Citation
Madhi, Shabir A., et al. "Longitudinal Study On Streptococcus Pneumoniae, Haemophilus Influenzae and Staphylococcus Aureus Nasopharyngeal Colonization in HIV-infected and -uninfected Infants Vaccinated With Pneumococcal Conjugate Vaccine." Vaccine, vol. 33, no. 23, 2015, pp. 2662-9.
Madhi SA, Izu A, Nunes MC, et al. Longitudinal study on Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus nasopharyngeal colonization in HIV-infected and -uninfected infants vaccinated with pneumococcal conjugate vaccine. Vaccine. 2015;33(23):2662-9.
Madhi, S. A., Izu, A., Nunes, M. C., Violari, A., Cotton, M. F., Jean-Philippe, P., Klugman, K. P., von Gottberg, A., van Niekerk, N., & Adrian, P. V. (2015). Longitudinal study on Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus nasopharyngeal colonization in HIV-infected and -uninfected infants vaccinated with pneumococcal conjugate vaccine. Vaccine, 33(23), 2662-9. https://doi.org/10.1016/j.vaccine.2015.04.024
Madhi SA, et al. Longitudinal Study On Streptococcus Pneumoniae, Haemophilus Influenzae and Staphylococcus Aureus Nasopharyngeal Colonization in HIV-infected and -uninfected Infants Vaccinated With Pneumococcal Conjugate Vaccine. Vaccine. 2015 May 28;33(23):2662-9. PubMed PMID: 25910923.
TY - JOUR
T1 - Longitudinal study on Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus nasopharyngeal colonization in HIV-infected and -uninfected infants vaccinated with pneumococcal conjugate vaccine.
AU - Madhi,Shabir A,
AU - Izu,Alane,
AU - Nunes,Marta C,
AU - Violari,Avye,
AU - Cotton,Mark F,
AU - Jean-Philippe,Patrick,
AU - Klugman,Keith P,
AU - von Gottberg,Anne,
AU - van Niekerk,Nadia,
AU - Adrian,Peter V,
AU - ,,
Y1 - 2015/04/21/
PY - 2014/11/04/received
PY - 2015/04/07/revised
PY - 2015/04/10/accepted
PY - 2015/4/26/entrez
PY - 2015/4/26/pubmed
PY - 2016/1/28/medline
KW - Colonization
KW - HIV
KW - HIV exposure
KW - Haemophilus influenzae
KW - Pneumococcal conjugate vaccine
KW - Staphylococcus aureus
KW - Streptococcus pneumoniae
SP - 2662
EP - 9
JF - Vaccine
JO - Vaccine
VL - 33
IS - 23
N2 - BACKGROUND: Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus are all potentially pathogenic, which frequently colonize the nasopharynx (NP) prior to causing disease. We studied bacterial NP-colonization in 321 HIV-infected and 243 HIV-uninfected children vaccinated with 7-valent pneumococcal conjugate vaccine (PCV7) at 6, 10 and 14 weeks of age. METHODS: HIV-uninfected infants included those born to HIV-uninfected (HUU) and HIV-infected women (HEU); HIV-infected children with CD4+ lymphocyte ≥25% were randomized to initiate antiretroviral therapy immediately (ART-Immed) or when clinically indicated (ART-Def). Nasopharyngeal swabs for bacterial culture were taken prior to each PCV7 dose (Visits 1-3) and at 20, 39, 47 and 67 weeks of age (Visits 4-7). Swabs were cultured by standard methods and pneumococcal serotyping done by the Quellung method. RESULTS: Colonization patterns for pneumococcus, H. influenzae and S. aureus did not differ between HUU and HEU children; and were also generally similar between ART-Def and ART-Immed children. Prevalence of PCV7-serotype colonization was similar between HIV-infected and HIV-uninfected children, however, overall pneumococcal and specifically non-vaccine serotype colonization tended to be lower in HIV-infected children. HIV-infected children also had a 44% lower prevalence of S. aureus colonization at Visit-1 (p=0.010); and H. influenzae colonization was also lower among HIV-infected than HIV-uninfected children at Visit-2, Visit-3, Visit-6 and Visit-7. CONCLUSION: Vaccine-serotype colonization is similar in PCV-immunized HIV-infected and HIV-uninfected children. We, however, identified a lower prevalence of overall-pneumococcal and H. influenzae colonization in HIV-infected children post-PCV vaccination, the clinical-relevance of which warrants further study.
SN - 1873-2518
UR - https://www.unboundmedicine.com/medline/citation/25910923/Longitudinal_study_on_Streptococcus_pneumoniae_Haemophilus_influenzae_and_Staphylococcus_aureus_nasopharyngeal_colonization_in_HIV_infected_and__uninfected_infants_vaccinated_with_pneumococcal_conjugate_vaccine_
L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(15)00477-6
DB - PRIME
DP - Unbound Medicine
ER -