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Chronotherapeutic drug delivery of Tamarind gum, Chitosan and Okra gum controlled release colon targeted directly compressed Propranolol HCl matrix tablets and in-vitro evaluation.
Int J Biol Macromol. 2015 Aug; 79:290-9.IJ

Abstract

The main objective of this investigation is to develop a chronotherapeutic drug delivery of various natural polymers based colon targeted drug delivery systems to treat early morning sign in BP. The polymers such as Tamarind gum, Okra gum and Chitosan were used in the formulation design. A model drug Propranolol HCl was incorporated in the formulation in order to assess the controlled release and time dependent release potential of various natural polymers. A novel polymer Tamarind gum was extracted and used as a prime polymer in this study to prove the superiority of this polymer over other leading natural polymer. Propranolol HCl was used as a model drug which undergoes hepatic metabolism and witnesses the poor bioavailability. The matrix tablets of Propranolol HCl were prepared by direct compression. The tablets were evaluated for various quality control parameters and found to be within the limits. Carbopol 940 was used as an auxiliary polymer to modify the drug release and physicochemical characteristics of the tablets. The in vitro release studies were performed in 0.1N HCl for 1.5h, followed by pH 6.8 phosphate buffer for 2h and pH 7.4 phosphate buffer till maximum amount of drug release. The in vitro release profile of the formulations were fitted with various pharmacokinetic mathematical models and analyzed for release profile. The formulations prepared with Tamarind gum prolonged the release for an extended period of time compared to other polymer based formulation and showed an excellent compression characteristic.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Newton AM
Rayat Bahra Institute of Pharmacy, Rayat Bahra University, Punjab, India; Research and Development Department, Jawaharlal Nehru Technological University, Hyderabad, India. Electronic address: dramjnewton@gmail.com.
Indana VL
Nirmala College of Pharmacy, Andhra Pradesh, India.
Kumar J
Rayat Bahra Institute of Pharmacy, Rayat Bahra University, Punjab, India.

MeSH

AbelmoschusAcrylic ResinsAnimalsChitosanColonDelayed-Action PreparationsDrug ChronotherapyDrug CompoundingDrug LiberationKineticsPlant GumsPropranololRatsTabletsTamarindus

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25936283

Citation

Newton, A M J., et al. "Chronotherapeutic Drug Delivery of Tamarind Gum, Chitosan and Okra Gum Controlled Release Colon Targeted Directly Compressed Propranolol HCl Matrix Tablets and In-vitro Evaluation." International Journal of Biological Macromolecules, vol. 79, 2015, pp. 290-9.
Newton AM, Indana VL, Kumar J. Chronotherapeutic drug delivery of Tamarind gum, Chitosan and Okra gum controlled release colon targeted directly compressed Propranolol HCl matrix tablets and in-vitro evaluation. Int J Biol Macromol. 2015;79:290-9.
Newton, A. M., Indana, V. L., & Kumar, J. (2015). Chronotherapeutic drug delivery of Tamarind gum, Chitosan and Okra gum controlled release colon targeted directly compressed Propranolol HCl matrix tablets and in-vitro evaluation. International Journal of Biological Macromolecules, 79, 290-9. https://doi.org/10.1016/j.ijbiomac.2015.03.031
Newton AM, Indana VL, Kumar J. Chronotherapeutic Drug Delivery of Tamarind Gum, Chitosan and Okra Gum Controlled Release Colon Targeted Directly Compressed Propranolol HCl Matrix Tablets and In-vitro Evaluation. Int J Biol Macromol. 2015;79:290-9. PubMed PMID: 25936283.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chronotherapeutic drug delivery of Tamarind gum, Chitosan and Okra gum controlled release colon targeted directly compressed Propranolol HCl matrix tablets and in-vitro evaluation. AU - Newton,A M J, AU - Indana,V L, AU - Kumar,Jatinder, Y1 - 2015/05/01/ PY - 2014/09/19/received PY - 2015/03/10/revised PY - 2015/03/24/accepted PY - 2015/5/5/entrez PY - 2015/5/6/pubmed PY - 2016/4/23/medline KW - Chitosan and Propranolol HCl KW - Colonic delivery KW - Okra gum KW - Tamarind gum SP - 290 EP - 9 JF - International journal of biological macromolecules JO - Int J Biol Macromol VL - 79 N2 - The main objective of this investigation is to develop a chronotherapeutic drug delivery of various natural polymers based colon targeted drug delivery systems to treat early morning sign in BP. The polymers such as Tamarind gum, Okra gum and Chitosan were used in the formulation design. A model drug Propranolol HCl was incorporated in the formulation in order to assess the controlled release and time dependent release potential of various natural polymers. A novel polymer Tamarind gum was extracted and used as a prime polymer in this study to prove the superiority of this polymer over other leading natural polymer. Propranolol HCl was used as a model drug which undergoes hepatic metabolism and witnesses the poor bioavailability. The matrix tablets of Propranolol HCl were prepared by direct compression. The tablets were evaluated for various quality control parameters and found to be within the limits. Carbopol 940 was used as an auxiliary polymer to modify the drug release and physicochemical characteristics of the tablets. The in vitro release studies were performed in 0.1N HCl for 1.5h, followed by pH 6.8 phosphate buffer for 2h and pH 7.4 phosphate buffer till maximum amount of drug release. The in vitro release profile of the formulations were fitted with various pharmacokinetic mathematical models and analyzed for release profile. The formulations prepared with Tamarind gum prolonged the release for an extended period of time compared to other polymer based formulation and showed an excellent compression characteristic. SN - 1879-0003 UR - https://www.unboundmedicine.com/medline/citation/25936283/Chronotherapeutic_drug_delivery_of_Tamarind_gum_Chitosan_and_Okra_gum_controlled_release_colon_targeted_directly_compressed_Propranolol_HCl_matrix_tablets_and_in_vitro_evaluation_ DB - PRIME DP - Unbound Medicine ER -