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Dietary Fat Intake Modifies the Effect of a Common Variant in the LIPC Gene on Changes in Serum Lipid Concentrations during a Long-Term Weight-Loss Intervention Trial.
J Nutr 2015; 145(6):1289-94JN

Abstract

BACKGROUND

Hepatic lipase (HL) plays a pivotal role in the metabolism of HDL and LDL. Recent genome-wide association studies have identified common variants in the HL gene (LIPC) associated with HDL cholesterol.

OBJECTIVE

We tested the effect of a common variant in LIPC on changes in blood lipids in response to weight-loss diets in the Preventing Overweight Using Novel Dietary Strategies Trial.

METHODS

We genotyped LIPC rs2070895 in 743 overweight or obese adults aged 30-70 y (61% women) who were assigned to high-fat (40% energy) or low-fat (20% energy) diets for 2 y. We measured serum concentrations of total cholesterol (TC), triglycerides, LDL cholesterol, and HDL cholesterol at baseline and 2 y of intervention.

RESULTS

At 2 y of intervention, dietary fat modified effects of the variant on changes in serum TC, LDL cholesterol, and HDL cholesterol (P-interaction: 0.0008, 0.004, and 0.03, respectively). In the low-fat group, as compared to the G allele, the A allele tended to be related to the decrease in TC and LDL cholesterol concentrations [TC (β ± SE): -5.5 ± 3.0, P = 0.07; LDL cholesterol: -4.8 ± 2.5, P = 0.06] and a lower increase in HDL cholesterol concentrations (β ± SE: -1.37 ± 0.69, P = 0.048), whereas an opposite effect in the high-fat diet group was evident [TC (β ± SE): 7.3 ± 2.7, P = 0.008; LDL cholesterol: 4.1 ± 2.3, P = 0.07], and there was no genetic effect on changes in HDL cholesterol concentrations (P = 0.54).

CONCLUSION

Dietary fat intake modifies the effect of a common variant in LIPC on changes in serum lipids during a long-term weight-loss intervention in overweight or obese adults. This trial was registered at clinicaltrials.gov as NCT00072995.

Authors+Show Affiliations

Department of Nutrition, Harvard School of Public Health, Boston, MA; Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai, China; nhlqi@channing.harvard.edu.Department of Molecular Genetics, GenoVive, New Orleans, LA;Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA;Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA;Department of Nutrition, Harvard School of Public Health, Boston, MA;Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai, China; Department of Endocrinology and Metabolism, Ruijin Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China;Department of Nutrition, Harvard School of Public Health, Boston, MA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA; and Harvard Medical School, Boston, MA nhlqi@channing.harvard.edu.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25926410

Citation

Xu, Min, et al. "Dietary Fat Intake Modifies the Effect of a Common Variant in the LIPC Gene On Changes in Serum Lipid Concentrations During a Long-Term Weight-Loss Intervention Trial." The Journal of Nutrition, vol. 145, no. 6, 2015, pp. 1289-94.
Xu M, Ng SS, Bray GA, et al. Dietary Fat Intake Modifies the Effect of a Common Variant in the LIPC Gene on Changes in Serum Lipid Concentrations during a Long-Term Weight-Loss Intervention Trial. J Nutr. 2015;145(6):1289-94.
Xu, M., Ng, S. S., Bray, G. A., Ryan, D. H., Sacks, F. M., Ning, G., & Qi, L. (2015). Dietary Fat Intake Modifies the Effect of a Common Variant in the LIPC Gene on Changes in Serum Lipid Concentrations during a Long-Term Weight-Loss Intervention Trial. The Journal of Nutrition, 145(6), pp. 1289-94. doi:10.3945/jn.115.212514.
Xu M, et al. Dietary Fat Intake Modifies the Effect of a Common Variant in the LIPC Gene On Changes in Serum Lipid Concentrations During a Long-Term Weight-Loss Intervention Trial. J Nutr. 2015;145(6):1289-94. PubMed PMID: 25926410.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary Fat Intake Modifies the Effect of a Common Variant in the LIPC Gene on Changes in Serum Lipid Concentrations during a Long-Term Weight-Loss Intervention Trial. AU - Xu,Min, AU - Ng,San San, AU - Bray,George A, AU - Ryan,Donna H, AU - Sacks,Frank M, AU - Ning,Guang, AU - Qi,Lu, Y1 - 2015/04/29/ PY - 2015/02/23/received PY - 2015/04/03/accepted PY - 2015/5/1/entrez PY - 2015/5/1/pubmed PY - 2015/8/14/medline KW - LIPC KW - gene-diet interaction KW - hepatic lipase KW - high-fat diet KW - weight-loss intervention SP - 1289 EP - 94 JF - The Journal of nutrition JO - J. Nutr. VL - 145 IS - 6 N2 - BACKGROUND: Hepatic lipase (HL) plays a pivotal role in the metabolism of HDL and LDL. Recent genome-wide association studies have identified common variants in the HL gene (LIPC) associated with HDL cholesterol. OBJECTIVE: We tested the effect of a common variant in LIPC on changes in blood lipids in response to weight-loss diets in the Preventing Overweight Using Novel Dietary Strategies Trial. METHODS: We genotyped LIPC rs2070895 in 743 overweight or obese adults aged 30-70 y (61% women) who were assigned to high-fat (40% energy) or low-fat (20% energy) diets for 2 y. We measured serum concentrations of total cholesterol (TC), triglycerides, LDL cholesterol, and HDL cholesterol at baseline and 2 y of intervention. RESULTS: At 2 y of intervention, dietary fat modified effects of the variant on changes in serum TC, LDL cholesterol, and HDL cholesterol (P-interaction: 0.0008, 0.004, and 0.03, respectively). In the low-fat group, as compared to the G allele, the A allele tended to be related to the decrease in TC and LDL cholesterol concentrations [TC (β ± SE): -5.5 ± 3.0, P = 0.07; LDL cholesterol: -4.8 ± 2.5, P = 0.06] and a lower increase in HDL cholesterol concentrations (β ± SE: -1.37 ± 0.69, P = 0.048), whereas an opposite effect in the high-fat diet group was evident [TC (β ± SE): 7.3 ± 2.7, P = 0.008; LDL cholesterol: 4.1 ± 2.3, P = 0.07], and there was no genetic effect on changes in HDL cholesterol concentrations (P = 0.54). CONCLUSION: Dietary fat intake modifies the effect of a common variant in LIPC on changes in serum lipids during a long-term weight-loss intervention in overweight or obese adults. This trial was registered at clinicaltrials.gov as NCT00072995. SN - 1541-6100 UR - https://www.unboundmedicine.com/medline/citation/25926410/Dietary_Fat_Intake_Modifies_the_Effect_of_a_Common_Variant_in_the_LIPC_Gene_on_Changes_in_Serum_Lipid_Concentrations_during_a_Long_Term_Weight_Loss_Intervention_Trial_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.3945/jn.115.212514 DB - PRIME DP - Unbound Medicine ER -