Citation
Kalish, Brian T., et al. "Dietary Ω-3 Fatty Acids Protect Against Vasculopathy in a Transgenic Mouse Model of Sickle Cell Disease." Haematologica, vol. 100, no. 7, 2015, pp. 870-80.
Kalish BT, Matte A, Andolfo I, et al. Dietary ω-3 fatty acids protect against vasculopathy in a transgenic mouse model of sickle cell disease. Haematologica. 2015;100(7):870-80.
Kalish, B. T., Matte, A., Andolfo, I., Iolascon, A., Weinberg, O., Ghigo, A., Cimino, J., Siciliano, A., Hirsch, E., Federti, E., Puder, M., Brugnara, C., & De Franceschi, L. (2015). Dietary ω-3 fatty acids protect against vasculopathy in a transgenic mouse model of sickle cell disease. Haematologica, 100(7), 870-80. https://doi.org/10.3324/haematol.2015.124586
Kalish BT, et al. Dietary Ω-3 Fatty Acids Protect Against Vasculopathy in a Transgenic Mouse Model of Sickle Cell Disease. Haematologica. 2015;100(7):870-80. PubMed PMID: 25934765.
TY - JOUR
T1 - Dietary ω-3 fatty acids protect against vasculopathy in a transgenic mouse model of sickle cell disease.
AU - Kalish,Brian T,
AU - Matte,Alessandro,
AU - Andolfo,Immacolata,
AU - Iolascon,Achille,
AU - Weinberg,Olga,
AU - Ghigo,Alessandra,
AU - Cimino,James,
AU - Siciliano,Angela,
AU - Hirsch,Emilio,
AU - Federti,Enrica,
AU - Puder,Mark,
AU - Brugnara,Carlo,
AU - De Franceschi,Lucia,
Y1 - 2015/05/01/
PY - 2015/02/02/received
PY - 2015/04/27/accepted
PY - 2015/5/3/entrez
PY - 2015/5/3/pubmed
PY - 2016/2/10/medline
SP - 870
EP - 80
JF - Haematologica
JO - Haematologica
VL - 100
IS - 7
N2 - The anemia of sickle cell disease is associated with a severe inflammatory vasculopathy and endothelial dysfunction, which leads to painful and life-threatening clinical complications. Growing evidence supports the anti-inflammatory properties of ω-3 fatty acids in clinical models of endothelial dysfunction. Promising but limited studies show potential therapeutic effects of ω-3 fatty acid supplementation in sickle cell disease. Here, we treated humanized healthy and sickle cell mice for 6 weeks with ω-3 fatty acid diet (fish-oil diet). We found that a ω-3 fatty acid diet: (i) normalizes red cell membrane ω-6/ω-3 ratio; (ii) reduces neutrophil count; (iii) decreases endothelial activation by targeting endothelin-1 and (iv) improves left ventricular outflow tract dimensions. In a hypoxia-reoxygenation model of acute vaso-occlusive crisis, a ω-3 fatty acid diet reduced systemic and local inflammation and protected against sickle cell-related end-organ injury. Using isolated aortas from sickle cell mice exposed to hypoxia-reoxygenation, we demonstrated a direct impact of a ω-3 fatty acid diet on vascular activation, inflammation, and anti-oxidant systems. Our data provide the rationale for ω-3 dietary supplementation as a therapeutic intervention to reduce vascular dysfunction in sickle cell disease.
SN - 1592-8721
UR - https://www.unboundmedicine.com/medline/citation/25934765/Dietary_ω_3_fatty_acids_protect_against_vasculopathy_in_a_transgenic_mouse_model_of_sickle_cell_disease_
DB - PRIME
DP - Unbound Medicine
ER -