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Hematinic deficiencies and pernicious anemia in oral mucosal disease patients with macrocytosis.
J Formos Med Assoc. 2015 Aug; 114(8):736-41.JF

Abstract

BACKGROUND/PURPOSE

Macrocytosis is defined as having the mean corpuscular volume (MCV) ≥ 100 fL. This study assessed hematinic deficiencies and pernicious anemia (PA) in oral mucosal disease patients with macrocytosis.

METHODS

The blood hemoglobin (Hb), iron, vitamin B12, folic acid, and homocysteine concentrations and MCV in 60 oral mucosal disease patients with macrocytosis were measured and compared with the corresponding data in 120 age- and sex-matched healthy control participants. PA was defined by the World Health Organization (WHO) as having an Hb concentration < 13 g/dL for men and < 12 g/dL for women, an MCV ≥ 100 fL, a serum vitamin B12 level < 200 pg/mL, and serum gastric parietal cell antibody (GPCA) positivity.

RESULTS

We found that 30 (50.0%), 7 (11.7%), 24 (40.0%), and three (5.0%) oral mucosal disease patients with macrocytosis had deficiencies of Hb (men < 13 g/dL, women < 12 g/dL), iron (< 60 μg/dL), vitamin B12 (< 200 pg/mL), and folic acid (< 4 mg/mL), respectively. Moreover, 38 (63.3%) and 16 (26.7%) macrocytosis patients had abnormally high blood homocysteine level (> 12.3 μM) and serum GPCA positivity, respectively. Macrocytosis patients had a significantly higher frequency of Hb, iron, or vitamin B12 deficiency, of abnormally elevated blood homocysteine level, and of GPCA positivity than healthy control participants (p < 0.001). However, only 16.7% of 60 macrocytosis patients were diagnosed as having PA by the WHO definition.

CONCLUSION

Only 16.7% of oral mucosal disease patients with macrocytosis are discovered to have PA by the WHO definition.

Authors+Show Affiliations

Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan.Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address: andysun7702@yahoo.com.tw.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25935499

Citation

Chang, Julia Yu-Fong, et al. "Hematinic Deficiencies and Pernicious Anemia in Oral Mucosal Disease Patients With Macrocytosis." Journal of the Formosan Medical Association = Taiwan Yi Zhi, vol. 114, no. 8, 2015, pp. 736-41.
Chang JY, Wang YP, Wu YC, et al. Hematinic deficiencies and pernicious anemia in oral mucosal disease patients with macrocytosis. J Formos Med Assoc. 2015;114(8):736-41.
Chang, J. Y., Wang, Y. P., Wu, Y. C., Cheng, S. J., Chen, H. M., & Sun, A. (2015). Hematinic deficiencies and pernicious anemia in oral mucosal disease patients with macrocytosis. Journal of the Formosan Medical Association = Taiwan Yi Zhi, 114(8), 736-41. https://doi.org/10.1016/j.jfma.2015.03.015
Chang JY, et al. Hematinic Deficiencies and Pernicious Anemia in Oral Mucosal Disease Patients With Macrocytosis. J Formos Med Assoc. 2015;114(8):736-41. PubMed PMID: 25935499.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hematinic deficiencies and pernicious anemia in oral mucosal disease patients with macrocytosis. AU - Chang,Julia Yu-Fong, AU - Wang,Yi-Ping, AU - Wu,Yang-Che, AU - Cheng,Shih-Jung, AU - Chen,Hsin-Ming, AU - Sun,Andy, Y1 - 2015/04/29/ PY - 2014/11/25/received PY - 2015/02/07/revised PY - 2015/03/17/accepted PY - 2015/5/4/entrez PY - 2015/5/4/pubmed PY - 2016/11/10/medline KW - gastric parietal cell antibody KW - hemoglobin KW - macrocytosis KW - mean corpuscular volume KW - pernicious anemia KW - vitamin B12 SP - 736 EP - 41 JF - Journal of the Formosan Medical Association = Taiwan yi zhi JO - J Formos Med Assoc VL - 114 IS - 8 N2 - BACKGROUND/PURPOSE: Macrocytosis is defined as having the mean corpuscular volume (MCV) ≥ 100 fL. This study assessed hematinic deficiencies and pernicious anemia (PA) in oral mucosal disease patients with macrocytosis. METHODS: The blood hemoglobin (Hb), iron, vitamin B12, folic acid, and homocysteine concentrations and MCV in 60 oral mucosal disease patients with macrocytosis were measured and compared with the corresponding data in 120 age- and sex-matched healthy control participants. PA was defined by the World Health Organization (WHO) as having an Hb concentration < 13 g/dL for men and < 12 g/dL for women, an MCV ≥ 100 fL, a serum vitamin B12 level < 200 pg/mL, and serum gastric parietal cell antibody (GPCA) positivity. RESULTS: We found that 30 (50.0%), 7 (11.7%), 24 (40.0%), and three (5.0%) oral mucosal disease patients with macrocytosis had deficiencies of Hb (men < 13 g/dL, women < 12 g/dL), iron (< 60 μg/dL), vitamin B12 (< 200 pg/mL), and folic acid (< 4 mg/mL), respectively. Moreover, 38 (63.3%) and 16 (26.7%) macrocytosis patients had abnormally high blood homocysteine level (> 12.3 μM) and serum GPCA positivity, respectively. Macrocytosis patients had a significantly higher frequency of Hb, iron, or vitamin B12 deficiency, of abnormally elevated blood homocysteine level, and of GPCA positivity than healthy control participants (p < 0.001). However, only 16.7% of 60 macrocytosis patients were diagnosed as having PA by the WHO definition. CONCLUSION: Only 16.7% of oral mucosal disease patients with macrocytosis are discovered to have PA by the WHO definition. SN - 0929-6646 UR - https://www.unboundmedicine.com/medline/citation/25935499/Hematinic_deficiencies_and_pernicious_anemia_in_oral_mucosal_disease_patients_with_macrocytosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0929-6646(15)00143-6 DB - PRIME DP - Unbound Medicine ER -