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The effect of fruit and vegetable intake on the development of lung cancer: a meta-analysis of 32 publications and 20,414 cases.

Abstract

BACKGROUND/OBJECTIVES

Quantification of the association between the intake of vegetables and fruits and the risk of lung cancer is controversial. Thus, we conducted a meta-analysis to assess the relationship between vegetables and fruits and lung cancer risk.

SUBJECTS/METHODS

Pertinent studies were identified by a search in PubMed and Web of Knowledge. Random-effects models were used to calculate summary relative risks (RR) and the corresponding 95% confidence intervals (CI). Publication bias was estimated using Begg's test.

RESULTS

Finally, 30 articles with 37 studies comprising of 20,075 lung cancer cases for vegetables intake with lung cancer risk and 31 articles with 38 studies comprising of 20,213 lung cancer cases for fruits intake with lung cancer risk were included in this meta-analysis. The combined results showed that there were significant associations between vegetables and fruits intake and lung cancer risk. The pooled RR were 0.74 (95% CI: 0.67, 0.82) for vegetables and 0.80 (95% CI: 0.74, 0.88) for fruits. Significant association was found in females on vegetables intake and lung cancer but not in males. The association was also stronger in females than males on fruits intake and lung cancer risk. No publication bias was detected.

CONCLUSIONS

Our analysis indicated that intake of vegetables and fruits may have a protective effect on lung cancer, and the associations were stronger in females. As the potential biases and confounders could not be ruled out completely in this meta-analysis, further studies are needed.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Vascular Surgery, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, PR China.

    ,

    Department of Vascular Surgery, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, PR China.

    ,

    Department of Vascular Surgery, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, PR China.

    ,

    Department of Thoracic Surgery, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, PR China.

    Department of Vascular Surgery, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, PR China.

    Source

    European journal of clinical nutrition 69:11 2015 Nov pg 1184-92

    MeSH

    Adult
    Aged
    Aged, 80 and over
    Diet
    Feeding Behavior
    Female
    Fruit
    Humans
    Lung Neoplasms
    Male
    Middle Aged
    Vegetables
    Young Adult

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Review

    Language

    eng

    PubMed ID

    25920421

    Citation

    Wang, M, et al. "The Effect of Fruit and Vegetable Intake On the Development of Lung Cancer: a Meta-analysis of 32 Publications and 20,414 Cases." European Journal of Clinical Nutrition, vol. 69, no. 11, 2015, pp. 1184-92.
    Wang M, Qin S, Zhang T, et al. The effect of fruit and vegetable intake on the development of lung cancer: a meta-analysis of 32 publications and 20,414 cases. Eur J Clin Nutr. 2015;69(11):1184-92.
    Wang, M., Qin, S., Zhang, T., Song, X., & Zhang, S. (2015). The effect of fruit and vegetable intake on the development of lung cancer: a meta-analysis of 32 publications and 20,414 cases. European Journal of Clinical Nutrition, 69(11), pp. 1184-92. doi:10.1038/ejcn.2015.64.
    Wang M, et al. The Effect of Fruit and Vegetable Intake On the Development of Lung Cancer: a Meta-analysis of 32 Publications and 20,414 Cases. Eur J Clin Nutr. 2015;69(11):1184-92. PubMed PMID: 25920421.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The effect of fruit and vegetable intake on the development of lung cancer: a meta-analysis of 32 publications and 20,414 cases. AU - Wang,M, AU - Qin,S, AU - Zhang,T, AU - Song,X, AU - Zhang,S, Y1 - 2015/04/29/ PY - 2014/07/02/received PY - 2015/02/04/revised PY - 2015/03/17/accepted PY - 2015/4/30/entrez PY - 2015/4/30/pubmed PY - 2016/8/18/medline SP - 1184 EP - 92 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 69 IS - 11 N2 - BACKGROUND/OBJECTIVES: Quantification of the association between the intake of vegetables and fruits and the risk of lung cancer is controversial. Thus, we conducted a meta-analysis to assess the relationship between vegetables and fruits and lung cancer risk. SUBJECTS/METHODS: Pertinent studies were identified by a search in PubMed and Web of Knowledge. Random-effects models were used to calculate summary relative risks (RR) and the corresponding 95% confidence intervals (CI). Publication bias was estimated using Begg's test. RESULTS: Finally, 30 articles with 37 studies comprising of 20,075 lung cancer cases for vegetables intake with lung cancer risk and 31 articles with 38 studies comprising of 20,213 lung cancer cases for fruits intake with lung cancer risk were included in this meta-analysis. The combined results showed that there were significant associations between vegetables and fruits intake and lung cancer risk. The pooled RR were 0.74 (95% CI: 0.67, 0.82) for vegetables and 0.80 (95% CI: 0.74, 0.88) for fruits. Significant association was found in females on vegetables intake and lung cancer but not in males. The association was also stronger in females than males on fruits intake and lung cancer risk. No publication bias was detected. CONCLUSIONS: Our analysis indicated that intake of vegetables and fruits may have a protective effect on lung cancer, and the associations were stronger in females. As the potential biases and confounders could not be ruled out completely in this meta-analysis, further studies are needed. SN - 1476-5640 UR - https://www.unboundmedicine.com/medline/citation/25920421/The_effect_of_fruit_and_vegetable_intake_on_the_development_of_lung_cancer:_a_meta_analysis_of_32_publications_and_20414_cases_ L2 - http://dx.doi.org/10.1038/ejcn.2015.64 DB - PRIME DP - Unbound Medicine ER -