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Skeletal muscle depletion predicts the prognosis of patients with hepatocellular carcinoma treated with sorafenib.
Int J Mol Sci 2015; 16(5):9612-24IJ

Abstract

The aim of this study was to determine whether skeletal muscle depletion predicts the prognosis of patients with hepatocellular carcinoma (HCC) that is being treated with sorafenib. We evaluated 40 consecutive HCC patients who received sorafenib treatment. The skeletal muscle cross-sectional area was measured by computed tomography at the third lumbar vertebra (L3), from which the L3 skeletal muscle index (L3 SMI) was obtained. The factors contributing to overall survival, sorafenib dose reduction, and discontinuation of sorafenib were analyzed using the Cox proportional hazards model. L3 SMI (p = 0.020) and log (α-fetoprotein (AFP)) (p = 0.010) were identified as independent prognostic factors in HCC patients treated with sorafenib. The initial dose of sorafenib (p = 0.008) was an independent risk factor for sorafenib dose reduction, and log (AFP) (p = 0.008) was the only significant risk factor for the discontinuation of this drug. L3 SMI was not a risk factor for either dose reduction (p = 0.423) or the discontinuation (p = 0.132) of sorafenib. A multiple linear regression analysis determined the following relationship between skeletal muscle mass (assessed as L3 SMI) and the explanatory factors: L3 SMI = -0.1896 × (Age) - 10.3441 × (Child-Pugh score) - 9.3922 × (log (AFP)) + 1.6139 × (log (AFP)) × (Child-Pugh score) + 112.9166. Skeletal muscle depletion is inversely associated with age, Child-Pugh score, and log (AFP). Moreover, it is an independent prognostic factor for HCC patients treated with sorafenib.

Authors+Show Affiliations

Department of Gastroenterology/Internal Medicine, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan. ikenji@gifu-u.ac.jp.Department of Gastroenterology/Internal Medicine, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan. koz@gifu-u.ac.jp.Department of Gastroenterology/Internal Medicine, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan. hanai0606@yahoo.co.jp.Department of Gastroenterology/Internal Medicine, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan. taka.mailbox.789@gmail.com.Department of Gastroenterology/Internal Medicine, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan. tsunemiyazaking@yahoo.co.jp.Department of Gastroenterology/Internal Medicine, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan. kottii924@gmail.com.Department of Gastroenterology/Internal Medicine, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan. asue327@yahoo.co.jp.Department of Gastroenterology/Internal Medicine, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan. mshiraki-gif@umin.ac.jp.Department of Gastroenterology/Internal Medicine, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan. mshiraki-gif@umin.ac.jp.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25927582

Citation

Imai, Kenji, et al. "Skeletal Muscle Depletion Predicts the Prognosis of Patients With Hepatocellular Carcinoma Treated With Sorafenib." International Journal of Molecular Sciences, vol. 16, no. 5, 2015, pp. 9612-24.
Imai K, Takai K, Hanai T, et al. Skeletal muscle depletion predicts the prognosis of patients with hepatocellular carcinoma treated with sorafenib. Int J Mol Sci. 2015;16(5):9612-24.
Imai, K., Takai, K., Hanai, T., Ideta, T., Miyazaki, T., Kochi, T., ... Shimizu, M. (2015). Skeletal muscle depletion predicts the prognosis of patients with hepatocellular carcinoma treated with sorafenib. International Journal of Molecular Sciences, 16(5), pp. 9612-24. doi:10.3390/ijms16059612.
Imai K, et al. Skeletal Muscle Depletion Predicts the Prognosis of Patients With Hepatocellular Carcinoma Treated With Sorafenib. Int J Mol Sci. 2015 Apr 28;16(5):9612-24. PubMed PMID: 25927582.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Skeletal muscle depletion predicts the prognosis of patients with hepatocellular carcinoma treated with sorafenib. AU - Imai,Kenji, AU - Takai,Koji, AU - Hanai,Tatsunori, AU - Ideta,Takayasu, AU - Miyazaki,Tsuneyuki, AU - Kochi,Takahiro, AU - Suetsugu,Atsushi, AU - Shiraki,Makoto, AU - Shimizu,Masahito, Y1 - 2015/04/28/ PY - 2015/02/03/received PY - 2015/04/18/revised PY - 2015/04/22/accepted PY - 2015/5/1/entrez PY - 2015/5/1/pubmed PY - 2016/1/19/medline SP - 9612 EP - 24 JF - International journal of molecular sciences JO - Int J Mol Sci VL - 16 IS - 5 N2 - The aim of this study was to determine whether skeletal muscle depletion predicts the prognosis of patients with hepatocellular carcinoma (HCC) that is being treated with sorafenib. We evaluated 40 consecutive HCC patients who received sorafenib treatment. The skeletal muscle cross-sectional area was measured by computed tomography at the third lumbar vertebra (L3), from which the L3 skeletal muscle index (L3 SMI) was obtained. The factors contributing to overall survival, sorafenib dose reduction, and discontinuation of sorafenib were analyzed using the Cox proportional hazards model. L3 SMI (p = 0.020) and log (α-fetoprotein (AFP)) (p = 0.010) were identified as independent prognostic factors in HCC patients treated with sorafenib. The initial dose of sorafenib (p = 0.008) was an independent risk factor for sorafenib dose reduction, and log (AFP) (p = 0.008) was the only significant risk factor for the discontinuation of this drug. L3 SMI was not a risk factor for either dose reduction (p = 0.423) or the discontinuation (p = 0.132) of sorafenib. A multiple linear regression analysis determined the following relationship between skeletal muscle mass (assessed as L3 SMI) and the explanatory factors: L3 SMI = -0.1896 × (Age) - 10.3441 × (Child-Pugh score) - 9.3922 × (log (AFP)) + 1.6139 × (log (AFP)) × (Child-Pugh score) + 112.9166. Skeletal muscle depletion is inversely associated with age, Child-Pugh score, and log (AFP). Moreover, it is an independent prognostic factor for HCC patients treated with sorafenib. SN - 1422-0067 UR - https://www.unboundmedicine.com/medline/citation/25927582/Skeletal_muscle_depletion_predicts_the_prognosis_of_patients_with_hepatocellular_carcinoma_treated_with_sorafenib_ L2 - http://www.mdpi.com/resolver?pii=ijms16059612 DB - PRIME DP - Unbound Medicine ER -