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Effect of oxpentifylline on blood viscosity and cerebral blood flow in man.
Br J Clin Pharmacol. 1989 Oct; 28(4):488-92.BJ

Abstract

The effects of intravenous oxpentifylline on blood viscosity and cerebral blood flow were studied in eight patients with cerebrovascular disease using a double-blind placebo controlled design. A single dose of 200 mg oxpentifylline in 10 ml saline was given by intravenous injection over 10 min and compared with 10 ml saline alone. Whole blood and plasma viscosity were measured in a Contraves LS 30 coaxial viscometer at shear rates of 0.7 and 94.5 s-1. Cerebral blood flow was measured by the non-invasive intravenous xenon133 clearance method. The measurements were made before and then 30 min after the start of the injection of drug or saline alone. Oxpentifylline was found to have no significant effect on blood viscosity or cerebral blood flow.

Authors+Show Affiliations

Department of Neurology, London Hospital.

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2590608

Citation

Brown, M M.. "Effect of Oxpentifylline On Blood Viscosity and Cerebral Blood Flow in Man." British Journal of Clinical Pharmacology, vol. 28, no. 4, 1989, pp. 488-92.
Brown MM. Effect of oxpentifylline on blood viscosity and cerebral blood flow in man. Br J Clin Pharmacol. 1989;28(4):488-92.
Brown, M. M. (1989). Effect of oxpentifylline on blood viscosity and cerebral blood flow in man. British Journal of Clinical Pharmacology, 28(4), 488-92.
Brown MM. Effect of Oxpentifylline On Blood Viscosity and Cerebral Blood Flow in Man. Br J Clin Pharmacol. 1989;28(4):488-92. PubMed PMID: 2590608.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of oxpentifylline on blood viscosity and cerebral blood flow in man. A1 - Brown,M M, PY - 1989/10/1/pubmed PY - 1989/10/1/medline PY - 1989/10/1/entrez SP - 488 EP - 92 JF - British journal of clinical pharmacology JO - Br J Clin Pharmacol VL - 28 IS - 4 N2 - The effects of intravenous oxpentifylline on blood viscosity and cerebral blood flow were studied in eight patients with cerebrovascular disease using a double-blind placebo controlled design. A single dose of 200 mg oxpentifylline in 10 ml saline was given by intravenous injection over 10 min and compared with 10 ml saline alone. Whole blood and plasma viscosity were measured in a Contraves LS 30 coaxial viscometer at shear rates of 0.7 and 94.5 s-1. Cerebral blood flow was measured by the non-invasive intravenous xenon133 clearance method. The measurements were made before and then 30 min after the start of the injection of drug or saline alone. Oxpentifylline was found to have no significant effect on blood viscosity or cerebral blood flow. SN - 0306-5251 UR - https://www.unboundmedicine.com/medline/citation/2590608/Effect_of_oxpentifylline_on_blood_viscosity_and_cerebral_blood_flow_in_man_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0306-5251&date=1989&volume=28&issue=4&spage=488 DB - PRIME DP - Unbound Medicine ER -