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Parecoxib for the prevention of shivering after general anesthesia.
J Surg Res. 2015 Jul; 197(1):139-44.JS

Abstract

BACKGROUND

Shivering is the most common complication during the recovery period after general anesthesia, and there is no clear consensus about the best strategy for its prophylactic. The aim of the study was to evaluate the efficacy of parecoxib in prevention of postoperative shivering.

METHODS

Eighty patients with American Society of Anesthesiologists physical status I-II, who were scheduled for minor urological surgeries under general anesthesia, were randomly assigned to two groups (n = 40 in each group): group P received 40 mg of parecoxib by intravenous bolus injection and group S received the same volume of normal saline in the same way just after the induction of anesthesia. Hemodynamic parameters and body temperatures including tympanic and axillary temperature were monitored. The occurrence of shivering and pain intensity score were recorded during the recovery period.

RESULTS

Parecoxib significantly reduced the incidence and severity of shivering in comparison with the placebo. Postoperative shivering was observed in 22 patients in group S (55%), compared with nine in group P (22.5%) (P = 0.003). In addition, pain intensity scores were lower in group P during recovery period; consequently, less rescue analgesics were required in group P when compared with group S (P = 0.001). Regarding the body temperature, it was found that core temperature decreased but peripheral temperature increased significantly in both groups. There was no significant difference between groups in all time intervals.

CONCLUSIONS

Prophylactic administration of parecoxib produces dual effects on antishivering and postoperative analgesia. This implies that cyclooxygenase 2-prostaglandin E2 pathways may be involved in the regulation of shivering.

Authors+Show Affiliations

Department of Radiology, Chongqing Fifth Hospital, Chongqing, PR China.Department of Anaesthesiology, Southwest Hospital, Third Military Medical University, Chongqing, PR China.Department of Anaesthesiology, Southwest Hospital, Third Military Medical University, Chongqing, PR China.Department of Anaesthesiology, Southwest Hospital, Third Military Medical University, Chongqing, PR China. Electronic address: cjandsh@tmmu.edu.cn.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

25908099

Citation

Shen, Hong, et al. "Parecoxib for the Prevention of Shivering After General Anesthesia." The Journal of Surgical Research, vol. 197, no. 1, 2015, pp. 139-44.
Shen H, Chen Y, Lu KZ, et al. Parecoxib for the prevention of shivering after general anesthesia. J Surg Res. 2015;197(1):139-44.
Shen, H., Chen, Y., Lu, K. Z., & Chen, J. (2015). Parecoxib for the prevention of shivering after general anesthesia. The Journal of Surgical Research, 197(1), 139-44. https://doi.org/10.1016/j.jss.2015.03.011
Shen H, et al. Parecoxib for the Prevention of Shivering After General Anesthesia. J Surg Res. 2015;197(1):139-44. PubMed PMID: 25908099.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Parecoxib for the prevention of shivering after general anesthesia. AU - Shen,Hong, AU - Chen,Yan, AU - Lu,Kai-zhi, AU - Chen,Jie, Y1 - 2015/03/28/ PY - 2014/04/29/received PY - 2015/01/26/revised PY - 2015/03/10/accepted PY - 2015/4/25/entrez PY - 2015/4/25/pubmed PY - 2015/8/19/medline KW - General anesthesia KW - Parecoxib KW - Postoperative shivering SP - 139 EP - 44 JF - The Journal of surgical research JO - J. Surg. Res. VL - 197 IS - 1 N2 - BACKGROUND: Shivering is the most common complication during the recovery period after general anesthesia, and there is no clear consensus about the best strategy for its prophylactic. The aim of the study was to evaluate the efficacy of parecoxib in prevention of postoperative shivering. METHODS: Eighty patients with American Society of Anesthesiologists physical status I-II, who were scheduled for minor urological surgeries under general anesthesia, were randomly assigned to two groups (n = 40 in each group): group P received 40 mg of parecoxib by intravenous bolus injection and group S received the same volume of normal saline in the same way just after the induction of anesthesia. Hemodynamic parameters and body temperatures including tympanic and axillary temperature were monitored. The occurrence of shivering and pain intensity score were recorded during the recovery period. RESULTS: Parecoxib significantly reduced the incidence and severity of shivering in comparison with the placebo. Postoperative shivering was observed in 22 patients in group S (55%), compared with nine in group P (22.5%) (P = 0.003). In addition, pain intensity scores were lower in group P during recovery period; consequently, less rescue analgesics were required in group P when compared with group S (P = 0.001). Regarding the body temperature, it was found that core temperature decreased but peripheral temperature increased significantly in both groups. There was no significant difference between groups in all time intervals. CONCLUSIONS: Prophylactic administration of parecoxib produces dual effects on antishivering and postoperative analgesia. This implies that cyclooxygenase 2-prostaglandin E2 pathways may be involved in the regulation of shivering. SN - 1095-8673 UR - https://www.unboundmedicine.com/medline/citation/25908099/Parecoxib_for_the_prevention_of_shivering_after_general_anesthesia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-4804(15)00279-6 DB - PRIME DP - Unbound Medicine ER -