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Supplementation of α-linolenic acid improves serum adiponectin levels and insulin sensitivity in patients with type 2 diabetes.
Nutrition 2015; 31(6):853-7N

Abstract

OBJECTIVE

ω-3 Polyunsaturated α-linolenic acid (ALA) supplementation has not been studied in the setting of adiponectin levels and insulin sensitivity (IS) improvements in patients with type 2 diabetes mellitus (T2DM) by hyperinsulinemic-euglycemic clamp (HEC). The aim of this study was to examine the influence of ω-3 ALA on IS and adiponectin.

METHODS

We conducted a randomized study in patients with T2DM and assessed IS using HEC. Twenty patients with T2DM were included and randomly assigned to receive 3 g/d of ALA or placebo for 60 d, in a double-blind design. The assessment of IS by HEC was performed at baseline and after 60 d in all patients; blood samples were taken for the measurement of serum lipids, glucose, insulin, adiponectin, and cytokines. The primary outcome variables were an increase of both glucose infusion rate (GIR) in steady state and glucose metabolization (M) by HEC. The secondary outcomes were an increase in adiponectin levels and a decrease in fasting plasma glucose, glycated hemoglobin, homeostasis model assessment-estimated insulin resistance (HOMA-IR) index, lipids and cytokines. The study was conducted at an academic medical center.

RESULTS

The ALA group improved IS corrected for fat-free mass (M/FFM; P = 0.04). Both groups showed increased adiponectin after 60 d (P = 0.01), however, the increase for the ALA group was greater (P = 0.04). In the ALA group, adiponectin was positively correlated with GIR (r = 0.76; P = 0.01) and M/FFM (r = 0.62; P = 0.06), and negatively correlated with HOMA-IR (r = -0.61; P = 0.03).

CONCLUSION

ω-3 ALA supplementation improved glucose homeostasis and was associated with an increase in adiponectin. Improvement in the overall metabolic profile with ω-3 ALA suggests a potential clinical utility for this agent and requires further investigation.

Authors+Show Affiliations

Division of Endocrinology and Metabolism, Department of Medicine, School of Medicine of Ribeirao Preto, University of Sao Paulo, Sao Paulo, Brazil. Electronic address: Dra.patricia.moreira@gmail.com.Division of Endocrinology and Metabolism, Department of Medicine, School of Medicine of Ribeirao Preto, University of Sao Paulo, Sao Paulo, Brazil.Division of Endocrinology and Metabolism, Department of Medicine, School of Medicine of Ribeirao Preto, University of Sao Paulo, Sao Paulo, Brazil.Division of Endocrinology and Metabolism, Department of Medicine, School of Medicine of Ribeirao Preto, University of Sao Paulo, Sao Paulo, Brazil.Laboratory of Investigation on Metabolism and Diabetes, University of Campinas, Sao Paulo, Brazil.Division of Endocrinology and Metabolism, Department of Medicine, School of Medicine of Ribeirao Preto, University of Sao Paulo, Sao Paulo, Brazil.Division of Endocrinology and Metabolism, Department of Medicine, School of Medicine of Ribeirao Preto, University of Sao Paulo, Sao Paulo, Brazil.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25933493

Citation

Gomes, Patricia M., et al. "Supplementation of Α-linolenic Acid Improves Serum Adiponectin Levels and Insulin Sensitivity in Patients With Type 2 Diabetes." Nutrition (Burbank, Los Angeles County, Calif.), vol. 31, no. 6, 2015, pp. 853-7.
Gomes PM, Hollanda-Miranda WR, Beraldo RA, et al. Supplementation of α-linolenic acid improves serum adiponectin levels and insulin sensitivity in patients with type 2 diabetes. Nutrition. 2015;31(6):853-7.
Gomes, P. M., Hollanda-Miranda, W. R., Beraldo, R. A., Castro, A. V., Geloneze, B., Foss, M. C., & Foss-Freitas, M. C. (2015). Supplementation of α-linolenic acid improves serum adiponectin levels and insulin sensitivity in patients with type 2 diabetes. Nutrition (Burbank, Los Angeles County, Calif.), 31(6), pp. 853-7. doi:10.1016/j.nut.2014.12.028.
Gomes PM, et al. Supplementation of Α-linolenic Acid Improves Serum Adiponectin Levels and Insulin Sensitivity in Patients With Type 2 Diabetes. Nutrition. 2015;31(6):853-7. PubMed PMID: 25933493.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Supplementation of α-linolenic acid improves serum adiponectin levels and insulin sensitivity in patients with type 2 diabetes. AU - Gomes,Patricia M, AU - Hollanda-Miranda,Wallace R, AU - Beraldo,Rebeca A, AU - Castro,Ana V B, AU - Geloneze,Bruno, AU - Foss,Milton C, AU - Foss-Freitas,Maria C, Y1 - 2015/02/21/ PY - 2014/07/03/received PY - 2014/11/10/revised PY - 2014/12/20/accepted PY - 2015/5/3/entrez PY - 2015/5/3/pubmed PY - 2016/1/27/medline KW - Adiponectin KW - Hyperinsulinemic-euglycemic clamp KW - Insulin resistance KW - Type 2 diabetes mellitus KW - α-Linolenic acid SP - 853 EP - 7 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 31 IS - 6 N2 - OBJECTIVE: ω-3 Polyunsaturated α-linolenic acid (ALA) supplementation has not been studied in the setting of adiponectin levels and insulin sensitivity (IS) improvements in patients with type 2 diabetes mellitus (T2DM) by hyperinsulinemic-euglycemic clamp (HEC). The aim of this study was to examine the influence of ω-3 ALA on IS and adiponectin. METHODS: We conducted a randomized study in patients with T2DM and assessed IS using HEC. Twenty patients with T2DM were included and randomly assigned to receive 3 g/d of ALA or placebo for 60 d, in a double-blind design. The assessment of IS by HEC was performed at baseline and after 60 d in all patients; blood samples were taken for the measurement of serum lipids, glucose, insulin, adiponectin, and cytokines. The primary outcome variables were an increase of both glucose infusion rate (GIR) in steady state and glucose metabolization (M) by HEC. The secondary outcomes were an increase in adiponectin levels and a decrease in fasting plasma glucose, glycated hemoglobin, homeostasis model assessment-estimated insulin resistance (HOMA-IR) index, lipids and cytokines. The study was conducted at an academic medical center. RESULTS: The ALA group improved IS corrected for fat-free mass (M/FFM; P = 0.04). Both groups showed increased adiponectin after 60 d (P = 0.01), however, the increase for the ALA group was greater (P = 0.04). In the ALA group, adiponectin was positively correlated with GIR (r = 0.76; P = 0.01) and M/FFM (r = 0.62; P = 0.06), and negatively correlated with HOMA-IR (r = -0.61; P = 0.03). CONCLUSION: ω-3 ALA supplementation improved glucose homeostasis and was associated with an increase in adiponectin. Improvement in the overall metabolic profile with ω-3 ALA suggests a potential clinical utility for this agent and requires further investigation. SN - 1873-1244 UR - https://www.unboundmedicine.com/medline/citation/25933493/Supplementation_of_α_linolenic_acid_improves_serum_adiponectin_levels_and_insulin_sensitivity_in_patients_with_type_2_diabetes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(15)00040-4 DB - PRIME DP - Unbound Medicine ER -