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Dietary style and acid load in an Italian population of calcium kidney stone formers.
Nutr Metab Cardiovasc Dis 2015; 25(6):588-93NM

Abstract

BACKGROUND AND AIMS

Animal protein intake may cause an acid load that predisposes individuals to stones by influencing calcium and citrate excretion. These associations were not confirmed in recent studies. Therefore the present study was aimed to compare acid load of diet in stone formers and controls.

METHODS AND RESULTS

Participants to the study were 157 consecutive calcium stone formers and 144 controls. Diet was analyzed in these subjects using a software that evaluated nutrient intake from a three-day food intake diary. This software also estimated the potential renal acid load (PRAL, mEq/day). Twenty-four-hour urine excretion of ions and citrate was measured in stone formers. Stone former diet had lower intake of glucose, fructose, potassium and fiber and higher PRAL in comparison with controls. The multinomial logistic regression analysis showed that stone risk decreased in association with the middle and the highest tertiles of fiber intake and increased in association with the highest tertile of PRAL. The linear multiple regression analysis showed that calcium excretion was associated with the sodium excretion and that citrate excretion was associated with the PRAL and animal protein intake in stone formers.

CONCLUSION

Our findings suggest that stone formers may undergo a greater dietary acid load sustained by a low vegetable intake and base provision. Dietary acid load does not appear as the main determinant of calcium excretion, but may promote stone risk by decreasing citrate excretion. Sodium intake may predispose to stones by stimulating calcium excretion.

Authors+Show Affiliations

Nephrology and Dialysis Unit, Postgraduate School of Nephrology, Vita Salute University, San Raffaele Scientific Institute, 20132 Milan, Italy. Electronic address: vezzoli.giuseppe@hsr.it.Department of Health Sciences, Università degli Studi di Milano, San Paolo Hospital, 20142 Milan, Italy.Department of Health Sciences, Università degli Studi di Milano, San Paolo Hospital, 20142 Milan, Italy; Sidra Medical and Research Center, Doha, Qatar.Nephrology and Dialysis Unit, Postgraduate School of Nephrology, Vita Salute University, San Raffaele Scientific Institute, 20132 Milan, Italy.Nephrology and Dialysis Unit, Postgraduate School of Nephrology, Vita Salute University, San Raffaele Scientific Institute, 20132 Milan, Italy.Department of Health Sciences, Università degli Studi di Milano, San Paolo Hospital, 20142 Milan, Italy.Department of Health Sciences, Università degli Studi di Milano, San Paolo Hospital, 20142 Milan, Italy.Nephrology and Dialysis Unit, Postgraduate School of Nephrology, Vita Salute University, San Raffaele Scientific Institute, 20132 Milan, Italy; Department of Health Sciences, Università degli Studi di Milano, San Paolo Hospital, 20142 Milan, Italy.Department of Health Sciences, Università degli Studi di Milano, San Paolo Hospital, 20142 Milan, Italy.Department of Clinical Sciences, University of Parma, Parma, Italy.Department of Clinical Sciences, University of Parma, Parma, Italy.Department of Health Sciences, Università degli Studi di Milano, San Paolo Hospital, 20142 Milan, Italy.Nephrology and Dialysis Unit, Postgraduate School of Nephrology, Vita Salute University, San Raffaele Scientific Institute, 20132 Milan, Italy.Urology, Department of Health Sciences, Università degli Studi di Milano, San Paolo Hospital, 20142 Milan, Italy.Department of Health Sciences, Università degli Studi di Milano, San Paolo Hospital, 20142 Milan, Italy.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25921845

Citation

Vezzoli, G, et al. "Dietary Style and Acid Load in an Italian Population of Calcium Kidney Stone Formers." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 25, no. 6, 2015, pp. 588-93.
Vezzoli G, Dogliotti E, Terranegra A, et al. Dietary style and acid load in an Italian population of calcium kidney stone formers. Nutr Metab Cardiovasc Dis. 2015;25(6):588-93.
Vezzoli, G., Dogliotti, E., Terranegra, A., Arcidiacono, T., Macrina, L., Tavecchia, M., ... Soldati, L. (2015). Dietary style and acid load in an Italian population of calcium kidney stone formers. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 25(6), pp. 588-93. doi:10.1016/j.numecd.2015.03.005.
Vezzoli G, et al. Dietary Style and Acid Load in an Italian Population of Calcium Kidney Stone Formers. Nutr Metab Cardiovasc Dis. 2015;25(6):588-93. PubMed PMID: 25921845.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary style and acid load in an Italian population of calcium kidney stone formers. AU - Vezzoli,G, AU - Dogliotti,E, AU - Terranegra,A, AU - Arcidiacono,T, AU - Macrina,L, AU - Tavecchia,M, AU - Pivari,F, AU - Mingione,A, AU - Brasacchio,C, AU - Nouvenne,A, AU - Meschi,T, AU - Cusi,D, AU - Spotti,D, AU - Montanari,E, AU - Soldati,L, Y1 - 2015/03/20/ PY - 2014/11/24/received PY - 2015/03/05/revised PY - 2015/03/11/accepted PY - 2015/4/30/entrez PY - 2015/4/30/pubmed PY - 2016/2/20/medline KW - Acid load KW - Calcium excretion KW - Citrate excretion KW - Kidney stones KW - Vegetable intake SP - 588 EP - 93 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 25 IS - 6 N2 - BACKGROUND AND AIMS: Animal protein intake may cause an acid load that predisposes individuals to stones by influencing calcium and citrate excretion. These associations were not confirmed in recent studies. Therefore the present study was aimed to compare acid load of diet in stone formers and controls. METHODS AND RESULTS: Participants to the study were 157 consecutive calcium stone formers and 144 controls. Diet was analyzed in these subjects using a software that evaluated nutrient intake from a three-day food intake diary. This software also estimated the potential renal acid load (PRAL, mEq/day). Twenty-four-hour urine excretion of ions and citrate was measured in stone formers. Stone former diet had lower intake of glucose, fructose, potassium and fiber and higher PRAL in comparison with controls. The multinomial logistic regression analysis showed that stone risk decreased in association with the middle and the highest tertiles of fiber intake and increased in association with the highest tertile of PRAL. The linear multiple regression analysis showed that calcium excretion was associated with the sodium excretion and that citrate excretion was associated with the PRAL and animal protein intake in stone formers. CONCLUSION: Our findings suggest that stone formers may undergo a greater dietary acid load sustained by a low vegetable intake and base provision. Dietary acid load does not appear as the main determinant of calcium excretion, but may promote stone risk by decreasing citrate excretion. Sodium intake may predispose to stones by stimulating calcium excretion. SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/25921845/Dietary_style_and_acid_load_in_an_Italian_population_of_calcium_kidney_stone_formers_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-4753(15)00061-7 DB - PRIME DP - Unbound Medicine ER -