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Imatinib-induced Severe Hepatitis in a 9-Year-old Girl With Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia.
J Pediatr Hematol Oncol. 2015 Aug; 37(6):e368-71.JP

Abstract

Imatinib mesylate has dramatically improved the outcome of children with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph* ALL) and is now included as first-line therapy. Uncommon adverse effects of this drug for pediatric use, however, are largely unknown. We report the first case of a 9-year-old child who developed severe acute hepatitis with grade 4 transaminases and bilirubin elevation during imatinib treatment for Ph* ALL. Liver biopsy showed extensive lobular and pericentral necrosis of hepatocytes. Liver function recovered after discontinuing imatinib with a 4-week prednisolone. Extensive hepatic necrosis should be considered not only in adults but also in children under imatinib administration.

Authors+Show Affiliations

*Department of Child Health, Graduate School of Comprehensive Human Sciences, University of Tsukuba Departments of †Child Health ‡Pathology, Faculty of Medicine §Clinical Laboratory, University of Tsukuba Hospital, Tsukuba, Ibaraki, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

25929609

Citation

Suzuki, Ryoko, et al. "Imatinib-induced Severe Hepatitis in a 9-Year-old Girl With Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia." Journal of Pediatric Hematology/oncology, vol. 37, no. 6, 2015, pp. e368-71.
Suzuki R, Kobayashi C, Sakai A, et al. Imatinib-induced Severe Hepatitis in a 9-Year-old Girl With Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia. J Pediatr Hematol Oncol. 2015;37(6):e368-71.
Suzuki, R., Kobayashi, C., Sakai, A., Fukushima, H., Tagawa, M., Satomi, K., Nanmoku, T., Sumazaki, R., & Fukushima, T. (2015). Imatinib-induced Severe Hepatitis in a 9-Year-old Girl With Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia. Journal of Pediatric Hematology/oncology, 37(6), e368-71. https://doi.org/10.1097/MPH.0000000000000337
Suzuki R, et al. Imatinib-induced Severe Hepatitis in a 9-Year-old Girl With Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia. J Pediatr Hematol Oncol. 2015;37(6):e368-71. PubMed PMID: 25929609.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Imatinib-induced Severe Hepatitis in a 9-Year-old Girl With Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia. AU - Suzuki,Ryoko, AU - Kobayashi,Chie, AU - Sakai,Aiko, AU - Fukushima,Hiroko, AU - Tagawa,Manabu, AU - Satomi,Kaishi, AU - Nanmoku,Toru, AU - Sumazaki,Ryo, AU - Fukushima,Takashi, PY - 2015/5/2/entrez PY - 2015/5/2/pubmed PY - 2015/10/16/medline SP - e368 EP - 71 JF - Journal of pediatric hematology/oncology JO - J Pediatr Hematol Oncol VL - 37 IS - 6 N2 - Imatinib mesylate has dramatically improved the outcome of children with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph* ALL) and is now included as first-line therapy. Uncommon adverse effects of this drug for pediatric use, however, are largely unknown. We report the first case of a 9-year-old child who developed severe acute hepatitis with grade 4 transaminases and bilirubin elevation during imatinib treatment for Ph* ALL. Liver biopsy showed extensive lobular and pericentral necrosis of hepatocytes. Liver function recovered after discontinuing imatinib with a 4-week prednisolone. Extensive hepatic necrosis should be considered not only in adults but also in children under imatinib administration. SN - 1536-3678 UR - https://www.unboundmedicine.com/medline/citation/25929609/Imatinib_induced_Severe_Hepatitis_in_a_9_Year_old_Girl_With_Philadelphia_Chromosome_positive_Acute_Lymphoblastic_Leukemia_ L2 - https://doi.org/10.1097/MPH.0000000000000337 DB - PRIME DP - Unbound Medicine ER -