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Postprandial adiponectin and gelatinase response to a high-fat versus an isoenergetic low-fat meal in lean, healthy men.
Nutrition 2015; 31(6):863-70N

Abstract

OBJECTIVE

Evidence suggests that an acute systemic inflammatory response is invoked after consumption of a high-energy meal. Postprandial regulation of adiponectin, an adipose tissue-derived, anti-inflammatory hormone, and the gelatinases, matrix metalloproteinase (MMP)-2 and MMP-9, endopeptidases implicated in a diverse range of inflammatory processes, remain inconclusive. The aim of this study was to assess the postprandial effect of a high-energy (1212 kcal) meal on plasma adiponectin, MMP-2 and MMP-9 activity, glucose, insulin, triacylglycerols, total cholesterol, high-density lipoprotein cholesterol, and the differential effects on these parameters depending on whether the test meal was high fat (HF; 46 g fat, 1210 kcal) or isoenergetic and low fat (LF; 15 g fat, 1214 kcal energy).

METHODS

Test meals were consumed by 17 lean, healthy men on two separate occasions with blood samples collected by venipuncture at baseline (0 h) and 1 and 3 h after consumption of each test meal.

RESULTS

At baseline, no significant difference was seen in the parameters between the two groups, except for MMP-2, MMP-9, and total cholesterol. Over the 3-h postprandial period, no significant differential effect of the HF versus the LF test meal was observed on adiponectin, MMP-2, MMP-9, or on metabolic markers other than triacylglycerol, which increased significantly in response to the HF test meal (time × treatment, P = 0.002). When analyzed independent of time, MMP-2 (treatment, P = 0.006), MMP-9 (treatment, P = 0.022), and glucose (treatment, P = 0.026) were lower after consumption of the HF meal compared with the LF test meal. When analyzed independent of treatment, adiponectin increased over the 3-h postprandial period (time, P = 0.031), but there was no change in MMP-2 or MMP-9 (time, P = 0.503 and P = 0.525, respectively). Over the 3-h postprandial period, insulin (time, P < 0.001) and total cholesterol (time, P = 0.002) increased, whereas glucose (time, P < 0.001) and high-density lipoprotein cholesterol (time, P < 0.001) decreased.

CONCLUSION

No differential effects of a HF versus a LF isoenergetic meal were seen on postprandial adiponectin or the gelatinases. Adiponectin increased in response to a high-energy meal independent of treatment, and the gelatinases were lower in response to the HF versus the LF isoenergetic meal, independent of time point. Given the considerable amount of time that humans spend in the postprandial state, additional research is necessary to further understand inflammatory changes in this state.

Authors+Show Affiliations

Department of Pharmacology and Therapeutics, Trinity College Dublin, Dublin, Ireland. Electronic address: Alan.kennedy@tcd.ie.Department of Pharmacology and Therapeutics, Trinity College Dublin, Dublin, Ireland.Department of Biochemistry, St James' Hospital, Dublin, Ireland.Statistical Consulting Unit, The Australian National University, Canberra, Australia.Nutrition and Dietetics, Faculty of Health, University of Canberra, Canberra, Australia.

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

25933495

Citation

Kennedy, Alan, et al. "Postprandial Adiponectin and Gelatinase Response to a High-fat Versus an Isoenergetic Low-fat Meal in Lean, Healthy Men." Nutrition (Burbank, Los Angeles County, Calif.), vol. 31, no. 6, 2015, pp. 863-70.
Kennedy A, Spiers JP, Crowley V, et al. Postprandial adiponectin and gelatinase response to a high-fat versus an isoenergetic low-fat meal in lean, healthy men. Nutrition. 2015;31(6):863-70.
Kennedy, A., Spiers, J. P., Crowley, V., Williams, E., & Lithander, F. E. (2015). Postprandial adiponectin and gelatinase response to a high-fat versus an isoenergetic low-fat meal in lean, healthy men. Nutrition (Burbank, Los Angeles County, Calif.), 31(6), pp. 863-70. doi:10.1016/j.nut.2015.01.009.
Kennedy A, et al. Postprandial Adiponectin and Gelatinase Response to a High-fat Versus an Isoenergetic Low-fat Meal in Lean, Healthy Men. Nutrition. 2015;31(6):863-70. PubMed PMID: 25933495.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Postprandial adiponectin and gelatinase response to a high-fat versus an isoenergetic low-fat meal in lean, healthy men. AU - Kennedy,Alan, AU - Spiers,J Paul, AU - Crowley,Vivion, AU - Williams,Emlyn, AU - Lithander,Fiona E, Y1 - 2015/02/26/ PY - 2014/08/20/received PY - 2015/01/21/revised PY - 2015/01/21/accepted PY - 2015/5/3/entrez PY - 2015/5/3/pubmed PY - 2016/1/27/medline KW - Adiponectin KW - High-fat KW - Low-fat KW - MMP-2 KW - MMP-9 KW - Postprandial SP - 863 EP - 70 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 31 IS - 6 N2 - OBJECTIVE: Evidence suggests that an acute systemic inflammatory response is invoked after consumption of a high-energy meal. Postprandial regulation of adiponectin, an adipose tissue-derived, anti-inflammatory hormone, and the gelatinases, matrix metalloproteinase (MMP)-2 and MMP-9, endopeptidases implicated in a diverse range of inflammatory processes, remain inconclusive. The aim of this study was to assess the postprandial effect of a high-energy (1212 kcal) meal on plasma adiponectin, MMP-2 and MMP-9 activity, glucose, insulin, triacylglycerols, total cholesterol, high-density lipoprotein cholesterol, and the differential effects on these parameters depending on whether the test meal was high fat (HF; 46 g fat, 1210 kcal) or isoenergetic and low fat (LF; 15 g fat, 1214 kcal energy). METHODS: Test meals were consumed by 17 lean, healthy men on two separate occasions with blood samples collected by venipuncture at baseline (0 h) and 1 and 3 h after consumption of each test meal. RESULTS: At baseline, no significant difference was seen in the parameters between the two groups, except for MMP-2, MMP-9, and total cholesterol. Over the 3-h postprandial period, no significant differential effect of the HF versus the LF test meal was observed on adiponectin, MMP-2, MMP-9, or on metabolic markers other than triacylglycerol, which increased significantly in response to the HF test meal (time × treatment, P = 0.002). When analyzed independent of time, MMP-2 (treatment, P = 0.006), MMP-9 (treatment, P = 0.022), and glucose (treatment, P = 0.026) were lower after consumption of the HF meal compared with the LF test meal. When analyzed independent of treatment, adiponectin increased over the 3-h postprandial period (time, P = 0.031), but there was no change in MMP-2 or MMP-9 (time, P = 0.503 and P = 0.525, respectively). Over the 3-h postprandial period, insulin (time, P < 0.001) and total cholesterol (time, P = 0.002) increased, whereas glucose (time, P < 0.001) and high-density lipoprotein cholesterol (time, P < 0.001) decreased. CONCLUSION: No differential effects of a HF versus a LF isoenergetic meal were seen on postprandial adiponectin or the gelatinases. Adiponectin increased in response to a high-energy meal independent of treatment, and the gelatinases were lower in response to the HF versus the LF isoenergetic meal, independent of time point. Given the considerable amount of time that humans spend in the postprandial state, additional research is necessary to further understand inflammatory changes in this state. SN - 1873-1244 UR - https://www.unboundmedicine.com/medline/citation/25933495/Postprandial_adiponectin_and_gelatinase_response_to_a_high_fat_versus_an_isoenergetic_low_fat_meal_in_lean_healthy_men_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(15)00076-3 DB - PRIME DP - Unbound Medicine ER -