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Adiponectin levels in gestational diabetes mellitus and in pregnant women without glucose intolerance.
Adv Clin Exp Med. 2015 Jan-Feb; 24(1):85-92.AC

Abstract

OBJECTIVES

The aim of the study was to determine serum adiponectin levels among patients with gestational diabetes mellitus (GDM) and normal pregnant women without glucose intolerance, and to investigate the relationship between these levels and clinical factors at the time of the diagnosis, at delivery and in the post-partum period.

MATERIAL AND METHODS

The subjects' serum adiponectin concentration was measured using the enzyme-linked immunosorbent assay (ELISA) method at 24th-28th week of gestation, at delivery (in maternal circulation and the umbilical cord) and 24 h after delivery. The relationship between these groups' measurements and other established clinical-laboratory factors were investigated.

RESULTS

Serum adiponectin concentrations were significantly lower (p = 0.02) in GDM patients compared with patients with normal glucose tolerance at 24th-28th week of gestation. During delivery, maternal serum adiponectin concentrations were significantly lower (p = 0.03) in GDM patients compared with patients with normal glucose tolerance. In the post-partum period, serum adiponectin concentrations were significantly higher (p = 0.009) in GDM patients compared with patients with normal glucose tolerance. Umbilical cord adiponectin concentrations were significantly lower (p = 0.005) in GDM patients compared with patients with normal glucose tolerance.

CONCLUSIONS

Adiponectin concentrations in GDM patients' circulation were regulated by changes in glucose and insulin metabolism. A reduction in serum adiponectin levels seems to play a role in GDM patients' insulin resistance.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Perinatology Division, Celal Bayar University, School of Medicine, Manisa, Turkey.Elbistan Government Hospital, Kahramanmaras, Turkey.Department of Internal Medicine, Division of Endocrinology, Dokuz Eylul University, School of Medicine, Izmir, Turkey.Celal Bayar University, Vocational School of Health Sciences, Manisa, Turkey.Biochemistry Department, Dokuz Eylul University, School of Medicine, Izmir, Turkey.Obstetrics and Gynecology Department, Dokuz Eylul University, School of Medicine, Izmir, Turkey.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25923091

Citation

Pala, Halil G., et al. "Adiponectin Levels in Gestational Diabetes Mellitus and in Pregnant Women Without Glucose Intolerance." Advances in Clinical and Experimental Medicine : Official Organ Wroclaw Medical University, vol. 24, no. 1, 2015, pp. 85-92.
Pala HG, Ozalp Y, Yener AS, et al. Adiponectin levels in gestational diabetes mellitus and in pregnant women without glucose intolerance. Adv Clin Exp Med. 2015;24(1):85-92.
Pala, H. G., Ozalp, Y., Yener, A. S., Gerceklioglu, G., Uysal, S., & Onvural, A. (2015). Adiponectin levels in gestational diabetes mellitus and in pregnant women without glucose intolerance. Advances in Clinical and Experimental Medicine : Official Organ Wroclaw Medical University, 24(1), 85-92. https://doi.org/10.17219/acem/38141
Pala HG, et al. Adiponectin Levels in Gestational Diabetes Mellitus and in Pregnant Women Without Glucose Intolerance. Adv Clin Exp Med. 2015;24(1):85-92. PubMed PMID: 25923091.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adiponectin levels in gestational diabetes mellitus and in pregnant women without glucose intolerance. AU - Pala,Halil G, AU - Ozalp,Yılmaz, AU - Yener,Abdullah S, AU - Gerceklioglu,Gul, AU - Uysal,Sezer, AU - Onvural,Ata, PY - 2015/4/30/entrez PY - 2015/4/30/pubmed PY - 2015/6/3/medline SP - 85 EP - 92 JF - Advances in clinical and experimental medicine : official organ Wroclaw Medical University JO - Adv Clin Exp Med VL - 24 IS - 1 N2 - OBJECTIVES: The aim of the study was to determine serum adiponectin levels among patients with gestational diabetes mellitus (GDM) and normal pregnant women without glucose intolerance, and to investigate the relationship between these levels and clinical factors at the time of the diagnosis, at delivery and in the post-partum period. MATERIAL AND METHODS: The subjects' serum adiponectin concentration was measured using the enzyme-linked immunosorbent assay (ELISA) method at 24th-28th week of gestation, at delivery (in maternal circulation and the umbilical cord) and 24 h after delivery. The relationship between these groups' measurements and other established clinical-laboratory factors were investigated. RESULTS: Serum adiponectin concentrations were significantly lower (p = 0.02) in GDM patients compared with patients with normal glucose tolerance at 24th-28th week of gestation. During delivery, maternal serum adiponectin concentrations were significantly lower (p = 0.03) in GDM patients compared with patients with normal glucose tolerance. In the post-partum period, serum adiponectin concentrations were significantly higher (p = 0.009) in GDM patients compared with patients with normal glucose tolerance. Umbilical cord adiponectin concentrations were significantly lower (p = 0.005) in GDM patients compared with patients with normal glucose tolerance. CONCLUSIONS: Adiponectin concentrations in GDM patients' circulation were regulated by changes in glucose and insulin metabolism. A reduction in serum adiponectin levels seems to play a role in GDM patients' insulin resistance. SN - 1899-5276 UR - https://www.unboundmedicine.com/medline/citation/25923091/Adiponectin_levels_in_gestational_diabetes_mellitus_and_in_pregnant_women_without_glucose_intolerance_ L2 - http://www.advances.am.wroc.pl/pdf/2015/24/1/85.pdf DB - PRIME DP - Unbound Medicine ER -