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Association between monovalent influenza A (H1N1) pdm09 vaccine and pneumonia among the elderly in the 2009-2010 season in Japan: A case-control study.

Abstract

We investigated the association between monovalent influenza A (H1N1) pdm09 (H1N1pdm) vaccine and pneumonia in elderly people. Study design was a hospital-based, matched case-control study. Cases comprised patients ≥ 65 years old who had been newly diagnosed with pneumonia. For each case, 2 controls were defined as individuals with other diseases (not pneumonia) who were matched by sex, age, entry date, and the visited hospital. Study period was the interval from 1 September 2009 until 30 September 2010. Because a pandemic of influenza A (H1N1) occurred during study period, we analyzed selected subjects who had enrolled during the influenza A (H1N1) pandemic. We calculated the odds ratios (ORs) and 95% confidence intervals (CIs) for pneumonia in H1N1pdm-vaccinated subjects compared with unvaccinated subjects using a conditional logistic regression model to assess the association between H1N1pdm vaccine and pneumonia. The subjects during the period of the influenza A (H1N1) pandemic were 20 cases and 40 controls. Subjects who had received H1N1pdm vaccine showed a significantly decreased OR for pneumonia (OR = 0.10, 95% CI = 0.01-0.98) compared with unvaccinated subjects. In conclusion, H1N1pdm vaccination may have prevented pneumonia among the elderly during the 2009-2010 influenza A (H1N1) pandemic in Japan.

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  • Authors+Show Affiliations

    ,

    a Department of Public Health; Faculty of Medicine; Osaka City University ; Osaka , Japan.

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    Source

    MeSH

    Aged
    Aged, 80 and over
    Case-Control Studies
    Female
    Humans
    Influenza A Virus, H1N1 Subtype
    Influenza Vaccines
    Influenza, Human
    Japan
    Male
    Pneumonia

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    25901995

    Citation

    Kondo, Kyoko, et al. "Association Between Monovalent Influenza a (H1N1) Pdm09 Vaccine and Pneumonia Among the Elderly in the 2009-2010 Season in Japan: a Case-control Study." Human Vaccines & Immunotherapeutics, vol. 11, no. 5, 2015, pp. 1088-93.
    Kondo K, Suzuki K, Washio M, et al. Association between monovalent influenza A (H1N1) pdm09 vaccine and pneumonia among the elderly in the 2009-2010 season in Japan: A case-control study. Hum Vaccin Immunother. 2015;11(5):1088-93.
    Kondo, K., Suzuki, K., Washio, M., Ohfuji, S., Fukushima, W., Maeda, A., & Hirota, Y. (2015). Association between monovalent influenza A (H1N1) pdm09 vaccine and pneumonia among the elderly in the 2009-2010 season in Japan: A case-control study. Human Vaccines & Immunotherapeutics, 11(5), pp. 1088-93. doi:10.1080/21645515.2015.1016668.
    Kondo K, et al. Association Between Monovalent Influenza a (H1N1) Pdm09 Vaccine and Pneumonia Among the Elderly in the 2009-2010 Season in Japan: a Case-control Study. Hum Vaccin Immunother. 2015;11(5):1088-93. PubMed PMID: 25901995.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Association between monovalent influenza A (H1N1) pdm09 vaccine and pneumonia among the elderly in the 2009-2010 season in Japan: A case-control study. AU - Kondo,Kyoko, AU - Suzuki,Kanzo, AU - Washio,Masakazu, AU - Ohfuji,Satoko, AU - Fukushima,Wakaba, AU - Maeda,Akiko, AU - Hirota,Yoshio, AU - ,, PY - 2015/4/23/entrez PY - 2015/4/23/pubmed PY - 2016/2/26/medline KW - ADL, activities of daily living KW - CI, confidence interval KW - COPD, chronic obstructive pulmonary disease KW - H1N1pdm, monovalent influenza A (H1N1) pdm09 KW - OR, odds ratio KW - TIV, trivalent seasonal influenza vaccine KW - effectiveness KW - elderly people KW - matched case-control study KW - monovalent influenza A (H1N1) pdm09 vaccine KW - pneumonia SP - 1088 EP - 93 JF - Human vaccines & immunotherapeutics JO - Hum Vaccin Immunother VL - 11 IS - 5 N2 - We investigated the association between monovalent influenza A (H1N1) pdm09 (H1N1pdm) vaccine and pneumonia in elderly people. Study design was a hospital-based, matched case-control study. Cases comprised patients ≥ 65 years old who had been newly diagnosed with pneumonia. For each case, 2 controls were defined as individuals with other diseases (not pneumonia) who were matched by sex, age, entry date, and the visited hospital. Study period was the interval from 1 September 2009 until 30 September 2010. Because a pandemic of influenza A (H1N1) occurred during study period, we analyzed selected subjects who had enrolled during the influenza A (H1N1) pandemic. We calculated the odds ratios (ORs) and 95% confidence intervals (CIs) for pneumonia in H1N1pdm-vaccinated subjects compared with unvaccinated subjects using a conditional logistic regression model to assess the association between H1N1pdm vaccine and pneumonia. The subjects during the period of the influenza A (H1N1) pandemic were 20 cases and 40 controls. Subjects who had received H1N1pdm vaccine showed a significantly decreased OR for pneumonia (OR = 0.10, 95% CI = 0.01-0.98) compared with unvaccinated subjects. In conclusion, H1N1pdm vaccination may have prevented pneumonia among the elderly during the 2009-2010 influenza A (H1N1) pandemic in Japan. SN - 2164-554X UR - https://www.unboundmedicine.com/medline/citation/25901995/Association_between_monovalent_influenza_A__H1N1__pdm09_vaccine_and_pneumonia_among_the_elderly_in_the_2009_2010_season_in_Japan:_A_case_control_study_ L2 - http://www.tandfonline.com/doi/full/10.1080/21645515.2015.1016668 DB - PRIME DP - Unbound Medicine ER -