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The role of multicomponent therapy in the metabolic syndrome, inflammation and cardiovascular risk in obese adolescents.
Br J Nutr. 2015 Jun 28; 113(12):1920-30.BJ

Abstract

Obesity is characterised by low-grade inflammation, which increases the metabolic syndrome (MetS) and cardiovascular risks. The aim of the present study was to verify the role of multicomponent therapy in controlling the MetS, inflammation and carotid intima-media thickness (cIMT) in obese adolescents. The second aim was to investigate the relationships between adipokines, the MetS parameters and cIMT. A total of sixty-nine obese adolescents participated in the present study and completed 1 year of multicomponent therapy (a combination of strategies involving nutrition, psychology, physical exercise and clinical therapy), and were divided according to their MetS diagnosis as follows: MetS (n 19); non-MetS (n 50). Blood analyses of glucose, lipid and adipokine concentrations (adiponectin, leptin, plasminogen activator inhibitor 1 (PAI-1) and C-reactive protein) were collected. Insulin resistance was assessed using the homeostasis model assessment for insulin resistance, quantitative insulin sensitivity check index and homeostasis model assessment-adiponectin. cIMT and visceral and subcutaneous fat were estimated using ultrasonography. At baseline, the MetS group presented higher waist circumference, glucose and insulin levels, and systolic and median blood pressures compared with the non-MetS group. After therapy, both groups showed improvements in the anthropometric profile, body composition, insulin level, insulin resistance, insulin sensibility, TAG and VLDL-cholesterol, adiponectin, leptin and PAI-1 levels, blood pressure and cIMT. The prevalence of the MetS was reduced from 27·5 to 13·0 %. Metabolic syndrome patients showed resistance in the attenuation of total cholesterol and LDL-cholesterol (LDL-C) levels and leptin:adiponectin and adiponectin:leptin ratios. In the MetS group, the variation in the adiponectin:leptin ratio was correlated with variations in glucose, insulin sensibility, total cholesterol, LDL-c and systolic blood pressure. Additionally, the number of MetS parameters was correlated with the carotid measurement. Moreover, the variation in cIMT was correlated with the variations in insulin sensibility, total cholesterol and LDL-c. For the entire group, the number of MetS alterations was correlated with the leptin level and leptin:adiponectin ratio and adiponectin:leptin ratio after therapy. In conclusion, multicomponent therapy was effective in controlling the MetS, inflammation and cIMT in the obese adolescents. However, the MetS patients showed resistance in the attenuation of the atherogenic lipid profile and leptin:adiponectin ratio and adiponectin:leptin ratio. These results suggest that the MetS patients have increased cardiovascular risks, and that it is important to attempt to control the inflammatory process that occurs due to obesity in clinical practice in order to improve the health of adolescents.

Authors+Show Affiliations

Post-Graduate Program of Nutrition, Universidade Federal de São Paulo,São Paulo-SP,Brasil.Post-Graduate Program of Nutrition, Universidade Federal de São Paulo,São Paulo-SP,Brasil.Post-Graduate Program of Nutrition, Universidade Federal de São Paulo,São Paulo-SP,Brasil.Post-Graduate Program of Nutrition, Universidade Federal de São Paulo,São Paulo-SP,Brasil.Post-Graduate Program of Nutrition, Universidade Federal de São Paulo,São Paulo-SP,Brasil.Post-Graduate Program of Nutrition, Universidade Federal de São Paulo,São Paulo-SP,Brasil.Post-Graduate Program of Nutrition, Universidade Federal de São Paulo,São Paulo-SP,Brasil.Post-Graduate Program of Interdisciplinary Health Science, Universidade Federal de São Paulo,Santos-SP,Brasil.Post-Graduate Program of Nutrition, Universidade Federal de São Paulo,São Paulo-SP,Brasil.Post-Graduate Program of Nutrition, Universidade Federal de São Paulo,São Paulo-SP,Brasil.Post-Graduate Program of Nutrition, Universidade Federal de São Paulo,São Paulo-SP,Brasil.Department of Psycobiology,Universidade Federal de São Paulo,São Paulo-SP,Brasil.Post-Graduate Program of Nutrition, Universidade Federal de São Paulo,São Paulo-SP,Brasil.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25907896

Citation

Masquio, Deborah C L., et al. "The Role of Multicomponent Therapy in the Metabolic Syndrome, Inflammation and Cardiovascular Risk in Obese Adolescents." The British Journal of Nutrition, vol. 113, no. 12, 2015, pp. 1920-30.
Masquio DC, de Piano A, Campos RM, et al. The role of multicomponent therapy in the metabolic syndrome, inflammation and cardiovascular risk in obese adolescents. Br J Nutr. 2015;113(12):1920-30.
Masquio, D. C., de Piano, A., Campos, R. M., Sanches, P. L., Carnier, J., Corgosinho, F. C., Netto, B. D., Carvalho-Ferreira, J. P., Oyama, L. M., Nascimento, C. M., de Mello, M. T., Tufik, S., & Dâmaso, A. R. (2015). The role of multicomponent therapy in the metabolic syndrome, inflammation and cardiovascular risk in obese adolescents. The British Journal of Nutrition, 113(12), 1920-30. https://doi.org/10.1017/S0007114515001129
Masquio DC, et al. The Role of Multicomponent Therapy in the Metabolic Syndrome, Inflammation and Cardiovascular Risk in Obese Adolescents. Br J Nutr. 2015 Jun 28;113(12):1920-30. PubMed PMID: 25907896.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of multicomponent therapy in the metabolic syndrome, inflammation and cardiovascular risk in obese adolescents. AU - Masquio,Deborah C L, AU - de Piano,Aline, AU - Campos,Raquel M S, AU - Sanches,Priscila L, AU - Carnier,June, AU - Corgosinho,Flávia C, AU - Netto,Bárbara D M, AU - Carvalho-Ferreira,Joana P, AU - Oyama,Lila M, AU - Nascimento,Claudia M O, AU - de Mello,Marco T, AU - Tufik,Sergio, AU - Dâmaso,Ana R, Y1 - 2015/04/24/ PY - 2015/4/25/entrez PY - 2015/4/25/pubmed PY - 2015/9/22/medline KW - Adiponectin KW - Carotid intima-media thickness KW - Inflammation KW - Leptin KW - Metabolic syndrome KW - Obesity SP - 1920 EP - 30 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 113 IS - 12 N2 - Obesity is characterised by low-grade inflammation, which increases the metabolic syndrome (MetS) and cardiovascular risks. The aim of the present study was to verify the role of multicomponent therapy in controlling the MetS, inflammation and carotid intima-media thickness (cIMT) in obese adolescents. The second aim was to investigate the relationships between adipokines, the MetS parameters and cIMT. A total of sixty-nine obese adolescents participated in the present study and completed 1 year of multicomponent therapy (a combination of strategies involving nutrition, psychology, physical exercise and clinical therapy), and were divided according to their MetS diagnosis as follows: MetS (n 19); non-MetS (n 50). Blood analyses of glucose, lipid and adipokine concentrations (adiponectin, leptin, plasminogen activator inhibitor 1 (PAI-1) and C-reactive protein) were collected. Insulin resistance was assessed using the homeostasis model assessment for insulin resistance, quantitative insulin sensitivity check index and homeostasis model assessment-adiponectin. cIMT and visceral and subcutaneous fat were estimated using ultrasonography. At baseline, the MetS group presented higher waist circumference, glucose and insulin levels, and systolic and median blood pressures compared with the non-MetS group. After therapy, both groups showed improvements in the anthropometric profile, body composition, insulin level, insulin resistance, insulin sensibility, TAG and VLDL-cholesterol, adiponectin, leptin and PAI-1 levels, blood pressure and cIMT. The prevalence of the MetS was reduced from 27·5 to 13·0 %. Metabolic syndrome patients showed resistance in the attenuation of total cholesterol and LDL-cholesterol (LDL-C) levels and leptin:adiponectin and adiponectin:leptin ratios. In the MetS group, the variation in the adiponectin:leptin ratio was correlated with variations in glucose, insulin sensibility, total cholesterol, LDL-c and systolic blood pressure. Additionally, the number of MetS parameters was correlated with the carotid measurement. Moreover, the variation in cIMT was correlated with the variations in insulin sensibility, total cholesterol and LDL-c. For the entire group, the number of MetS alterations was correlated with the leptin level and leptin:adiponectin ratio and adiponectin:leptin ratio after therapy. In conclusion, multicomponent therapy was effective in controlling the MetS, inflammation and cIMT in the obese adolescents. However, the MetS patients showed resistance in the attenuation of the atherogenic lipid profile and leptin:adiponectin ratio and adiponectin:leptin ratio. These results suggest that the MetS patients have increased cardiovascular risks, and that it is important to attempt to control the inflammatory process that occurs due to obesity in clinical practice in order to improve the health of adolescents. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/25907896/The_role_of_multicomponent_therapy_in_the_metabolic_syndrome_inflammation_and_cardiovascular_risk_in_obese_adolescents_ L2 - https://www.cambridge.org/core/product/identifier/S0007114515001129/type/journal_article DB - PRIME DP - Unbound Medicine ER -