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Pharmaceutical spray freeze drying.
Int J Pharm. 2015 Jul 05; 488(1-2):136-53.IJ

Abstract

Pharmaceutical spray-freeze drying (SFD) includes a heterogeneous set of technologies with primary applications in apparent solubility enhancement, pulmonary drug delivery, intradermal ballistic administration and delivery of vaccines to the nasal mucosa. The methods comprise of three steps: droplet generation, freezing and sublimation drying, which can be matched to the requirements given by the dosage form and route of administration. The objectives, various methods and physicochemical and pharmacological outcomes have been reviewed with a scope including related fields of science and technology.

Authors+Show Affiliations

Laboratory of Pharmaceutical Technology and Biopharmaceutics, Institute of Pharmacy, University of Bonn, Bonn, Germany.Laboratory of Pharmaceutical Technology and Biopharmaceutics, Institute of Pharmacy, University of Bonn, Bonn, Germany.Laboratory of Pharmaceutical Technology and Biopharmaceutics, Institute of Pharmacy, University of Bonn, Bonn, Germany; Laboratory of Pharmaceutical Engineering (EA4267), University of Franche-Comté, Besançon, France. Electronic address: alf.lamprecht@uni-bonn.de.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

25900097

Citation

Wanning, Stefan, et al. "Pharmaceutical Spray Freeze Drying." International Journal of Pharmaceutics, vol. 488, no. 1-2, 2015, pp. 136-53.
Wanning S, Süverkrüp R, Lamprecht A. Pharmaceutical spray freeze drying. Int J Pharm. 2015;488(1-2):136-53.
Wanning, S., Süverkrüp, R., & Lamprecht, A. (2015). Pharmaceutical spray freeze drying. International Journal of Pharmaceutics, 488(1-2), 136-53. https://doi.org/10.1016/j.ijpharm.2015.04.053
Wanning S, Süverkrüp R, Lamprecht A. Pharmaceutical Spray Freeze Drying. Int J Pharm. 2015 Jul 5;488(1-2):136-53. PubMed PMID: 25900097.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pharmaceutical spray freeze drying. AU - Wanning,Stefan, AU - Süverkrüp,Richard, AU - Lamprecht,Alf, Y1 - 2015/04/18/ PY - 2014/12/23/received PY - 2015/04/15/revised PY - 2015/04/16/accepted PY - 2015/4/23/entrez PY - 2015/4/23/pubmed PY - 2016/2/4/medline KW - Lyophilisation KW - Porous particles KW - Protein formulations KW - Pulmonary application KW - Spray freeze drying KW - Vaccination SP - 136 EP - 53 JF - International journal of pharmaceutics JO - Int J Pharm VL - 488 IS - 1-2 N2 - Pharmaceutical spray-freeze drying (SFD) includes a heterogeneous set of technologies with primary applications in apparent solubility enhancement, pulmonary drug delivery, intradermal ballistic administration and delivery of vaccines to the nasal mucosa. The methods comprise of three steps: droplet generation, freezing and sublimation drying, which can be matched to the requirements given by the dosage form and route of administration. The objectives, various methods and physicochemical and pharmacological outcomes have been reviewed with a scope including related fields of science and technology. SN - 1873-3476 UR - https://www.unboundmedicine.com/medline/citation/25900097/Pharmaceutical_spray_freeze_drying_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5173(15)00361-0 DB - PRIME DP - Unbound Medicine ER -