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Antidiabetic and antioxidant activities of ethanolic extract of Semecarpus anacardium (Linn.) bark.
BMC Complement Altern Med. 2015 Apr 29; 15:138.BC

Abstract

BACKGROUND

Diabetes mellitus is a global health problem and constantly increasing day by day. The number of diabetic people in world is expected to rise to 366 million in 2030. The available drugs for diabetes, insulin or oral hypoglycemic agents have one or more side effects and search for new antidiabetic drugs with minimal or no side effects from medicinal plants is a challenging for us. The present study was undertaken to investigate the antidiabetic and antioxidant activity of Semecarpus anacardium (Linn.) (abbreviated as SF).

METHODS

The antidiabetic activity was determined by using alloxan-induced diabetic rats. After 15 days of treatment, serum biochemical parameters such as TC, TG, LDL, HDL, SGOT and SGPT were estimated. The survival rate, body weight, organ weight, liver glycogen and blood parameters (RBC and Hb) were also measured. The antioxidant activity was measured by DPPH free radical scavenging assay. Phytochemical screening, total phenolic and total flavonoid content were determined by using standard methods.

RESULTS

The results showed that the survival rate was 100% in rats of Group SA 400. The effect of extract on blood glucose level in Groups SA 100, SA 200 and SA 400 were dose-dependent throughout the treatment period. No significant changes in organ weight to body weight ratio were observed, liver weights significantly improved in Groups SA 200 and SA 400. The bark extract exhibited significant (p < 0.05) anti-diabetic activity with lowering TC, TG, LDL level dose-dependently and protected liver which may be partially explained by attenuation of SGOT and SGPT levels and increases liver glycogen. The percentage of Hb and RBC counts were negatively correlated with the doses of extracts. In DPPH scavenging assay, IC50 values of SA extract and ascorbic acid were found 72.24 μg/ml and 17.81 μg/ml, respectively. Phytochemical screening showed the presence of steroids, triterpenoids, flavonoids, glycosides, saponins, and tannins that were contribute to biological activity.

CONCLUSIONS

These results indicated that stem barks of S. anacardium possess strong anti-diabetic and antioxidant potentials and support traditional medicinal use for the treatment of diabetes mellitus and good source for natural antioxidants.

Authors+Show Affiliations

Department of Pharmaceutical Engineering & Drug Delivery Science, Graduate School of Integrated Pharmaceutical & Nutritional Sciences, University of Shizuoka, Shizuoka, 422-8526, Japan. ashrafali025@gmail.com. Department of Pharmacy, Mawlana Bhashani Science and Technology University, Tangail, 1902, Bangladesh. ashrafali025@gmail.com.Department of Pharmacy, University of Rajshahi, Rajshahi, 6205, Bangladesh. drmirimam@gmail.com.Department of Pharmacy, University of Rajshahi, Rajshahi, 6205, Bangladesh. nakhatun02@yahoo.com.Department of Pharmacy, University of Rajshahi, Rajshahi, 6205, Bangladesh. bmokaddes@yahoo.com.Department of Pharmacy, University of Rajshahi, Rajshahi, 6205, Bangladesh. rkb1976@gmail.com.Department of Pharmacy, Jessore University of Science and Technology, Jessore, Bangladesh. rafiqulislambd7@gmail.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25925864

Citation

Ali, Md Ashraf, et al. "Antidiabetic and Antioxidant Activities of Ethanolic Extract of Semecarpus Anacardium (Linn.) Bark." BMC Complementary and Alternative Medicine, vol. 15, 2015, p. 138.
Ali MA, Wahed MI, Khatune NA, et al. Antidiabetic and antioxidant activities of ethanolic extract of Semecarpus anacardium (Linn.) bark. BMC Complement Altern Med. 2015;15:138.
Ali, M. A., Wahed, M. I., Khatune, N. A., Rahman, B. M., Barman, R. K., & Islam, M. R. (2015). Antidiabetic and antioxidant activities of ethanolic extract of Semecarpus anacardium (Linn.) bark. BMC Complementary and Alternative Medicine, 15, 138. https://doi.org/10.1186/s12906-015-0662-z
Ali MA, et al. Antidiabetic and Antioxidant Activities of Ethanolic Extract of Semecarpus Anacardium (Linn.) Bark. BMC Complement Altern Med. 2015 Apr 29;15:138. PubMed PMID: 25925864.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antidiabetic and antioxidant activities of ethanolic extract of Semecarpus anacardium (Linn.) bark. AU - Ali,Md Ashraf, AU - Wahed,Mir Imam Ibne, AU - Khatune,Naznin Ara, AU - Rahman,Bytul Mokaddesur, AU - Barman,Ranjan Kumar, AU - Islam,Md Rafiqul, Y1 - 2015/04/29/ PY - 2014/10/23/received PY - 2015/04/22/accepted PY - 2015/5/1/entrez PY - 2015/5/1/pubmed PY - 2015/12/15/medline SP - 138 EP - 138 JF - BMC complementary and alternative medicine JO - BMC Complement Altern Med VL - 15 N2 - BACKGROUND: Diabetes mellitus is a global health problem and constantly increasing day by day. The number of diabetic people in world is expected to rise to 366 million in 2030. The available drugs for diabetes, insulin or oral hypoglycemic agents have one or more side effects and search for new antidiabetic drugs with minimal or no side effects from medicinal plants is a challenging for us. The present study was undertaken to investigate the antidiabetic and antioxidant activity of Semecarpus anacardium (Linn.) (abbreviated as SF). METHODS: The antidiabetic activity was determined by using alloxan-induced diabetic rats. After 15 days of treatment, serum biochemical parameters such as TC, TG, LDL, HDL, SGOT and SGPT were estimated. The survival rate, body weight, organ weight, liver glycogen and blood parameters (RBC and Hb) were also measured. The antioxidant activity was measured by DPPH free radical scavenging assay. Phytochemical screening, total phenolic and total flavonoid content were determined by using standard methods. RESULTS: The results showed that the survival rate was 100% in rats of Group SA 400. The effect of extract on blood glucose level in Groups SA 100, SA 200 and SA 400 were dose-dependent throughout the treatment period. No significant changes in organ weight to body weight ratio were observed, liver weights significantly improved in Groups SA 200 and SA 400. The bark extract exhibited significant (p < 0.05) anti-diabetic activity with lowering TC, TG, LDL level dose-dependently and protected liver which may be partially explained by attenuation of SGOT and SGPT levels and increases liver glycogen. The percentage of Hb and RBC counts were negatively correlated with the doses of extracts. In DPPH scavenging assay, IC50 values of SA extract and ascorbic acid were found 72.24 μg/ml and 17.81 μg/ml, respectively. Phytochemical screening showed the presence of steroids, triterpenoids, flavonoids, glycosides, saponins, and tannins that were contribute to biological activity. CONCLUSIONS: These results indicated that stem barks of S. anacardium possess strong anti-diabetic and antioxidant potentials and support traditional medicinal use for the treatment of diabetes mellitus and good source for natural antioxidants. SN - 1472-6882 UR - https://www.unboundmedicine.com/medline/citation/25925864/Antidiabetic_and_antioxidant_activities_of_ethanolic_extract_of_Semecarpus_anacardium__Linn___bark_ DB - PRIME DP - Unbound Medicine ER -