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Serum prolidase levels in Graves' disease without ophthalmopathy and its association with oxidative status.
J Endocrinol Invest 2015; 38(11):1167-73JE

Abstract

OBJECTIVE

The aim of this study was to evaluate serum prolidase levels and its association with oxidative stress in autoimmune thyroid disease (AITD).

MATERIALS AND METHODS

25 with Hashimoto thyroiditis (HT) and 25 patients Graves' disease (GD), and 27 healthy controls were enrolled in the study. The patients with signs of Graves' ophthalmopathy were excluded from the study. Serum samples were obtained in euthyroid period at the third month of treatment. Serum prolidase, total antioxidant status (TAS), total oxidative stress (TOS), and total free sulfhydryl (-SH) levels were measured.

RESULTS

Serum prolidase levels were significantly higher in the patients with GD compared to the HT and the healthy control group. Oxidative stress index (OSI) and TOS levels of the patients with both GD and HT were significantly higher compared to those of the control group (p < 0.001, for each), while -SH levels were significantly lower (p < 0.001, for each). There was no significant difference between the patients with HT and healthy control group in terms of prolidase levels (p = 0.580). Prolidase levels were positively correlated with TOS and OSI and negatively correlated with -SH (r = 0.565, p = 0.003; r = 0.604, p = 0.001; r = -0.532, p = 0.006).

CONCLUSION

Serum prolidase activity is increased in GD patients without signs of ophthalmopathy, and showed a positive correlation with oxidative stress parameters.

Authors+Show Affiliations

Division of Endocrinology, Department of Internal Medicine, Faculty of Medicine, Gaziantep University, 27100, Sahinbey, Gaziantep, Turkey. drhkorkmaz@yahoo.com.tr.Division of Endocrinology, Department of Internal Medicine, Faculty of Medicine, Gaziantep University, 27100, Sahinbey, Gaziantep, Turkey.Division of Endocrinology, Department of Internal Medicine, Faculty of Medicine, Gaziantep University, 27100, Sahinbey, Gaziantep, Turkey.Department of Medical Pharmacology, Faculty of Medicine, Harran University, 63300, Sanliurfa, Turkey.Department of Clinical Biochemistry, Faculty of Medicine, Harran University, 63300, Sanliurfa, Turkey.Division of Endocrinology, Department of Internal Medicine, Faculty of Medicine, Gaziantep University, 27100, Sahinbey, Gaziantep, Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25900177

Citation

Korkmaz, H, et al. "Serum Prolidase Levels in Graves' Disease Without Ophthalmopathy and Its Association With Oxidative Status." Journal of Endocrinological Investigation, vol. 38, no. 11, 2015, pp. 1167-73.
Korkmaz H, Tabur S, Ozkaya M, et al. Serum prolidase levels in Graves' disease without ophthalmopathy and its association with oxidative status. J Endocrinol Invest. 2015;38(11):1167-73.
Korkmaz, H., Tabur, S., Ozkaya, M., Oguz, E., Aksoy, N., & Akarsu, E. (2015). Serum prolidase levels in Graves' disease without ophthalmopathy and its association with oxidative status. Journal of Endocrinological Investigation, 38(11), pp. 1167-73. doi:10.1007/s40618-015-0278-7.
Korkmaz H, et al. Serum Prolidase Levels in Graves' Disease Without Ophthalmopathy and Its Association With Oxidative Status. J Endocrinol Invest. 2015;38(11):1167-73. PubMed PMID: 25900177.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum prolidase levels in Graves' disease without ophthalmopathy and its association with oxidative status. AU - Korkmaz,H, AU - Tabur,S, AU - Ozkaya,M, AU - Oguz,E, AU - Aksoy,N, AU - Akarsu,E, Y1 - 2015/04/22/ PY - 2015/01/27/received PY - 2015/03/17/accepted PY - 2015/4/23/entrez PY - 2015/4/23/pubmed PY - 2016/7/21/medline KW - Graves’ disease KW - Hashimoto’s thyroiditis KW - Oxidative status KW - Prolidase SP - 1167 EP - 73 JF - Journal of endocrinological investigation JO - J. Endocrinol. Invest. VL - 38 IS - 11 N2 - OBJECTIVE: The aim of this study was to evaluate serum prolidase levels and its association with oxidative stress in autoimmune thyroid disease (AITD). MATERIALS AND METHODS: 25 with Hashimoto thyroiditis (HT) and 25 patients Graves' disease (GD), and 27 healthy controls were enrolled in the study. The patients with signs of Graves' ophthalmopathy were excluded from the study. Serum samples were obtained in euthyroid period at the third month of treatment. Serum prolidase, total antioxidant status (TAS), total oxidative stress (TOS), and total free sulfhydryl (-SH) levels were measured. RESULTS: Serum prolidase levels were significantly higher in the patients with GD compared to the HT and the healthy control group. Oxidative stress index (OSI) and TOS levels of the patients with both GD and HT were significantly higher compared to those of the control group (p < 0.001, for each), while -SH levels were significantly lower (p < 0.001, for each). There was no significant difference between the patients with HT and healthy control group in terms of prolidase levels (p = 0.580). Prolidase levels were positively correlated with TOS and OSI and negatively correlated with -SH (r = 0.565, p = 0.003; r = 0.604, p = 0.001; r = -0.532, p = 0.006). CONCLUSION: Serum prolidase activity is increased in GD patients without signs of ophthalmopathy, and showed a positive correlation with oxidative stress parameters. SN - 1720-8386 UR - https://www.unboundmedicine.com/medline/citation/25900177/Serum_prolidase_levels_in_Graves'_disease_without_ophthalmopathy_and_its_association_with_oxidative_status_ L2 - https://link.springer.com/article/10.1007/s40618-015-0278-7 DB - PRIME DP - Unbound Medicine ER -