Tags

Type your tag names separated by a space and hit enter

Flavonoids from Artocarpus anisophyllus and their bioactivities.
Nat Prod Commun. 2015 Mar; 10(3):393-6.NP

Abstract

Two new prenylated flavonoids, 4',5-dihydroxy-6,7-(2,2-dimethylpyrano)-2'-methoxy-8-γ,γ-dimethylallylflavone 1 and 3'-hydroxycycloartocarpin 2 along with six known flavonoids, 5,7-dihydroxy-4'-methoxy-8-prenylflavanone 3, isobavachalcone 4, pyranocycloartobiloxanthone A 5, artocarpin 6, chaplashin 7 and cycloartocarpin 8 were isolated for the first time from the leaves and the heartwoods of Artocarpus anisophyllus Miq. The structures of isolated flavonoids were elucidated spectroscopically using 1D and 2D NMR, FTIR, MS, UV and also by comparison with literature data. These flavonoids were screened for their antioxidant and tyrosinase inhibitory activities. The dichloromethane and ethyl acetate crude extracts together with 3'-hydroxycycloartocarpin 2, pyranocycloartobiloxanthone A 5 and artocarpin 6 showed DPPH (2,2-diphenyl-l-picrylhydrazyl) radical scavenging activity with SC50 values of 80.2, 40.0, 152.9, 20.2 and 140.0 μg/mL in 30 min, respectively. Pyranocycloartobiloxanthone A 5 exhibited significant tyrosinase inhibitory activity against tyrosinase from mushroom with IC50 values of 60.5 μg/mL.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25924513

Citation

Lathiff, Siti Mariam Abdul, et al. "Flavonoids From Artocarpus Anisophyllus and Their Bioactivities." Natural Product Communications, vol. 10, no. 3, 2015, pp. 393-6.
Lathiff SM, Jemaon N, Abdullah SA, et al. Flavonoids from Artocarpus anisophyllus and their bioactivities. Nat Prod Commun. 2015;10(3):393-6.
Lathiff, S. M., Jemaon, N., Abdullah, S. A., & Jamil, S. (2015). Flavonoids from Artocarpus anisophyllus and their bioactivities. Natural Product Communications, 10(3), 393-6.
Lathiff SM, et al. Flavonoids From Artocarpus Anisophyllus and Their Bioactivities. Nat Prod Commun. 2015;10(3):393-6. PubMed PMID: 25924513.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Flavonoids from Artocarpus anisophyllus and their bioactivities. AU - Lathiff,Siti Mariam Abdul, AU - Jemaon,Noraini, AU - Abdullah,Siti Awanis, AU - Jamil,Shajarahtunnur, PY - 2015/5/1/entrez PY - 2015/5/1/pubmed PY - 2015/6/17/medline SP - 393 EP - 6 JF - Natural product communications JO - Nat Prod Commun VL - 10 IS - 3 N2 - Two new prenylated flavonoids, 4',5-dihydroxy-6,7-(2,2-dimethylpyrano)-2'-methoxy-8-γ,γ-dimethylallylflavone 1 and 3'-hydroxycycloartocarpin 2 along with six known flavonoids, 5,7-dihydroxy-4'-methoxy-8-prenylflavanone 3, isobavachalcone 4, pyranocycloartobiloxanthone A 5, artocarpin 6, chaplashin 7 and cycloartocarpin 8 were isolated for the first time from the leaves and the heartwoods of Artocarpus anisophyllus Miq. The structures of isolated flavonoids were elucidated spectroscopically using 1D and 2D NMR, FTIR, MS, UV and also by comparison with literature data. These flavonoids were screened for their antioxidant and tyrosinase inhibitory activities. The dichloromethane and ethyl acetate crude extracts together with 3'-hydroxycycloartocarpin 2, pyranocycloartobiloxanthone A 5 and artocarpin 6 showed DPPH (2,2-diphenyl-l-picrylhydrazyl) radical scavenging activity with SC50 values of 80.2, 40.0, 152.9, 20.2 and 140.0 μg/mL in 30 min, respectively. Pyranocycloartobiloxanthone A 5 exhibited significant tyrosinase inhibitory activity against tyrosinase from mushroom with IC50 values of 60.5 μg/mL. SN - 1934-578X UR - https://www.unboundmedicine.com/medline/citation/25924513/Flavonoids_from_Artocarpus_anisophyllus_and_their_bioactivities_ DB - PRIME DP - Unbound Medicine ER -