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Effects of Equisetum arvense Ointment on Dermal Wound Healing in Rats .
Wounds 2010; 22(10):261-7W

Abstract

The aim of this study was to evaluate the effectiveness of Equisetum arvense ointment on dermal wound healing in rats.

METHODS

The authors studied a total of 56 wounds in four groups of rats. Each wound measured 15 mm x 15 mm. The first group did not receive treatment while the second group was treated with a 1:1 mixture of Vaseline and lanolin ointment. Equisetum arvense ointment doses of 5% and 10% were used in the third and fourth groups. The rats were observed at days 7 and 14 post wounding. The state of the wound healing was evaluated using wound closure ratio and histopathologic studies.

RESULTS

Equisetum arvense 5% and 10% groups and the Vaseline-lanolin group had a statistically significant higher wound closure ratio than the control group (P &0.05). Equisetum arvense ointment groups had a 95.26% and 99.96% wound closure ratio (P & 0.05) and higher dermal and epidermal regeneration, angiogenesis, and granulation tissue thickness after 14 days as compared to the other groups (P & 0.05). P. Equisetum arvense ointment exhibits significant wound healing activity in rats. Further clinical and experimental studies are needed to confirm these results. .

Authors+Show Affiliations

No affiliation info availableNo affiliation info availableSaglik Yuksekokulu FTR Bolumu, Merkez Kampus, Kutahya, Turkey; Email: alicimbiz@yahoo.com.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25901493

Citation

Ozay, Yusuf, et al. "Effects of Equisetum Arvense Ointment On Dermal Wound Healing in Rats ." Wounds : a Compendium of Clinical Research and Practice, vol. 22, no. 10, 2010, pp. 261-7.
Ozay Y, Ozyurt S, Guzel S, et al. Effects of Equisetum arvense Ointment on Dermal Wound Healing in Rats . Wounds. 2010;22(10):261-7.
Ozay, Y., Ozyurt, S., Guzel, S., Cimbiz, A., Olgun, E. G., & Cayci, M. K. (2010). Effects of Equisetum arvense Ointment on Dermal Wound Healing in Rats . Wounds : a Compendium of Clinical Research and Practice, 22(10), pp. 261-7.
Ozay Y, et al. Effects of Equisetum Arvense Ointment On Dermal Wound Healing in Rats . Wounds. 2010;22(10):261-7. PubMed PMID: 25901493.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of Equisetum arvense Ointment on Dermal Wound Healing in Rats . AU - Ozay,Yusuf, AU - Ozyurt,Sabri, AU - Guzel,Sevda, AU - Cimbiz,Ali, AU - Olgun,Esra G, AU - Cayci,M Kasim, PY - 2015/4/23/entrez PY - 2010/10/1/pubmed PY - 2010/10/1/medline SP - 261 EP - 7 JF - Wounds : a compendium of clinical research and practice JO - Wounds VL - 22 IS - 10 N2 - UNLABELLED: The aim of this study was to evaluate the effectiveness of Equisetum arvense ointment on dermal wound healing in rats. METHODS: The authors studied a total of 56 wounds in four groups of rats. Each wound measured 15 mm x 15 mm. The first group did not receive treatment while the second group was treated with a 1:1 mixture of Vaseline and lanolin ointment. Equisetum arvense ointment doses of 5% and 10% were used in the third and fourth groups. The rats were observed at days 7 and 14 post wounding. The state of the wound healing was evaluated using wound closure ratio and histopathologic studies. RESULTS: Equisetum arvense 5% and 10% groups and the Vaseline-lanolin group had a statistically significant higher wound closure ratio than the control group (P &0.05). Equisetum arvense ointment groups had a 95.26% and 99.96% wound closure ratio (P & 0.05) and higher dermal and epidermal regeneration, angiogenesis, and granulation tissue thickness after 14 days as compared to the other groups (P & 0.05). P. Equisetum arvense ointment exhibits significant wound healing activity in rats. Further clinical and experimental studies are needed to confirm these results. . SN - 1044-7946 UR - https://www.unboundmedicine.com/medline/citation/25901493/Effects_of_Equisetum_arvense_Ointment_on_Dermal_Wound_Healing_in_Rats__ DB - PRIME DP - Unbound Medicine ER -