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Lymph node ratio may predict relapse free survival and overall survival in patients with stage II & III colorectal carcinoma.
Hepatogastroenterology. 2015 Mar-Apr; 62(138):291-4.H

Abstract

BACKGROUND/AIMS

Lymph node ratio (LNR) defined as the number of lymph nodes (LNs) involved with metastases divided by number of LNs examined, has been shown to be an independent prognostic factor in breast, stomach and various other solid tumors. Its significance as a prognostic determinant in colorectal cancer (CRC) is still under investigation. This study investigated the prognostic value of LNR in patients with resected CRC.

METHODOLOGY

We retrospectively ex- amined 145 patients with stage II & III CRC diagnosed and treated at a single institution during 9 years pe- riod. Patients were grouped according to LNR in three groups. Group 1; LNR < 0.05, Group 2; LNR = 0.05-0.19 & Group 3 > 0.19. Chi square, life table analysis and multivariate Cox regression were used for statistical analysis.

RESULTS

On multivariate analysis, number of involved LNs (NILN) (HR = 1.15, 95% CI 1.055-1.245; P = 0.001) and pathological T stage (P = 0.002) were statistically significant predictors of relapse free survival (RFS). LNR as a continuous variable (but not as a categorical variable) was statistically significant predictor of RFS (P = 0.02). LNR was also a statistically significant predictor of overall survival (OS) (P = 0.02).

CONCLUSION

LNR may predict RFS and OS in patients with resected stage II & III CRC. Studies with larger cohorts and longer follow up are needed to further examine and validate theprognostic value of LNR.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

25916051

Citation

Zekri, Jamal, et al. "Lymph Node Ratio May Predict Relapse Free Survival and Overall Survival in Patients With Stage II & III Colorectal Carcinoma." Hepato-gastroenterology, vol. 62, no. 138, 2015, pp. 291-4.
Zekri J, Ahmad I, Fawzy E, et al. Lymph node ratio may predict relapse free survival and overall survival in patients with stage II & III colorectal carcinoma. Hepatogastroenterology. 2015;62(138):291-4.
Zekri, J., Ahmad, I., Fawzy, E., Elkhodary, T. R., Al-Gahmi, A., Hassouna, A., El Sayed, M. E., Ur Rehman, J., Karim, S. M., & Bin Sadiq, B. (2015). Lymph node ratio may predict relapse free survival and overall survival in patients with stage II & III colorectal carcinoma. Hepato-gastroenterology, 62(138), 291-4.
Zekri J, et al. Lymph Node Ratio May Predict Relapse Free Survival and Overall Survival in Patients With Stage II & III Colorectal Carcinoma. Hepatogastroenterology. 2015 Mar-Apr;62(138):291-4. PubMed PMID: 25916051.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lymph node ratio may predict relapse free survival and overall survival in patients with stage II & III colorectal carcinoma. AU - Zekri,Jamal, AU - Ahmad,Imran, AU - Fawzy,Ehab, AU - Elkhodary,Tawfik R, AU - Al-Gahmi,Aboelkhair, AU - Hassouna,Ashraf, AU - El Sayed,Mohamed E, AU - Ur Rehman,Jalil, AU - Karim,Syed M, AU - Bin Sadiq,Bakr, PY - 2015/4/29/entrez PY - 2015/4/29/pubmed PY - 2015/6/17/medline SP - 291 EP - 4 JF - Hepato-gastroenterology JO - Hepatogastroenterology VL - 62 IS - 138 N2 - BACKGROUND/AIMS: Lymph node ratio (LNR) defined as the number of lymph nodes (LNs) involved with metastases divided by number of LNs examined, has been shown to be an independent prognostic factor in breast, stomach and various other solid tumors. Its significance as a prognostic determinant in colorectal cancer (CRC) is still under investigation. This study investigated the prognostic value of LNR in patients with resected CRC. METHODOLOGY: We retrospectively ex- amined 145 patients with stage II & III CRC diagnosed and treated at a single institution during 9 years pe- riod. Patients were grouped according to LNR in three groups. Group 1; LNR < 0.05, Group 2; LNR = 0.05-0.19 & Group 3 > 0.19. Chi square, life table analysis and multivariate Cox regression were used for statistical analysis. RESULTS: On multivariate analysis, number of involved LNs (NILN) (HR = 1.15, 95% CI 1.055-1.245; P = 0.001) and pathological T stage (P = 0.002) were statistically significant predictors of relapse free survival (RFS). LNR as a continuous variable (but not as a categorical variable) was statistically significant predictor of RFS (P = 0.02). LNR was also a statistically significant predictor of overall survival (OS) (P = 0.02). CONCLUSION: LNR may predict RFS and OS in patients with resected stage II & III CRC. Studies with larger cohorts and longer follow up are needed to further examine and validate theprognostic value of LNR. SN - 0172-6390 UR - https://www.unboundmedicine.com/medline/citation/25916051/Lymph_node_ratio_may_predict_relapse_free_survival_and_overall_survival_in_patients_with_stage_II_&_III_colorectal_carcinoma_ L2 - https://medlineplus.gov/colorectalcancer.html DB - PRIME DP - Unbound Medicine ER -