Tags

Type your tag names separated by a space and hit enter

The effect of processing variables on the mechanical and release properties of tramadol matrix tablets incorporating Cissus populnea gum as controlled release excipient.
Polim Med. 2014 Oct-Dec; 44(4):209-20.PM

Abstract

BACKGROUND

Natural gums are polymers widely used as excipients in drug formulation. Polymer extraction and formulation processing methods could significantly affect formulation characteristics.

OBJECTIVES

To evaluate different methods of gum extraction and the effect of different compression methods on the mechanical and release properties of tramadol hydrochloride matrix tablets incorporating cissus gum as controlled release polymer.

MATERIAL AND METHODS

Water (CW) and acetone (CA) extracts of cissus gum were obtained from Cissus populea stem and two methods - wet granulation and direct compression - were used to compress the tablet and compare it with xanthan gum (X) formulations. Crushing strength and friability were used to assess mechanical properties while dissolution rate were used to assess release properties. Data were analysed using t-test and ANOVA at p < 0.05.

RESULTS

The crushing strength of tramadol tablets has increased together with the increase in polymer concentration in all formulations, while friability has decreased for both methods. Tablets made by wet granulation had higher crushing strength than those made by direct compression method. The release mechanism for both direct compression and wet granulation methods was Fickian and non-Fickian respectively. The rank order for t25, t50 and t75 for all formulations was X > CA > CW. Generally, wet granulation method decreased the rate of tramadol release more than direct compression method, indicating a higher drug retarding ability.

CONCLUSIONS

Incorporation of cissus gum controlled the release of tramadol hydrochloride from the matrix tablets. Extraction method and formulation variables influenced mechanical and release properties of the tablets. Cissus gum acetone extract had comparable release properties with xanthan gum and could serve as a cheaper alternative in controlled release tablet formulations.

Authors+Show Affiliations

Adeleye OA
Department of Pharmaceutics and Pharmaceutical Technology, Olabisi Onabanjo University, Ago-Iwoye, Ogun State, Nigeria.
Femi-Oyewo MN
Department of Pharmaceutics and Pharmaceutical Technology, Olabisi Onabanjo University, Ago-Iwoye, Ogun State, Nigeria.
Odeniyi MA
Department of Pharmaceutics and Industrial Pharmacy, University of Ibadan, Ibadan, Oyo State, Nigeria.

MeSH

Administration, OralAnalgesics, OpioidAnalysis of VarianceChemistry, PharmaceuticalCissusDelayed-Action PreparationsExcipientsPlant ExtractsPlant GumsSolubilityTabletsTramadol

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25932902

Citation

Adeleye, Olutayo Ademola, et al. "The Effect of Processing Variables On the Mechanical and Release Properties of Tramadol Matrix Tablets Incorporating Cissus Populnea Gum as Controlled Release Excipient." Polimery W Medycynie, vol. 44, no. 4, 2014, pp. 209-20.
Adeleye OA, Femi-Oyewo MN, Odeniyi MA. The effect of processing variables on the mechanical and release properties of tramadol matrix tablets incorporating Cissus populnea gum as controlled release excipient. Polim Med. 2014;44(4):209-20.
Adeleye, O. A., Femi-Oyewo, M. N., & Odeniyi, M. A. (2014). The effect of processing variables on the mechanical and release properties of tramadol matrix tablets incorporating Cissus populnea gum as controlled release excipient. Polimery W Medycynie, 44(4), 209-20.
Adeleye OA, Femi-Oyewo MN, Odeniyi MA. The Effect of Processing Variables On the Mechanical and Release Properties of Tramadol Matrix Tablets Incorporating Cissus Populnea Gum as Controlled Release Excipient. Polim Med. 2014 Oct-Dec;44(4):209-20. PubMed PMID: 25932902.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of processing variables on the mechanical and release properties of tramadol matrix tablets incorporating Cissus populnea gum as controlled release excipient. AU - Adeleye,Olutayo Ademola, AU - Femi-Oyewo,Mbang Nyong, AU - Odeniyi,Michael Ayodele, PY - 2015/5/2/entrez PY - 2015/5/2/pubmed PY - 2015/6/13/medline SP - 209 EP - 20 JF - Polimery w medycynie JO - Polim Med VL - 44 IS - 4 N2 - BACKGROUND: Natural gums are polymers widely used as excipients in drug formulation. Polymer extraction and formulation processing methods could significantly affect formulation characteristics. OBJECTIVES: To evaluate different methods of gum extraction and the effect of different compression methods on the mechanical and release properties of tramadol hydrochloride matrix tablets incorporating cissus gum as controlled release polymer. MATERIAL AND METHODS: Water (CW) and acetone (CA) extracts of cissus gum were obtained from Cissus populea stem and two methods - wet granulation and direct compression - were used to compress the tablet and compare it with xanthan gum (X) formulations. Crushing strength and friability were used to assess mechanical properties while dissolution rate were used to assess release properties. Data were analysed using t-test and ANOVA at p < 0.05. RESULTS: The crushing strength of tramadol tablets has increased together with the increase in polymer concentration in all formulations, while friability has decreased for both methods. Tablets made by wet granulation had higher crushing strength than those made by direct compression method. The release mechanism for both direct compression and wet granulation methods was Fickian and non-Fickian respectively. The rank order for t25, t50 and t75 for all formulations was X > CA > CW. Generally, wet granulation method decreased the rate of tramadol release more than direct compression method, indicating a higher drug retarding ability. CONCLUSIONS: Incorporation of cissus gum controlled the release of tramadol hydrochloride from the matrix tablets. Extraction method and formulation variables influenced mechanical and release properties of the tablets. Cissus gum acetone extract had comparable release properties with xanthan gum and could serve as a cheaper alternative in controlled release tablet formulations. SN - 0370-0747 UR - https://www.unboundmedicine.com/medline/citation/25932902/The_effect_of_processing_variables_on_the_mechanical_and_release_properties_of_tramadol_matrix_tablets_incorporating_Cissus_populnea_gum_as_controlled_release_excipient_ DB - PRIME DP - Unbound Medicine ER -