolol lowered the implicit attitude score, without affecting explicit prejudice measure.

CONCLUSION

These findings suggest that noradrenaline pathways might modulate racial bias by acting on the processing of categorisation in the fusiform gyrus.

Authors+Show Affiliations

Department of Psychology, University of Plymouth, Drake Circus, Plymouth, PL48AA, UK, sylvia.terbeck@psy.ox.ac.uk.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25899791

Citation

Terbeck, S, et al. "Β-Adrenoceptor Blockade Modulates Fusiform Gyrus Activity to Black Versus White Faces." Psychopharmacology, vol. 232, no. 16, 2015, pp. 2951-8.
Terbeck S, Kahane G, McTavish S, et al. Β-Adrenoceptor blockade modulates fusiform gyrus activity to black versus white faces. Psychopharmacology (Berl). 2015;232(16):2951-8.
Terbeck, S., Kahane, G., McTavish, S., McCutcheon, R., Hewstone, M., Savulescu, J., ... Norbury, R. (2015). Β-Adrenoceptor blockade modulates fusiform gyrus activity to black versus white faces. Psychopharmacology, 232(16), pp. 2951-8. doi:10.1007/s00213-015-3929-7.
Terbeck S, et al. Β-Adrenoceptor Blockade Modulates Fusiform Gyrus Activity to Black Versus White Faces. Psychopharmacology (Berl). 2015;232(16):2951-8. PubMed PMID: 25899791.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - β-Adrenoceptor blockade modulates fusiform gyrus activity to black versus white faces. AU - Terbeck,S, AU - Kahane,G, AU - McTavish,S, AU - McCutcheon,R, AU - Hewstone,M, AU - Savulescu,J, AU - Chesterman,L P, AU - Cowen,P J, AU - Norbury,R, Y1 - 2015/04/22/ PY - 2014/12/19/received PY - 2015/03/30/accepted PY - 2015/4/23/entrez PY - 2015/4/23/pubmed PY - 2016/2/26/medline SP - 2951 EP - 8 JF - Psychopharmacology JO - Psychopharmacology (Berl.) VL - 232 IS - 16 N2 - INTRODUCTION: The beta-adrenoceptor antagonist propranolol is known to reduce peripheral and central activity of noradrenaline. A recent study found that intervention with propranolol diminished negative implicit racial bias. MATERIALS AND METHOD: The current study used functional magnetic resonance imaging (fMRI) in order to determine the neural correlates of this effect. Healthy volunteers (N = 40) of white ethnic origin received a single oral dose (40 mg) of propranolol, in a randomised, double-blind, parallel group, placebo-controlled design, before viewing unfamiliar faces of same and other race. RESULTS AND DISCUSSION: We found significantly reduced activity in the fusiform gyrus and thalamus following propranolol to out-group faces only. Additionally, propranolol lowered the implicit attitude score, without affecting explicit prejudice measure. CONCLUSION: These findings suggest that noradrenaline pathways might modulate racial bias by acting on the processing of categorisation in the fusiform gyrus. SN - 1432-2072 UR - https://www.unboundmedicine.com/medline/citation/25899791/β_Adrenoceptor_blockade_modulates_fusiform_gyrus_activity_to_black_versus_white_faces_ L2 - https://dx.doi.org/10.1007/s00213-015-3929-7 DB - PRIME DP - Unbound Medicine ER -