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Is 25(OH)D Associated with Cognitive Impairment and Functional Improvement in Stroke? A Retrospective Clinical Study.
J Stroke Cerebrovasc Dis. 2015 Jul; 24(7):1479-86.JS

Abstract

BACKGROUND

In recent years, vitamin D deficiency has been suggested as a risk factor for ischemic stroke and stroke severity in both animal models and clinical studies. In this retrospective study, we investigated the relationship between 25-hydroxyvitamin D [25(OH)D] levels and functional outcomes in stroke patients during neurological rehabilitation program. We also investigated whether there is an association between 25(OH)D levels and cognitive impairment.

METHODS

The study included the medical records of 120 stroke patients who participated in a neurological rehabilitation program. The motor and cognitive components of the Functional Independence Measurements of all patients at admission and discharge were recorded. The Functional Ambulatory Scale was used to assess motor functional status, and the Turkish-validated version of the minimental state examination test was used to assess cognitive status.

RESULTS

A significant correlation was found between 25(OH)D level and cognitive impairment among patients who had ischemic strokes. High levels of 25(OH)D were associated with greater functional gain during the rehabilitation program in both ischemic stroke patients and hemorrhagic stroke patients.

CONCLUSIONS

High 25(OH)D levels might be associated with greater functional improvement and with less cognitive impairment in stroke patients.

Authors+Show Affiliations

Physical Medicine and Rehabilitation Department, Izmir Bozyaka Education and Research Hospital, Izmir, Turkey. Electronic address: senizakcay@hotmail.com.Physical Medicine and Rehabilitation Department, Namık Kemal University, Tekirdag, Turkey.Physical Medicine and Rehabilitation Department, Baskent University, Ankara, Turkey.Physical Medicine and Rehabilitation Department, Sevket Yilmaz Education and Research Hospital, Bursa, Turkey.Physical Medicine and Rehabilitation Department, Ankara Diskapi Education and Research Hospital, Ankara, Turkey.Physical Medicine and Rehabilitation Department, Sevket Yilmaz Education and Research Hospital, Bursa, Turkey.Physical Medicine and Rehabilitation Department, Sevket Yilmaz Education and Research Hospital, Bursa, Turkey.Physical Medicine and Rehabilitation Department, Namık Kemal University, Tekirdag, Turkey.

Pub Type(s)

Clinical Study
Journal Article

Language

eng

PubMed ID

25922112

Citation

Yalbuzdag, Seniz Akcay, et al. "Is 25(OH)D Associated With Cognitive Impairment and Functional Improvement in Stroke? a Retrospective Clinical Study." Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association, vol. 24, no. 7, 2015, pp. 1479-86.
Yalbuzdag SA, Sarifakioglu B, Afsar SI, et al. Is 25(OH)D Associated with Cognitive Impairment and Functional Improvement in Stroke? A Retrospective Clinical Study. J Stroke Cerebrovasc Dis. 2015;24(7):1479-86.
Yalbuzdag, S. A., Sarifakioglu, B., Afsar, S. I., Celik, C., Can, A., Yegin, T., Senturk, B., & Guzelant, A. Y. (2015). Is 25(OH)D Associated with Cognitive Impairment and Functional Improvement in Stroke? A Retrospective Clinical Study. Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association, 24(7), 1479-86. https://doi.org/10.1016/j.jstrokecerebrovasdis.2015.03.007
Yalbuzdag SA, et al. Is 25(OH)D Associated With Cognitive Impairment and Functional Improvement in Stroke? a Retrospective Clinical Study. J Stroke Cerebrovasc Dis. 2015;24(7):1479-86. PubMed PMID: 25922112.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is 25(OH)D Associated with Cognitive Impairment and Functional Improvement in Stroke? A Retrospective Clinical Study. AU - Yalbuzdag,Seniz Akcay, AU - Sarifakioglu,Banu, AU - Afsar,Sevgi Ikbali, AU - Celik,Canan, AU - Can,Aslı, AU - Yegin,Tugba, AU - Senturk,Burcu, AU - Guzelant,Aliye Yildirim, Y1 - 2015/04/25/ PY - 2014/09/23/received PY - 2015/03/02/revised PY - 2015/03/08/accepted PY - 2015/4/30/entrez PY - 2015/4/30/pubmed PY - 2016/3/11/medline KW - Stroke KW - cognitive function KW - rehabilitation KW - vitamin D SP - 1479 EP - 86 JF - Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association JO - J Stroke Cerebrovasc Dis VL - 24 IS - 7 N2 - BACKGROUND: In recent years, vitamin D deficiency has been suggested as a risk factor for ischemic stroke and stroke severity in both animal models and clinical studies. In this retrospective study, we investigated the relationship between 25-hydroxyvitamin D [25(OH)D] levels and functional outcomes in stroke patients during neurological rehabilitation program. We also investigated whether there is an association between 25(OH)D levels and cognitive impairment. METHODS: The study included the medical records of 120 stroke patients who participated in a neurological rehabilitation program. The motor and cognitive components of the Functional Independence Measurements of all patients at admission and discharge were recorded. The Functional Ambulatory Scale was used to assess motor functional status, and the Turkish-validated version of the minimental state examination test was used to assess cognitive status. RESULTS: A significant correlation was found between 25(OH)D level and cognitive impairment among patients who had ischemic strokes. High levels of 25(OH)D were associated with greater functional gain during the rehabilitation program in both ischemic stroke patients and hemorrhagic stroke patients. CONCLUSIONS: High 25(OH)D levels might be associated with greater functional improvement and with less cognitive impairment in stroke patients. SN - 1532-8511 UR - https://www.unboundmedicine.com/medline/citation/25922112/Is_25_OH_D_Associated_with_Cognitive_Impairment_and_Functional_Improvement_in_Stroke_A_Retrospective_Clinical_Study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1052-3057(15)00119-6 DB - PRIME DP - Unbound Medicine ER -