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Uptake routes and toxicokinetics of silver nanoparticles and silver ions in the earthworm Lumbricus rubellus.
Environ Toxicol Chem. 2015 Oct; 34(10):2263-70.ET

Abstract

Current bioavailability models, such as the free ion activity model and biotic ligand model, explicitly consider that metal exposure will be mainly to the dissolved metal in ionic form. With the rise of nanotechnology products and the increasing release of metal-based nanoparticles (NPs) to the environment, such models may increasingly be applied to support risk assessment. It is not immediately clear, however, whether the assumption of metal ion exposure will be relevant for NPs. Using an established approach of oral gluing, a toxicokinetics study was conducted to investigate the routes of silver nanoparticles (AgNPs) and Ag(+) ion uptake in the soil-dwelling earthworm Lumbricus rubellus. The results indicated that a significant part of the Ag uptake in the earthworms is through oral/gut uptake for both Ag(+) ions and NPs. Thus, sealing the mouth reduced Ag uptake by between 40% and 75%. An X-ray analysis of the internal distribution of Ag in transverse sections confirmed the presence of increased Ag concentrations in exposed earthworm tissues. For the AgNPs but not the Ag(+) ions, high concentrations were associated with the gut wall, liver-like chloragogenous tissue, and nephridia, which suggest a pathway for AgNP uptake, detoxification, and excretion via these organs. Overall, the results indicate that Ag in the ionic and NP forms is assimilated and internally distributed in earthworms and that this uptake occurs predominantly via the gut epithelium and less so via the body wall. The importance of oral exposure questions the application of current metal bioavailability models, which implicitly consider that the dominant route of exposure is via the soil solution, for bioavailability assessment and modeling of metal-based NPs.

Authors+Show Affiliations

Centre for Ecology and Hydrology, Crowmarsh Gifford, Wallingford, Oxfordshire, United Kingdom.Centre for Ecology and Hydrology, Crowmarsh Gifford, Wallingford, Oxfordshire, United Kingdom.Cardiff School of Biosciences, University of Cardiff, Cardiff, Wales, United Kingdom.Cardiff School of Biosciences, University of Cardiff, Cardiff, Wales, United Kingdom.Cardiff School of Biosciences, University of Cardiff, Cardiff, Wales, United Kingdom.Department of Materials, Oxford University, Yarnton, Oxfordshire, United Kingdom.Department of Ecological Science, Faculty of Earth and Life Sciences, VU University, Amsterdam, The Netherlands.Diamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire, United Kingdom.Centre for Ecology and Hydrology, Crowmarsh Gifford, Wallingford, Oxfordshire, United Kingdom.Centre for Ecology and Hydrology, Crowmarsh Gifford, Wallingford, Oxfordshire, United Kingdom.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25917164

Citation

Diez-Ortiz, Maria, et al. "Uptake Routes and Toxicokinetics of Silver Nanoparticles and Silver Ions in the Earthworm Lumbricus Rubellus." Environmental Toxicology and Chemistry, vol. 34, no. 10, 2015, pp. 2263-70.
Diez-Ortiz M, Lahive E, Kille P, et al. Uptake routes and toxicokinetics of silver nanoparticles and silver ions in the earthworm Lumbricus rubellus. Environ Toxicol Chem. 2015;34(10):2263-70.
Diez-Ortiz, M., Lahive, E., Kille, P., Powell, K., Morgan, A. J., Jurkschat, K., Van Gestel, C. A., Mosselmans, J. F., Svendsen, C., & Spurgeon, D. J. (2015). Uptake routes and toxicokinetics of silver nanoparticles and silver ions in the earthworm Lumbricus rubellus. Environmental Toxicology and Chemistry, 34(10), 2263-70. https://doi.org/10.1002/etc.3036
Diez-Ortiz M, et al. Uptake Routes and Toxicokinetics of Silver Nanoparticles and Silver Ions in the Earthworm Lumbricus Rubellus. Environ Toxicol Chem. 2015;34(10):2263-70. PubMed PMID: 25917164.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Uptake routes and toxicokinetics of silver nanoparticles and silver ions in the earthworm Lumbricus rubellus. AU - Diez-Ortiz,Maria, AU - Lahive,Elma, AU - Kille,Peter, AU - Powell,Kate, AU - Morgan,A John, AU - Jurkschat,Kerstin, AU - Van Gestel,Cornelis A M, AU - Mosselmans,J Fred W, AU - Svendsen,Claus, AU - Spurgeon,David J, Y1 - 2015/09/11/ PY - 2014/06/16/received PY - 2014/08/14/revised PY - 2015/04/24/accepted PY - 2015/4/29/entrez PY - 2015/4/29/pubmed PY - 2016/5/11/medline KW - Exposure route KW - Nanoparticles KW - Silver KW - Uptake KW - X-ray absorption near-edge spectroscopy SP - 2263 EP - 70 JF - Environmental toxicology and chemistry JO - Environ Toxicol Chem VL - 34 IS - 10 N2 - Current bioavailability models, such as the free ion activity model and biotic ligand model, explicitly consider that metal exposure will be mainly to the dissolved metal in ionic form. With the rise of nanotechnology products and the increasing release of metal-based nanoparticles (NPs) to the environment, such models may increasingly be applied to support risk assessment. It is not immediately clear, however, whether the assumption of metal ion exposure will be relevant for NPs. Using an established approach of oral gluing, a toxicokinetics study was conducted to investigate the routes of silver nanoparticles (AgNPs) and Ag(+) ion uptake in the soil-dwelling earthworm Lumbricus rubellus. The results indicated that a significant part of the Ag uptake in the earthworms is through oral/gut uptake for both Ag(+) ions and NPs. Thus, sealing the mouth reduced Ag uptake by between 40% and 75%. An X-ray analysis of the internal distribution of Ag in transverse sections confirmed the presence of increased Ag concentrations in exposed earthworm tissues. For the AgNPs but not the Ag(+) ions, high concentrations were associated with the gut wall, liver-like chloragogenous tissue, and nephridia, which suggest a pathway for AgNP uptake, detoxification, and excretion via these organs. Overall, the results indicate that Ag in the ionic and NP forms is assimilated and internally distributed in earthworms and that this uptake occurs predominantly via the gut epithelium and less so via the body wall. The importance of oral exposure questions the application of current metal bioavailability models, which implicitly consider that the dominant route of exposure is via the soil solution, for bioavailability assessment and modeling of metal-based NPs. SN - 1552-8618 UR - https://www.unboundmedicine.com/medline/citation/25917164/Uptake_routes_and_toxicokinetics_of_silver_nanoparticles_and_silver_ions_in_the_earthworm_Lumbricus_rubellus_ L2 - https://doi.org/10.1002/etc.3036 DB - PRIME DP - Unbound Medicine ER -