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Clinical and laboratory profiles of primary Sjogren's syndrome in a Chinese population: A retrospective analysis of 315 patients.
Int J Rheum Dis. 2015 May; 18(4):439-46.IJ

Abstract

AIM

To assess the clinical and laboratory features of primary Sjogren's syndrome (pSS) in a large teaching hospital in China.

METHODS

Three hundred and fifteen pSS patients diagnosed according to American-European Classification Criteria and consecutively admitted to Anhui Provincial Hospital from 1 January 1999 to 30 September 2012 were retrospectively selected in this study.

RESULTS

The median age was 46.8 ± 14.4 years (range 13-83 years) and the majority of patients were female (96.5%). The common clinical features at initial presentations were dry mouth (50.2%), dry eyes (31.4%) and joint pain (24.8%); 92.6% of patients had positive anti-SSA antibody and 49.2% patients had positive anti-SSB antibody. One hundred and eighteen patients underwent labial salivary gland biopsy. According to Chisholm grading criteria, grade 3 to 4 was present in 58.5% of the patients. The frequency of interstitial lung disease (ILD) occurred (20.9%) in the patients with systemic extraglandular manifestations. The patients with ILD were frequently associated with positive anti-SSA (P = 0.005) and low levels of C3. The most common impairment of lung function was small airway function abnormalities. Sixty-six pSS patients with ILD (pSS-ILD) were diagnosed with high-resolution computed tomography and treated with corticosteroids and/or immunosuppressants, in which 18 patients had improved pulmonary function.

CONCLUSION

Labial salivary gland biopsy and anti-nuclear antibodies spectrum were important to the diagnosis of pSS. The pSS patients had high percentage of ILD, especially small airway function abnormalities. The combination of corticosteroids and immunosuppressants appears to be effective in treatment of pSS patients with ILD.

Authors+Show Affiliations

Department of Rheumatology and Immunology, Anhui Medical University Affiliated Provincial Hospital, Hefei, China.Department of Rheumatology and Immunology, The Third Affiliated Hospital of Anhui Medical University and the First People' Hospital of Hefei, Hefei, China.Department of Rheumatology and Immunology, Anhui Medical University Affiliated Provincial Hospital, Hefei, China.Department of Rheumatology and Immunology, Anhui Medical University Affiliated Provincial Hospital, Hefei, China.Department of Radiology, Anhui Medical University Affiliated Provincial Hospital, Hefei, China.Department of Rheumatology and Immunology, Anhui Medical University Affiliated Provincial Hospital, Hefei, China.Department of Rheumatology and Immunology, Anhui Medical University Affiliated Provincial Hospital, Hefei, China.Department of Rheumatology and Immunology, Anhui Medical University Affiliated Provincial Hospital, Hefei, China.Medicines Monitoring Unit, Division of Medical Sciences, University of Dundee, Dundee, UK.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25925697

Citation

Li, Xiaomei, et al. "Clinical and Laboratory Profiles of Primary Sjogren's Syndrome in a Chinese Population: a Retrospective Analysis of 315 Patients." International Journal of Rheumatic Diseases, vol. 18, no. 4, 2015, pp. 439-46.
Li X, Xu B, Ma Y, et al. Clinical and laboratory profiles of primary Sjogren's syndrome in a Chinese population: A retrospective analysis of 315 patients. Int J Rheum Dis. 2015;18(4):439-46.
Li, X., Xu, B., Ma, Y., Li, X., Cheng, Q., Wang, X., Wang, G., Qian, L., & Wei, L. (2015). Clinical and laboratory profiles of primary Sjogren's syndrome in a Chinese population: A retrospective analysis of 315 patients. International Journal of Rheumatic Diseases, 18(4), 439-46. https://doi.org/10.1111/1756-185X.12583
Li X, et al. Clinical and Laboratory Profiles of Primary Sjogren's Syndrome in a Chinese Population: a Retrospective Analysis of 315 Patients. Int J Rheum Dis. 2015;18(4):439-46. PubMed PMID: 25925697.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical and laboratory profiles of primary Sjogren's syndrome in a Chinese population: A retrospective analysis of 315 patients. AU - Li,Xiaomei, AU - Xu,Bei, AU - Ma,Yan, AU - Li,Xiangpei, AU - Cheng,Qi, AU - Wang,Ximei, AU - Wang,Guosheng, AU - Qian,Long, AU - Wei,Li, Y1 - 2015/04/30/ PY - 2015/5/1/entrez PY - 2015/5/1/pubmed PY - 2016/4/23/medline KW - complications KW - primary Sjogren's syndrome KW - retrospective analysis SP - 439 EP - 46 JF - International journal of rheumatic diseases JO - Int J Rheum Dis VL - 18 IS - 4 N2 - AIM: To assess the clinical and laboratory features of primary Sjogren's syndrome (pSS) in a large teaching hospital in China. METHODS: Three hundred and fifteen pSS patients diagnosed according to American-European Classification Criteria and consecutively admitted to Anhui Provincial Hospital from 1 January 1999 to 30 September 2012 were retrospectively selected in this study. RESULTS: The median age was 46.8 ± 14.4 years (range 13-83 years) and the majority of patients were female (96.5%). The common clinical features at initial presentations were dry mouth (50.2%), dry eyes (31.4%) and joint pain (24.8%); 92.6% of patients had positive anti-SSA antibody and 49.2% patients had positive anti-SSB antibody. One hundred and eighteen patients underwent labial salivary gland biopsy. According to Chisholm grading criteria, grade 3 to 4 was present in 58.5% of the patients. The frequency of interstitial lung disease (ILD) occurred (20.9%) in the patients with systemic extraglandular manifestations. The patients with ILD were frequently associated with positive anti-SSA (P = 0.005) and low levels of C3. The most common impairment of lung function was small airway function abnormalities. Sixty-six pSS patients with ILD (pSS-ILD) were diagnosed with high-resolution computed tomography and treated with corticosteroids and/or immunosuppressants, in which 18 patients had improved pulmonary function. CONCLUSION: Labial salivary gland biopsy and anti-nuclear antibodies spectrum were important to the diagnosis of pSS. The pSS patients had high percentage of ILD, especially small airway function abnormalities. The combination of corticosteroids and immunosuppressants appears to be effective in treatment of pSS patients with ILD. SN - 1756-185X UR - https://www.unboundmedicine.com/medline/citation/25925697/Clinical_and_laboratory_profiles_of_primary_Sjogren's_syndrome_in_a_Chinese_population:_A_retrospective_analysis_of_315_patients_ L2 - https://doi.org/10.1111/1756-185X.12583 DB - PRIME DP - Unbound Medicine ER -